Self - Host

John Mulaney

Self - Announcer

Richard Kind

Self - Actor and Filmmaker

Michael Keaton

Self (Pre-Tape Segment) / Doctor (Pre-Tape Segment) / Self

Jeremy Levick

Self - Musician and Activist

Joan Baez

Self / Self - Musical Guest

Fred Armisen

Butterball (Pre-Tape Segment) / Self (Pre-Tape Segment) / Self

Alex Scordelis

Self (Pre-Tape Segment) / Patient (Pre-Tape Segment)

Rajat Suresh

Additional Cast / Geirsten / Self (Pre-Tape Segment)

Fran Gillespie

Self - Production Assistant / Fan (Pre-Tape Segment)

Kevin Brew

Mohel Abraham Davis - Amateur Urologist / Self (Pre-Tape Segment) / Bubbles Jackson

Langston Kerman

Additional Cast / Self (Pre-Tape Segment)

Vanessa Ramos

Self (Pre-Tape Segment) / Shannon

Anna Drezen

Business Man #1 / Stunt Double (Pre-Tape Segment)

Paul Lacovara

Young Woman #1 (Pre-Tape Segment) / Additional Cast

Kassiani Mamalakis

Mugshot Man (Pre-Tape Segment) / Self - Cue Cards

Larry Blum

Hector the Teen Driver / Self / Self - Actor and Best-Selling Author

Henry Winkler

Self - Comedian

Conan O'Brien

Hyacinth (Pre-Tape Segment)

Bee-Be Smith

Self (Pre-Tape Segment)

David Ferguson

Self (Pre-Tape Segment) / Mayor Mandal (Pre-Tape Segment)

Mandal

Self - Personal Finance Columnist

Jessica Roy

Self - Musical Guest

Eric Bobo

Self - Musical Guest

B-Real

Self - Musical Guest

Sen Dog

Self (Pre-Tape Segment)

Reese Webster

Old Woman #1 (Pre-Tape Segment)

Michelle Falerne

Young Man #1 (Pre-Tape Segment)

Kyle Kittredge

Young Man #2 (Pre-Tape Segment)

Lucas Cuca

Young Man #4 (Pre-Tape Segment)

Brendan Sweeney

Young Man #3 (Pre-Tape Segment)

Ryan Hayes

Business Man #2 (Pre-Tape Segment)

James Pryor

Business Man #3 (Pre-Tape Segment)

Mark Nehls

Business Man #4 (Pre-Tape Segment)

Marcos Leiva

Self - Actor and Director

Ben Stiller

Self - Actor and Comedian

Nick Kroll

Self - Cruise Industry Expert

Anne Kalosh

Self - Musical Guest

Kim Gordon

Self - Musical Guest

Kim Deal

Self - No Limit Soldiers - Active Duty

Silkk The Shocker

Jerica (Pre-Tape Segment)

Vanessa Bayer

Self - Actor and Comedian

Pete Davidson

Self - Comedian

Luenell

Self - Licensed Funeral Director and Embalmer

Raymundo Perez-Plascencia

Self - Musical Guest

Marisa "Missy" Dabice

Self - Musical Guest

Kaleen Reading

Self - Musical Guest

Colins Regisford

Self - Musical Guest

Maxine Steen

Self - Actor (Pre-Tape Segment)

Joe Manganiello

Self - News Anchor (Pre-Tape Segment)

Willie Geist

Additional Cast

Katherine Koenig

Self - Comedian

Wanda Sykes

Self - Writer and Film Director

John Waters

Self - Comedian and Actor

Stavros Halkias

Self - Supreme Court Lawyer

Neal Katyal

Self - Musical Guest

Daniel Hope

Self - Musical Guest

New Century Chamber Orchestra

Self - Actor (Pre-Tape Segment)

Randall Park

Self - Camera OP 2

Tom DeBone

Self - Director of Photography (Pre-Tape Segment)

Pokai Liao

Jelly Roll

Aidy Bryant

Fan (Pre-Tape Segment)

Jack Brownlee

Woman (Pre-Tape Segment)

Januchi Egbuho

Fan (Pre-Tape Segment)

Kyle Martinez-McIntosh

Driver (Pre-Tape Segment)

Miles Motley

Heights Kid (Pre-Tape Segment)

Miras Mukhit

Heights Kid (Pre-Tape Segment)

Michael Royal

Security Guard (Pre-Tape Segment)

Gene Pleasant Russell

Fan (Pre-Tape Segment)

Stephanie Schille

Saymo Handler (Pre-Tape Segment)

Margarita Shestitko

Saymo Handler (Pre-Tape Segment)

Ryan Thompson

Heights Kid (Pre-Tape Segment)

Alayah Williams

Self - Actor and Comedian

Bill Hader

Self - Actress and Comedian

Chelsea Peretti

Self - Stunt Performer and Actor

Johnny Knoxville

Self - Human Resources Executive and Employee Coach

Catie Maillard

Self - Musical Guest

Bartees Strange

Self - Musical Guest

Randy Newman

Self - Actress and Comedian

Ayo Edebiri

Self - Musical Guest

Alex Edkins

Self - Musical Guest

Hayden Menzies

Self - Musical Guest

Chris Slorach

Chesterton Romero Cheadle

André De Shields

Self (Pre-Tape Segment)

Jimmy Au

Dancer

Taylor Banks

Dancer

Precious Gilbert

Dancer

Khadijah Wilson

Dancer

Nina Gumbs

Nurse (Pre-Tape Segment)

Jillian Morgese

Dumpster Thing

Bonnie Aarons

Self

Charlie Wilson

Additional Cast

Sergio Hernandez

Additional Cast

Sandra Mendelson Brown

Additional Cast

Adam Schatz

Additional Cast

Kate Lyn Sheil

Heights Men - 5'0

Fernando Molina

Heights Men - 5'1

Noah Vu

Heights Men - 5'2

Larry Gee

Heights Men - 5'3

Noah Andrade

Heights Men - 5'4

Jose Cordova