Mark Grayson / Invincible (voice)

Steven Yeun

Debbie Grayson (voice)

Sandra Oh

Nolan Grayson / Omni-Man (voice)

J.K. Simmons

Amber Bennett (voice)

Zazie Beetz

Cecil Stedman (voice)

Walton Goggins

Shrinking Rae / Amanda / Monster Girl

Grey DeLisle

William Clockwell (voice) / Everest Climber (voice)

Andrew Rannells

Samantha Eve Wilkins / Atom Eve (voice) / Atom Eve

Gillian Jacobs

Donald Ferguson (voice) / Donald Ferguson / Doc Seismic (voice)

Chris Diamantopoulos

Rex Sloan / Rex Splode (voice)

Jason Mantzoukas

Mauler Twins (voice) / Mauler Twins / Monster Girl's Monster Form (voice)

Kevin Michael Richardson

Black Samson (voice) / Black Samson / Astronaut (voice)

Khary Payton

Robot (voice) / Robot / Robot Life Pod (voice)

Zachary Quinto

Kate Cha / Dupli-Kate (voice) / Dupli-Kate

Melise

Eve's Father / Biology Professor (voice) / Killcannon

Fred Tatasciore

The Immortal / Rudy Conners (voice) / Aquarus

Ross Marquand

Additional Voices (voice)

Robert Kesselman

Additional Voices (voice)

Dan Navarro

Additional Voices (voice)

Ami Shukla

Additional Voices (voice) / Bridget

Nyima Funk

Allen the Alien (voice)

Seth Rogen

Damien Darkblood (voice) / Damien Darkblood / Bryant (voice)

Clancy Brown

Art Rosenbaum (voice)

Mark Hamill

Bulletproof (voice) / Bulletproof / Komodo Dragon

Jay Pharoah

Reporter (voice) / Space Director / TV Announcer

Gary Anthony Williams

Shapesmith / Rus / Corey (voice)

Ben Schwartz

Director

Vinton Heuck

Director

Robert Valley

Director

Sol Choi