William Masters

Michael Sheen

Virginia Johnson

Lizzy Caplan

Dr. Barton Scully

Beau Bridges

Libby Masters

Caitlin FitzGerald

Dr. Austin Langham

Teddy Sears

Ethan Haas

Nick D'Agosto

Betty DiMello

Annaleigh Ashford

Dr. Lillian DePaul

Julianne Nicholson

Guest Star

Josh Randall

Gene Moretti

Greg Grunberg

Lester Linden

Kevin Christy

Guest Star

Adam Arkin

Guest Star

Keke Palmer

Guest Star

Barry Watson

Barbara Sanderson

Betsy Brandt

Guest Star

Rene Auberjonois

Jane Martin

Heléne Yorke

Guest Star

Alex Wyse

Guest Star

Sarah Sido

Estabrooks Masters

Ann Dowd

Margaret Scully

Allison Janney

Guest Star

Johnny Sneed

Vivian Scully

Rose McIver

Robert Franklin

Jocko Sims

Guest Star

Marin Ireland

Tessa Johnson

Kayla Madison

Guest Star

Jonathan T. Floyd

Guest Star

Evan Arnold

George Johnson

Mather Zickel

Guest Star

Melanie Paxson

Guest Star

John Billingsley

Guest Star

Melinda Page Hamilton

Guest Star

Sterling K. Brown

Guest Star

Renée Elise Goldsberry

Guest Star

Nicole Steinwedell

Guest Star

Marc Evan Jackson

Guest Star

Artemis Pebdani

Guest Star

Alexa Alemanni

Guest Star

Scott Michael Campbell

Guest Star

Danny Huston

Guest Star

Brian Howe

Herb Spleeb

Jack Laufer

Guest Star

Jeremiah Birkett

Guest Star

Erin Cummings

Guest Star

Susie Schelling

Guest Star

Kevin Shinick

Johnny Masters

Jaeden Martell

Guest Star

Courtney B. Vance

Guest Star

Andy Milder

Helen Schiff

Sarah Silverman

Guest Star

Larry Joshua

Guest Star

Brandon Scott

Guest Star

George Mackey

Guest Star

Peri Gilpin

Henry Johnson

Cole Sand

Guest Star

Rya Kihlstedt

Guest Star

Ana Walczak

Dan Logan

Josh Charles

Guest Star

Jora Senane

Guest Star

Elizabeth Bogush

Guest Star

Yvans Jourdain

Guest Star

Lance Barber

Guest Star

Kerry O'Malley

Guest Star

Christian Borle

Tessa Johnson

Isabelle Fuhrman

Guest Star

Drew Rausch

Guest Star

Larry Poindexter

Guest Star

Jay Ellis

Guest Star

Bradley White

Guest Star

Jillian Reeves de Ortiz

Paul Edley

Benjamin Koldyke

Guest Star

Vivian Kerr

Guest Star

Cutter Garcia

Dr. Art Dreesen

Jeremy Strong

Guest Star

Jules Lambert

Dr. Nancy Leveau

Betty Gilpin

Guest Star

Nina Daniels

Bob Drag

Danny Jacobs

Bram Keller

David Walton

Guy

Nick Clifford

Harry Eshelman

Michael O'Keefe

Chancellor Fitzhugh

Garrett M. Brown

Ronald Sturgis

Colin Woodell

Louise Bell

Niecy Nash

Jenny Masters

Alyvia Alyn Lind