Angus "Mac" MacGyver

Lucas Till

Jack Dalton

George Eads

Riley Davis

Tristin Mays

Patricia Thornton

Sandrine Holt

Matty Webber

Meredith Eaton

Wilt Bozer

Justin Hires

Nikki Carpenter

Tracy Spiridakos

Desiree "Desi" Nguyen

Levy Tran

John Kendrick

Vinnie Jones

Russ Taylor

Henry Ian Cusick

Vincent the Director

Cory Scott Allen

Tiffany

India Batson

Jill Morgan

Kate Bond

Doorman

Alessandro Folchitto

Samantha Cage

Isabel Lucas

Lead Tech/Dying

Elizabeth Tavares

Oversight

Tate Donovan

Murdoc

David Dastmalchian

Pilot

Kenneth Israel

Co-Pilot

Michael E. Sanders

Robot (voice)

Nicholas Guest

Elwood

William Baldwin

Lead Tech DXS

Craig Newman

Billy Colton

Lance Gross

Armed Guard

Don DiPetta

Scarlett

Amber Skye Noyes

Charlie Robinson

Emerson Brooks

Parker

Alexandra Grey

Nasha

Sibongile Mlambo

Sergei / Russian Guard #2 / Silver Wall Security Guard

Andre Pushkin

MacGyver

Richard Dean Anderson

Andy Colson

Dana Elcar

Dr. Burke

Michael C. Gwynne

Gen. Relkwin

Michael Fairman

Reggie

Shavar Ross

Barbara Spencer

Darlanne Fluegel

Dr. Sidney Marlowe

Olaf Pooley

Major Dennis

Charles Lanyer

Technician #1

Charles Bouvier

Technician #3

Larry Watson

Pilot

Richard Partlow