Director Phil Coulson/Sarge

Clark Gregg

Agent Melinda May

Ming-Na Wen

Daisy Johnson

Chloe Bennet

Leo Fitz

Iain De Caestecker

Agent Jemma Simmons

Elizabeth Henstridge

Alphonso "Mack" Mackenzie

Henry Simmons

Elena 'Yo-Yo' Rodriguez / Slingshot

Natalia Cordova-Buckley

Deke Shaw

Jeff Ward

Grant Ward / Hive

Brett Dalton

Guest Star

Joel Stoffer

Guest Star

Jolene Anderson

Guest Star

Tamara Taylor

Guest Star

Thomas E. Sullivan

Guest Star

Dichen Lachman

Guest Star

Austin Basis

Guest Star

Darren Barnet

Guest Star

Julian Acosta

Guest Star

Larry Clarke

Guest Star

Ryan Donowho

Guest Star

Tobias Jelinek

Guest Star

Joe Reegan

Lance Hunter

Nick Blood

Guest Star

Dianne Doan

Guest Star

Michael Gaston

Guest Star

Nora Zehetner

Guest Star

James Paxton

Bobbi Morse

Adrianne Palicki

Guest Star

Neal Bledsoe

Guest Star

Briana Venskus

Guest Star

Paulina Bugembe

Guest Star

Patton Oswalt

Guest Star

Stephen Bishop

Guest Star

Greg Finley

Lincoln Campbell

Luke Mitchell

Guest Star

Cameron Palatas

Guest Star

Maximilian Osinski

Guest Star

Tipper Newton

Guest Star

Dawan Owens

Holden Radcliffe

John Hannah

Guest Star

Bill Cobbs

Guest Star

Luke Baines

Guest Star

Sedale Threatt Jr.

Guest Star

Enver Gjokaj

Guest Star

Coy Stewart

Guest Star

Byron Mann

Guest Star

Patrick Warburton

Glenn Talbot / Gravitron

Adrian Pasdar

Robbie Reyes / Ghost Rider

Gabriel Luna

Guest Star

Shakira Barrera

Antoine Triplett

B.J. Britt

Aida / Agnes Kitworth / Madame Hydra

Mallory Jansen

Ron Glass

Raina

Ruth Negga

Jeffrey Mace / The Patriot

Jason O'Mara

Agent Burrows

Patrick Cavanaugh

Cal / The Doctor / Skye's Father

Kyle MacLachlan

Giyera

Mark Dacascos

Sunil Bakshi

Simon Kassianides

General Hale

Catherine Dent

Mike Peterson / Deathlok

J. August Richards

Stern Woman

Mary Eileen O'Donnell

Andrew Garner

Blair Underwood

Gideon Malick

Powers Boothe

Anton Ivanov

Zach McGowan

Daniel Whitehall

Reed Diamond

Gordon

Jamie Harris

Carl Creel

Brian Patrick Wade

Agent Weaver

Christine Adams

Ava

Tunisha Hubbard

Werner von Strucker

Spencer Treat Clark

Kasius

Dominic Rains

Sinara

Florence Faivre

Ian Quinn

David Conrad

Polly Hinton

Lola Glaudini

Waiter

Amos Glick

Bandleader

Martin Blasick

Izel

Karolina Wydra

Abel

Ryan Gray

Kara Palamas / Agent 33

Maya Stojan

Rosalind Price

Constance Zimmer

Snowflake

Brooke Williams

JT James / Hellfire

Axle Whitehead

Ruby Hale

Dove Cameron

John Garrett

Bill Paxton

Luther Banks

Andrew Howard

Agent Anderson

Alexander Wraith

Agent O'Brien

Derek Phillips

Qovas

Peter Mensah

Robin Hinton

Lexy Kolker

Alisha Whitley / Alisha

Alicia Vela-Bailey

Malachi

Christopher James Baker

Jaco

Winston James Francis

Lash

Matthew Willig

Joey Gutierrez

Juan Pablo Raba

Carla Talbot

Raquel Gardner

Agent Diaz / Quinjet Pilot

Geri-Nikole Love

Agent Prince

Ricardo Walker

Robert Gonzales

Edward James Olmos

Agent Oliver

Mark Allan Stewart

Kebo

Daz Crawford