Jedediah Smith

Owen Wilson

Larry Daley

Ben Stiller

Teddy Roosevelt

Robin Williams

Kahmunrah / The Thinker / Abe Lincoln

Hank Azaria

Amelia Earhart

Amy Adams

Ivan the Terrible

Christopher Guest

Napoleon Bonaparte

Alain Chabat

Octavius

Steve Coogan

Dr. McPhee

Ricky Gervais

George Armstrong Custer

Bill Hader

Al Capone

Jon Bernthal

Nicky Daley

Jake Cherry

Ahkmenrah

Rami Malek

Sacajawea

Mizuo Peck

Neanderthal #1

Kerry van der Griend

Hun #2

Darryl Quon

Attila the Hun

Patrick Gallagher

Hun #3

Gerald Wong

Hun #4

Paul Chih-Ping Cheng

Sailor Joey Motorola

Jay Baruchel

Tuskegee Airman #2

Craig Robinson

Docent

Mindy Kaling

Tuskegee Airman #1

Keith Powell

Neanderthal #2

Matthew Harrison

Teenage Boy #1

Samuel Patrick Chu

Neanderthal #3

Rick Dobran

Hun #1

Randy Lee

Teenage Boy #2

Augustus Oicle

Teenage Boy #3

Kai James

Air and Space Mission Control Tech #2

Matty Finochio

George Foreman

George Foreman

Young Girl #2

Tess Levy

'American Gothic' Woman

Christina Schild

'American Gothic' Farmer

Robert Thurston

Kissing Nurse

Alberta Mayne

Oscar the Grouch (voice)

Caroll Spinney

Darth Vader

Thomas Morley

Town Car Driver

Dan Joffre

Air and Space Mission Control Tech #1

Clint Howard

New York Reporter

Regina Taufen

Capone Gangster #1

Josh Byer

Cherub #2 (voice)

Kevin Jonas

Young Girl #1

Sophie Levy

Cherub #3 (voice)

Nick Jonas

Albert Einstein (voice)

Eugene Levy

Larry Daley's Assistant (uncredited)

Ed Helms

Brundon the Security Guard (uncredited)

Jonah Hill

Kissing Sailor

Clifton MaCabe Murray

Dexter / Able (uncredited)

Crystal the Monkey

Astronaut

Dave Hospes

Infomercial Father

Shawn Levy

Cherub #1 (voice)

Joe Jonas

Easter Island Head (voice)

Brad Garrett

Director

Shawn Levy