Master Chief Petty Officer John-117

Pablo Schreiber

Dr. Catherine Halsey

Natascha McElhone

Admiral Margaret Parangosky

Shabana Azmi

Spartan Riz-028

Natasha Culzac

Soren-066

Bokeem Woodbine

Dr. Miranda Keyes

Olive Gray

Kwan Ha

Yerin Ha

Spartan Vannak-134

Bentley Kalu

Cortana (voice)

Jen Taylor

Spartan Kai-125

Kate Kennedy

Makee

Charlie Murphy

Dr. Adun Saly

Ryan McParland

Captain Jacob Keyes

Danny Sapani

Laera

Fiona O'Shaughnessy

Vinsher Grath

Burn Gorman

James Ackerson

Joseph Morgan

Corporal Talia Perez

Cristina Rodlo

Kessler

Tylan Bailey

Cortana

Christina Bennington

Arbiter Var 'Gatanai

Viktor Åkerblom

Young John

Casper Knopf

Hierarch Mercy (voice)

Julian Bleach

The Mother

Olwen Fouéré

Kaidon

Jamie Beamish

John's Mother

Sarah Ridgeway

Ops Tech / Ops Tech Pereira / Sangheili Guard

Hans Peterson

John's Father

Duncan Pow

Hierarch Regret (voice)

Hilton McRae

MP Malya

Claudius Peters

Hierarch Truth (voice)

Karl Johnson

Carina

Juliette Motamed

Castor

David Crowley

Virgil

Iliasz Shweirif

Antares

Ivanno Jeremiah

Manuela Perez

Maria Luisa Costa

Louis-036

Marvin Jones III

Danilo

Christian Ochoa Lavernia

Captain Briggs

Anna Koval

Lt Mullins

Dani Klupsch

Tech Smith

Ailsa Davidson

Tech Jones

Tom Gaskin