William Masters

Michael Sheen

Virginia Johnson

Lizzy Caplan

Dr. Barton Scully

Beau Bridges

Libby Masters

Caitlin FitzGerald

Dr. Austin Langham

Teddy Sears

Betty DiMello

Annaleigh Ashford

Guest Star

Judy Greer

Lester Linden

Kevin Christy

George Johnson

Mather Zickel

Harry Eshelman

Michael O'Keefe

Guest Star

Necar Zadegan

Guest Star

Tate Donovan

Guest Star

Maury Sterling

Guest Star

Eric Lange

Guest Star

Ben Koldyke

Guest Star

Laura Silverman

Guest Star

Waleed Zuaiter

Guest Star

Emily Kinney

Jane Martin

Heléne Yorke

Henry Johnson

Noah Robbins

Guest Star

Dennis Cockrum

Guest Star

Alex Borstein

Guest Star

Maggie Grace

Dr. Ethan Haas

Nicholas D'Agosto

Guest Star

Christian Clemenson

Guest Star

Sam McMurray

Dr. Lillian DePaul

Julianne Nicholson

Herb Spleeb

Jack Laufer

Guest Star

Jaeden Lieberher

Guest Star

Eve Gordon

Guest Star

Peter Douglas

Guest Star

Yvonne Zima

Helen Schiff

Sarah Silverman

Guest Star

Rob Benedict

Guest Star

Brian Howe

Guest Star

Keir O'Donnell

Guest Star

JB Blanc

Guest Star

Joe Tapper

Tessa Johnson

Kayla Madison

Guest Star

Carly Waldman

Chancellor Fitzhugh

Garrett M. Brown

Guest Star

Kristen Hager

Ronald Sturgis

Colin Woodell

Guest Star

Josh Charles

Guest Star

Christopher Wiehl

Guest Star

Christopher Grove

Guest Star

Eddie Jemison

Linda Einhorn

Hanna Hall

Guest Star

Simon Vance

Guest Star

Kevin Fonteyne

Guest Star

Jerry O'Donnell

Guest Star

Blake Morgan Ferris

Guest Star

Susan May Pratt

Guest Star

Grant Harvey

Guest Star

Jim Ortlieb

Guest Star

Julie Ann Emery

Guest Star

Timothy Durkin

Tessa Johnson

Isabelle Fuhrman

Donald Einhorn

Chris Dougherty

Jenny Masters

Alyvia Alyn Lind

Guest Star

Bruce Nozick

Guest Star

Danny Jacobs

Guest Star

Jonathan Kells Phillips

Guest Star

Colin Trahan

Henry Johnson

Cole Sand

Guest Star

Frances Fisher

Guest Star

Leo Marks

Margaret Scully

Allison Janney

Paul Edley

Benjamin Koldyke

Dr. Art Dreesen

Jeremy Strong

Dr. Nancy Leveau

Betty Gilpin

Vivian Scully

Rose McIver

Estabrooks Masters

Ann Dowd

Barbara Sanderson

Betsy Brandt

Flo Packer

Artemis Pebdani

Robert Franklin

Jocko Sims

Denny Keller

James Lujan

Bram Keller

David Walton

Delacourt

Liesel Kopp

Guy

Nick Clifford

Driver

Beau Berglund

Gene Moretti

Greg Grunberg

Clive Dundle

Casey E. Lewis

Louise Bell

Niecy Nash