Mahershala Ali

Mark Grayson / Invincible (voice)

Steven Yeun

Nolan Grayson / Omni-Man (voice)

J.K. Simmons

General Kregg (voice) / Damien Darkblood (voice) / General Kregg

Clancy Brown

Debbie Grayson

Sandra Oh

Nicole Byer

Allen the Alien

Seth Rogen

Jeffrey Donovan

Shrinking Rae / Monster Girl / GDA Tech (voice)

Grey DeLisle

Art Rosebaum

Mark Hamill

Cecil Stedman

Walton Goggins

Jon Hamm

Eve (voice) / Eve / College Girl (voice)

Gillian Jacobs

Rex (voice) / Rex / Zombie #2 (voice)

Jason Mantzoukas

Djimon Hounsou

Ezra Miller

Fightmaster & Dropkick

Mae Whitman

Donald (voice) / Donald / Doc Seismic (voice)

Chris Diamantopoulos

Amber Bennett

Zazie Beetz

Oliver Grayson

Max Burkholder

Black Samson (voice) / Black Samson / Kyle (voice)

Khary Payton

Battle Beast

Michael Dorn

Immortal / Rudy (voice) / Rudy

Ross Marquand

William (voice) / William / GDA Agents (voice)

Andrew Rannells

Robot (voice) / Robot / Robot Life Pod (voice)

Zachary Quinto

Kate Cha/Dupli-Kate

Malese Jow

Additional Voices (voice) / Fishmonger

Robert Kesselman

Additional Voices (voice) / Hazmat Responder

Dan Navarro

Additional Voices (voice) / Guard

Ami Shukla

Additional Voices (voice) / GDA Agent #2 / Bridget

Nyima Funk

Mauler Twins/Monster Girl

Kevin Michael Richardson

Bulletproof (voice) / Data Twin #1 / Cute Guy

Jay Pharoah

Killcannon / Adam / The Mad Scientist (voice)

Fred Tatasciore

Angstrom Levy (voice) / Angstrom Levy / Angstrom #646 (voice)

Sterling K. Brown

Shapesmith (voice) / Shapesmith / Rus Livingston

Ben Schwartz

Paul (voice)

Cliff Curtis

Oliver (voice)

Christian Convery

Rick (voice)

Luke Macfarlane

News Anchor (voice) / Newscaster / Umpire

Gary Anthony Williams

Darkwing (voice) / Darkwing / Husband

Cleveland Berto

April (voice)

Calista Flockhart

Mrs. Farnsley / Caitlin / Denise (voice)

Kari Wahlgren

DA Sinclair (voice) / Viltrumite / Alien Guard

Eric Bauza

King Lizard (voice)

Scoot McNairy

Principal / Dean Winslow (voice) / Principal Winslow

Reginald VelJohnson

Multi-Paul (voice)

Simu Liu