Mark Grayson / Invincible (voice)
Steven Yeun
Debbie Grayson (voice)
Sandra Oh
Nolan Grayson / Omni-Man (voice)
J.K. Simmons
Amber Bennett (voice)
Zazie Beetz
Cecil Stedman (voice)
Walton Goggins
Shrinking Rae / Amanda / Monster Girl
Grey DeLisle
William Clockwell (voice) / Everest Climber (voice)
Andrew Rannells
Samantha Eve Wilkins / Atom Eve (voice) / Atom Eve
Gillian Jacobs
Donald Ferguson (voice) / Donald Ferguson / Doc Seismic (voice)
Chris Diamantopoulos
Rex Sloan / Rex Splode (voice)
Jason Mantzoukas
Mauler Twins (voice) / Mauler Twins / Monster Girl's Monster Form (voice)
Kevin Michael Richardson
Black Samson (voice) / Black Samson / Astronaut (voice)
Khary Payton
Robot (voice) / Robot / Robot Life Pod (voice)
Zachary Quinto
Kate Cha / Dupli-Kate (voice) / Dupli-Kate
Melise
Eve's Father / Biology Professor (voice) / Killcannon
Fred Tatasciore
The Immortal / Rudy Conners (voice) / Aquarus
Ross Marquand
Additional Voices (voice)
Robert Kesselman
Additional Voices (voice)
Dan Navarro
Additional Voices (voice)
Ami Shukla
Additional Voices (voice) / Bridget
Nyima Funk
Allen the Alien (voice)
Seth Rogen
Damien Darkblood (voice) / Damien Darkblood / Bryant (voice)
Clancy Brown
Art Rosenbaum (voice)
Mark Hamill
Bulletproof (voice) / Bulletproof / Komodo Dragon
Jay Pharoah
Reporter (voice) / Space Director / TV Announcer
Gary Anthony Williams
Shapesmith / Rus / Corey (voice)
Ben Schwartz