Sheldon Cooper

Iain Armitage

Mary Cooper

Zoe Perry

George Cooper Sr.

Lance Barber

Georgie Cooper

Montana Jordan

Missy Cooper

Raegan Revord

Pastor Jeff Hodgkins

Matt Hobby

Connie Tucker

Annie Potts

Sheldon Cooper (voice)

Jim Parsons

Dr. John Sturgis

Wallace Shawn

Brenda Sparks

Melissa Peterman

Jana Boggs

Ava Allan

Dale Ballard

Craig T. Nelson

Billy Sparks

Wyatt McClure

Dr. Kwok

Tom Yi

Mandy McAllister

Emily Osment

Wayne Wilkins

Doc Farrow

Grant Linkletter

Ed Begley Jr.

Tam Nguyen

Ryan Phuong

Tom Petersen

Rex Linn

Hubert Givens

Brian Stepanek

Linda Hagemeyer

Wendie Malick

Peg

Nancy Linehan Charles

Evelyn Ingram

Danielle Pinnock

Victoria MacElroy

Valerie Mahaffey

Sheryl Hutchins

Sarah Baker

Audrey McAllister

Rachel Bay Jones

Jim McAllister

Will Sasso

Paige Swanson

Mckenna Grace

Veronica Duncan

Isabel May

Wade

Grady Lee Richmond

Rob

Dan Byrd

Kimberly / Local Newscaster

Katherine Von Till

June

Reba McEntire

Linda Swanson

Andrea Anders

Robin

Mary Grill

Gene Lundy

Jason Alexander

Herschel Sparks

Billy Gardell

Derek

Nick Alvarez