Ned

Lee Pace

Charlotte"Chuck" Charles

Anna Friel

Emerson Cod

Chi McBride

Vivian Charles

Ellen Greene

Lily Charles

Swoosie Kurtz

Olive Snook

Kristin Chenoweth

Young Ned

Field Cate

Narrator (voice)

Jim Dale

Guest Star

Shelley Berman

Guest Star

Fred Willard

Kentucky Fitz

Autumn Reeser

Guest Star

Debra Mooney

Guest Star

Missi Pyle

Guest Star

Eric Stonestreet

Guest Star

Danny Comden

Guest Star

Nicole Greenwood

Simone Hundin

Christine Adams

Guest Star

Samantha Bailey

Guest Star

Mackenzie Smith

Guest Star

David Arquette

Guest Star

Alex Miller

Guest Star

Patrick Fischler

Guest Star

Rachael Harris

Young Chuck

Sammi Hanratty

Guest Star

Hayes MacArthur

Guest Star

Ellery Sprayberry

Guest Star

Steven Walsh Jr.

Guest Star

Kristen Olson

Guest Star

Avery Stevens

Guest Star

Sy Richardson

Woolsey Nicholls

French Stewart

Guest Star

Orlando Jones

Guest Star

Jennifer Elise Cox

Mother Superior

Diana Scarwid

Guest Star

Casey Weiant

Guest Star

Michael Weaver

Guest Star

Dana Davis

Guest Star

Mary Kay Place

Guest Star

Graham Miller

Guest Star

Giselle Gail Gaines

Dwight Dixon

Stephen Root

Guest Star

Richard Benjamin

Guest Star

Michael Hitchcock

Guest Star

Ivana Milicevic

Guest Star

Leyna Nguyen

Guest Star

Beth Grant

Guest Star

Ethan Phillips

Guest Star

Paul F. Tompkins

Guest Star

Francesca P. Roberts

Guest Star

George Segal

Guest Star

Michael C. Alexander

Guest Star

Mae Hi

Guest Star

Peter Cambor

Guest Star

Mary K. Devault

Guest Star

Josh Hopkins

Guest Star

Nora Dunn

Guest Star

Tim Bagley

Guest Star

David Koechner

Guest Star

Mo Collins

Guest Star

Ping Wu

Guest Star

Fred Williamson

Guest Star

Wayne Wilderson

Guest Star

Joshua LeBar

Guest Star

Jamison Yang

Guest Star

Theodore Zoumpoulidis

Guest Star

Gina Torres

Guest Star

Willie Garson

Guest Star

Graham McTavish

Guest Star

Alexandra Barreto

Guest Star

Alexander Gould

Guest Star

Andrea Lui

Eugene Mulchandani

Nicholas Khayyat

Ned's Mother

Tina Gloss

Guest Star

Wendie Malick

Guest Star

Lee Arenberg

Guest Star

Robert Picardo

Guest Star

Phil Abrams

Guest Star

Sam Pancake

Guest Star

Jackie Harris

Guest Star

Perry Anzilotti

Ingmar Todd

Daeg Faerch

Guest Star

Connor Merkovich

Guest Star

Robin Gwynne

Guest Star

Blake Kushi

Guest Star

Joey Slotnick

Guest Star

Ethan Kogan

Guest Star

Amelia Borella

Guest Star

Josh Randall

Guest Star

Ron Yuan

Guest Star

Joleen Lutz

Guest Star

Mark Povinelli

Guest Star

Constance Zimmer

Guest Star

Keenan Merkovich

Ned's Father

Jon Eric Price

Guest Star

Michael James McDonald

Guest Star

Matt Winston

Guest Star

Googy Gress

Guest Star

Craig Tsuyumine

Guest Star

Rachel Cannon

Guest Star

Allen C. Liu