Riley/Huey

Regina King

Grandad

John Witherspoon

Grandad

J.D. Witherspoon

Tom Dubois (voice)

Cedric Yarbrough

Jazmine

Gabby Soleil

Sarah Dubois (voice)

Jill Talley

Uncle Ruckus

Gary Anthony Williams

Ed Wuncler (voice)

Ed Asner

A Pimp Named Slickback (voice)

Katt Williams

Werner Herzog

Himself

Bill Maher

Siri (voice) / Kim Kardashian (voice) / Loyal White Woman (voice)

Grey DeLisle

Wedgie Rudlin (voice)

Donald Faison

Geraldine (voice) / Boss Willona (voice)

Jenifer Lewis

Customer (voice)

Kym Whitley

Rummy (voice)

Samuel L. Jackson

Chico / Pat O'Brien (voice)

Barry Sobel

Pretty Boy Flizzy (voice)

Michael B. Jordan

Cristal (voice)

Tiffany Thomas

Jigme (voice)

Dante Basco

Ebony Brown

Gina Torres

Sturdy Harris (voice)

Dennis Haysbert

Janet (voice)

Candi Milo