Captain Ed Mercer

Seth MacFarlane

Commander Kelly Grayson

Adrianne Palicki

Dr. Claire Finn

Penny Johnson Jerald

Lieutenant Gordon Malloy

Scott Grimes

Isaac

Mark Jackson

Lieutenant Commander Bortus

Peter Macon

Chief Security Officer Alara Kitan

Halston Sage

John LaMarr

J. Lee Morgan

Lieutenant John Lamarr

J. Lee

Yaphit (voice)

Norm Macdonald

Steve Newton

Larry Joe Campbell

Klyden

Chad L. Coleman

Talla Keyali

Jessica Szohr

Pria Lavesque

Charlize Theron

Admiral Tucker

Ron Canada

Lysella

Giorgia Whigham

Henry Park

Gavin Lee

Guest Star

Jeffrey Tambor

Captain Haros

Dylan Kenin

Dann

Mike Henry

Admiral Ozawa

Kelly Hu

Lieutenant Turco / Ensign Turco

Kyra Santoro

Hamelac

Robert Knepper

Sazeron

James Horan

Lewis

Loren Lester

Guest Star

Holland Taylor

Kaybrak

Lamont Thompson

Lieutenant Payne

Tim Mikulecky

Kemka

James Morrison

Ty Finn

Kai Wener

Captain Vorak

Deobia Oparei

Valondis

Lenny Von Dohlen

Teleya / Lt. Janel Tyler

Michaela McManus

Drenala Kitan

Molly Hagan

Tom

Barry Livingston

Tomilin

Max Burholder

Ildis Kitan

Robert Picardo

Chief Leidecker

Michael Dempsey

Willks

Steven Culp

Advocate Kagus

Antonio Charity

Baleth

Erica Tazel

Ogre

Patrick Cox

Marcus Finn

BJ Tanner

Drogen

Brian Thompson

Dr. Aronov

Brian George

Fadolin

Philip Anthony-Rodriguez

Computer (voice)

Rachael MacFarlane

Admiral Halsey

Victor Garber

Heveena

Rena Owen

Dr. Janice Lee

Christine Corpuz

Moclan Arbitrator

Jonathan Adams

Bruidian Ambassador

Derek Mears

Horbalak Captain

Paul Vogt

Moclan Council Foreman

D. Elliot Woods

Navarian Ambassador

J. Paul Boehmer

Derek

Sean Cook

Palovis

Michael Sielaff

Kanoot

Ralph Garman

Krill Captain

Joel Swetow

Charly Burke

Anne Winters

Topa

Blesson Yates

Brosk

Jim Mahoney

Kaylon Primary / Kaylon / K-1

Graham Hamilton

Admiral Perry

Ted Danson

Cassius

Chris Johnson

Darulio

Rob Lowe

Nurse Hopkins

Sarah Jane MacKay

Isaac

Ron Kurz