Niles

Daniel Davis

Fran Fine Sheffield

Fran Drescher

Maxwell Sheffield

Charles Shaughnessy

Chastity Claire "C.C' Babcock

Lauren Lane

Margaret "Maggie" Sheffield

Nicholle Tom

Brighton Sheffield

Benjamin Salisbury

Sylvia Fine

Renee Taylor

Grace Sheffield

Madeline Zima

Guest Star

Tom Bergeron

Guest Star

Steve Lawrence

Val Toriello

Rachel Chagall

Guest Star

Lisa Stanley

Guest Star

Jonny Ryder

Guest Star

Whoopi Goldberg

Guest Star

Rita Rudner

Guest Star

Ray Stricklyn

Yetta Rosenberg

Ann Morgan Guilbert

Guest Star

Lainie Kazan

Guest Star

Chris Elliott

Guest Star

Donna Douglas

Dr. Reynolds

Nora Dunn

Guest Star

DeeDee Rescher

Guest Star

Anne Lambton

Chopper Pilot

Ray Abruzzo

Guest Star

Bruce Vilanch

Michael

Andrew Levitas

Guest Star

Bob Goen

Guest Star

Ryan McPartlin

Guest Star

Lynn Redgrave

Guest Star

Christopher Winfield

Guest Star

Ray Charles

Guest Star

Margaret Cho

Guest Star

Jason Andrews

Guest Star

George Coe

Guest Star

Martin Mull

Guest Star

Nancy Cassaro

Guest Star

James McDonnell

Guest Star

Burke Roberts

Guest Star

Casey Williams

Guest Star

Jeff Cain

Guest Star

Jared Doud

The Chester

Chester Drescher

Trick-or-Treater

Wilder Shaw

Guest Star

Tim Watters

Guest Star

Chad Everett

Guest Star

Sophie Ward

Guest Star

Maxwell Caulfield

Guest Star

Diane Baker

Guest Star

Hal Linden

Guest Star

Howie Mandel

Guest Star

Dakin Matthews

Guest Star

Athena Stensland

Guest Star

Susan Krebs

Guest Star

Jasmin Beto

Nurse

Roz Kern

Guest Star

Marji Martin

Guest Star

Tawny Meyer

Guest Star

John Muntner

Guest Star

Charlie Newmark

Trick-or-Treater

Alex Sternin

Guest Star

Chris Bruno

Guest Star

Jamie Renee Smith

Guest Star

Christopher Marquette

Guest Star

Jack Shearer

Guest Star

James Edson

Uncle Stanley / Morty Fine

Morty Drescher

Guest Star

Loren Michaels

Car Dealer

Steve Posner

Guest Star

Matthew Viera

Guest Star

Coolio

Guest Star

Preston Wamsley

Guest Star

Susan Goodman

Guest Star

Charles Kahlenberg

Guest Star

Tim Thompson

Guest Star

Dona Hardy

Orderly / Policeman

Lawrence Mandley

Aunt Rose

Sylvia Drescher

Guest Star

Fred Stoller

Uncle Jack

Zack Norman

Guest Star

Dennis Dun

Roger Clinton

Roger Clinton

Guest Star

Saemi Nakamura

Guest Star

Bob Gunter

Reporter

James Edson

Solo singer

Linda Harmon

Director

Dorothy Lyman

Director

Gail Mancuso

Director

Lee Shallat Chemel

Director

Steve Posner

Director

Fran Drescher

Director

Peter Marc Jacobson