Niles
Daniel Davis
Fran Fine Sheffield
Fran Drescher
Maxwell Sheffield
Charles Shaughnessy
Chastity Claire "C.C' Babcock
Lauren Lane
Margaret "Maggie" Sheffield
Nicholle Tom
Brighton Sheffield
Benjamin Salisbury
Sylvia Fine
Renee Taylor
Grace Sheffield
Madeline Zima
Guest Star
Tom Bergeron
Guest Star
Steve Lawrence
Val Toriello
Rachel Chagall
Guest Star
Lisa Stanley
Guest Star
Jonny Ryder
Guest Star
Whoopi Goldberg
Guest Star
Rita Rudner
Guest Star
Ray Stricklyn
Yetta Rosenberg
Ann Morgan Guilbert
Guest Star
Lainie Kazan
Guest Star
Chris Elliott
Guest Star
Donna Douglas
Dr. Reynolds
Nora Dunn
Guest Star
DeeDee Rescher
Guest Star
Anne Lambton
Chopper Pilot
Ray Abruzzo
Guest Star
Bruce Vilanch
Michael
Andrew Levitas
Guest Star
Bob Goen
Guest Star
Ryan McPartlin
Guest Star
Lynn Redgrave
Guest Star
Christopher Winfield
Guest Star
Ray Charles
Guest Star
Margaret Cho
Guest Star
Jason Andrews
Guest Star
George Coe
Guest Star
Martin Mull
Guest Star
Nancy Cassaro
Guest Star
James McDonnell
Guest Star
Burke Roberts
Guest Star
Casey Williams
Guest Star
Jeff Cain
Guest Star
Jared Doud
The Chester
Chester Drescher
Trick-or-Treater
Wilder Shaw
Guest Star
Tim Watters
Guest Star
Chad Everett
Guest Star
Sophie Ward
Guest Star
Maxwell Caulfield
Guest Star
Diane Baker
Guest Star
Hal Linden
Guest Star
Howie Mandel
Guest Star
Dakin Matthews
Guest Star
Athena Stensland
Guest Star
Susan Krebs
Guest Star
Jasmin Beto
Nurse
Roz Kern
Guest Star
Marji Martin
Guest Star
Tawny Meyer
Guest Star
John Muntner
Guest Star
Charlie Newmark
Trick-or-Treater
Alex Sternin
Guest Star
Chris Bruno
Guest Star
Jamie Renee Smith
Guest Star
Christopher Marquette
Guest Star
Jack Shearer
Guest Star
James Edson
Uncle Stanley / Morty Fine
Morty Drescher
Guest Star
Loren Michaels
Car Dealer
Steve Posner
Guest Star
Matthew Viera
Guest Star
Coolio
Guest Star
Preston Wamsley
Guest Star
Susan Goodman
Guest Star
Charles Kahlenberg
Guest Star
Tim Thompson
Guest Star
Dona Hardy
Orderly / Policeman
Lawrence Mandley
Aunt Rose
Sylvia Drescher
Guest Star
Fred Stoller
Uncle Jack
Zack Norman
Guest Star
Dennis Dun
Roger Clinton
Roger Clinton
Guest Star
Saemi Nakamura
Guest Star
Bob Gunter
Reporter
James Edson
Solo singer
Linda Harmon