Host
Derek Waters
Narrator
Tiffany Haddish
Deborah Sampson
Evan Rachel Wood
Guest Star
Seth Rogen
Gordon Cooper / Fred Rogers / Ernest Thompson Seton
Colin Hanks
Stetson Kennedy / Elisha Gray / Robert Wilson
Jason Ritter
Guest Star
Vanessa Hudgens
Guest Star
Tatiana Maslany
Guest Star
Randall Park
Guest Star
Questlove
Guest Star
Abbi Jacobson
Vincenzo Peruggia / Elvis Presley / William Mulholland
Jack Black
Guest Star
Mae Whitman
Guest Star
Kirsten Dunst
Narrator
Paget Brewster
Narrator
Amber Ruffin
Guest Star
Justin Long
Guest Star
Method Man
Rose Valland
Busy Philipps
Ponce De Leon / Marshall Ratliff / Johnny Cash
Johnny Knoxville
Guest Star
Kat Dennings
Guest Star
David Harbour
Guest Star
Vanessa Bayer
Guest Star
Allison Tolman
Guest Star
Josh Charles
Guest Star
Claudia O'Doherty
Guest Star
Lyric Lewis
Various
Bennie Arthur
Clara Barton
Mandy Moore
Guest Star
Raven-Symoné
Guest Star
Donald Faison
Edward Cope / Meriwether Lewis / James Monroe
Tony Hale
Guest Star
Jorma Taccone
Guest Star
Paul Scheer
Guest Star
Jimmy O. Yang
Guest Star
Amber Tamblyn
Guest Star
Ali Stroker
Various
Maria Blasucci
Guest Star
Kimiko Glenn
Guest Star
"Weird Al" Yankovic
Guest Star
Martin Starr
Various
Craig Cackowski
Guest Star
Joel McHale
Guest Star
Jane Krakowski
Guest Star
Samm Levine
Guest Star
Jillian Bell
Various
Jeremy J. Tutson
Various
Tymberlee Hill
Various
Sarah Burns
James Dunn
Alexander Skarsgård
— / H.R. Haldeman / General Andrew Jackson
Jack McBrayer
Various
Michael Daniel Cassady
Various
Adam Nee
King Charles II / Thomas Edison / Jim Bowie
Chris Parnell
D.B. Cooper / Frédéric Auguste Bartholdi / William Clark
Taran Killam
Scientist / Rough Rider / Bootlegger
Kyle David Crosby
Various / Fireman
Michael Coleman
Himself - Narrator / Museum Guard
Eric Edelstein