Niles

Daniel Davis

Fran Fine

Fran Drescher

Maxwell Sheffield

Charles Shaughnessy

Chastity Claire `C.C.' Babcock

Lauren Lane

Sylvia Fine

Renee Taylor

Maggie Sheffield

Nicholle Tom

Val Toriello

Rachel Chagall

Brighton Sheffield

Benjamin Salisbury

Grace Sheffield

Madeline Zima

Guest Star

Chevy Chase

Guest Star

Robert Vaughn

Yetta Rosenberg

Ann Morgan Guilbert

Guest Star

Ajay Mehta

Guest Star

Maria Conchita Alonso

Guest Star

Howard Preiser

Guest Star

Dick Martin

Guest Star

Rahi Azizi

Guest Star

Frank Lombardi

Guest Star

Lainie Kazan

Guest Star

Ray Romano

Guest Star

Brian Setzer

Guest Star

Harry Van Gorkum

Guest Star

Joan Van Ark

Guest Star

Allan Rich

Guest Star

Elton John

Guest Star

Dr. Joyce Brothers

Guest Star

Benjamin Lum

Guest Star

Andrew C. Mackenzie

Guest Star

Sayed Badreya

Guest Star

Harry Hamlin

Guest Star

Jim Lau

Uncle Stanley / Morty Fine

Morty Drescher

Guest Star

Roseanne

Guest Star

Spalding Gray

Guest Star

Michael Bolton

Guest Star

Joey Slotnick

Guest Star

Coolio

Sara Sheffield

Bess Armstrong

Guest Star

Leila Kenzle

Guest Star

John Lennox

Guest Star

Michael Ensign

Dottie / Bridal Shop Clerk

DeeDee Rescher

Guest Star

Chris Hogan

Guest Star

Anna Berger

Guest Star

Lyle Kanouse

Guest Star

Sandy Hackett

The Chester

Chester Drescher

Guest Star

Leslie Rogers

Guest Star

Ray Charles

Guest Star

Whoopi Goldberg

Guest Star

Lisa Loeb

Guest Star

Cindy Adams

Guest Star

Jennie Kwan

Guest Star

David Furnish

Guest Star

Yvonne Sciò

Guest Star

Marla Maples

Guest Star

Scott Baio

Guest Star

T.K. Carter

Guest Star

Ben Thomas

Dr. Reynolds

Nora Dunn

Guest Star

Wendy Schenker

Guest Star

Kane Picoy

Guest Star

Jessica Tuck

Guest Star

Faryn Einhorn

Guest Star

Bryant Gumbel

Guest Star

Richard Harris

Guest Star

Richard Edson

Guest Star

Fred Stoller

Guest Star

Jennifer Edwards

Guest Star

Sparkle

Guest Star

Lance Reddick

Guest Star

Ismael Carlo

Guest Star

Kathryn Joosten

Guest Star

Casey Williams

Guest Star

Don Condon

Guest Star

Patrick Howard

Guest Star

Naomi Serotoff

Guest Star

Gregory Wheeler

Guest Star

Jovan Rameau

Guest Star

Dorothy Lyman

Guest Star

Vasili Bogazianos

Guest Star

Gunnar Peterson

Michael

Andrew Levitas

Guest Star

Rowena Balos

Guest Star

Jake McKinney

Orderly / Policeman

Lawrence Mandley

Aunt Rose

Sylvia Drescher

Uncle Jack

Zack Norman

Roger Clinton

Roger Clinton