Jackie Peyton

Edie Falco

Zoey Barkow

Merritt Wever

Dr. Cooper

Peter Facinelli

Eddie Walzer

Paul Schulze

Dr. Akalitus

Anna Deavere Smith

Kevin Peyton

Dominic Fumusa

Grace Peyton

Ruby Jerins

Officer Frank Verelli

Adam Ferrara

Thor Lundgren

Stephen Wallem

Fiona Peyton

Mackenzie Aladjem

Sam

Arjun Gupta

Mike Cruz

Bobby Cannavale

Lenny

Lenny Jacobson

Dr. Roman

Betty Gilpin

Dr. Eleanor O'Hara

Eve Best

Gabe

Michael Esper

Dr. Bernard Prince

Tony Shaloub

Dr. Wu

B.D. Wong

Johanes Karlsen

Jeremy Shamos

Vigilante Jones

Chris Elliott

Tress

Nilaja Sun

Barry Wolfe

Mark Feuerstein

Prentiss

Morris Chestnut

Vivian

Leslie Uggams

God / Donald

Michael Buscemi

Matt

Matthew Maher

Charlane

Tonya Pinkins

Marta

Marcy Harriell

Reuben

Kevin Cahoon

Guidry

John Ellison Conlee

Lydia

Vanessa Aspillaga

Trina

Meredith Holzman

Eddie's Deposition Lawyer

Michael Mulheren

Tazim

Purva Bedi

Mohammed 'Mo-Mo' De La Cruz

Haaz Sleiman

Patient

Rachel Hilson

Joe

Tim Guinee

Antoinette

Julie White

Rosa

Adriana DeGirolami

Paramedic

Katie Flahive

Ancient Italian Lady

Letty Serra

Donna

Kat Seelos

Susan

Cindy Cheung

Old Woman

Venida Evans

Gary Roberts

Steve Rosen

Fiona Peyton

Daisy Tahan

Young Administrator

Ali Ahn

Dr. Gill

Philip Hernandez

Reed

Garth Kravits

Lola

Ioana Alfonso

Mondra

Nina Hellman

Guest Star

Andrew Keenan-Bolger

Charlie Cruz

Jake Cannavale

Vinny Raven

James McMenamin

Woman

Cyndi Steele-Harrod

Kelly Slater

Gbenga Akinnagbe

Paramedic (as William Watkins) / Paramedic #2 (as William Watkins) / Paramedic #1 (as William Watkins)

William Oliver Watkins

Melissa Greenfield

Jill Flint