Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Evil Stewie / Kool-Aid Guy

Seth MacFarlane

Lois Griffin / Tricia Takanawa / Loretta Brown

Alex Borstein

Chris Griffin

Seth Green

Meg Griffin

Mila Kunis

Cleveland Brown (voice) / Bruce the Performance Artist (voice) / (voice)

Mike Henry

Himself

Rush Limbaugh

Joe Swanson (voice) / Joe Swanson as Wise Man (voice) / Joe Swanson

Patrick Warburton

Himself

Rainn Wilson

Vatican Messenger

Joe Flaherty

Carol Brady

Shelley Long

Himself

Bill Maher

Channel 5 Jingle Singer

Helen Reddy

Adam West (voice) / Mayor Adam West / Fairy Godmother (voice)

Adam West

Bonnie Swanson (voice)

Jennifer Tilly

Horace

Johnny Brennan

Himself

Robert Loggia

Bertram

Wallace Shawn

Herself

Cheryl Tiegs

Black Sassy Nurse

Yvette Nicole Brown

Baby Susie Swanson (Inner Voice) (voice) / Narrator (voice) / Captain Jean-Luc Picard (voice)

Patrick Stewart

Jerome (voice) / (voice) / Cleveland Brown Jr. (voice)

Kevin Michael Richardson

Angela (voice) / Angela as Mon Mothma (voice)

Carrie Fisher

Herself

Arianna Huffington

Carol Pewterschmidt

Julie Hagerty

Death (voice) / Death / Super Death (voice)

Adam Carolla

Principal Shepherd (voice) / Reporter (voice) / Mike Brady (voice)

Gary Cole

Hot Blonde

Anne Hathaway

Another Death (voice) / Announcer (voice) / TV Announcer (voice)

John Viener

James Woods (voice) / James Woods as General Veers (voice) / Family Guy James Woods

James Woods

(voice) / Various (voice) / Cashier (voice)

Rachael MacFarlane

Himself

Dana Gould

Himself

Drew Carey

Connie D'Amico (voice) / Beth / Teenage Girl (voice)

Lisa Wilhoit

Additional Voices

Megan Grano

Man (voice) / Various (voice) / Jeff Campbell

Chris Cox

Asian Student #1 / Asian Student #2 (voice) / Tour Guide (voice)

Robert Wu

(voice) / First Caterpillar / Man

Kirker Butler

Esther (voice)

Christina Milian

Abby / Little Girl

Karley Scott Collins

Lois' High School Bully

Nina Dobrev

Club Manager

Luke Adams

Additional Voices

Aaron Krebs

(voice) / Ernie the Giant Chicken (voice) / Announcer (voice)

Danny Smith

Himself (archive footage)

David Bowie

Additional Voices

Alan Tudyk

Kelly

Ashley Tisdale

Teenage Girl

Sarah Ramos

(voice) / Rita (voice) / Mother (voice)

Nana Visitor

(voice) / Jesus Christ (voice) / Man (voice)

Alec Sulkin

John McCain

Fred Tascatore

Diane Simmons / Girl (voice) / Diane Simmons as Imperial Newscaster (voice)

Lori Alan

(voice) / Kid (voice) / Randall (voice)

Colin Ford

Patty

Barclay DeVeau

(voice) / Peter's Customer / Tea Party Member (voice)

Patrick Meighan

Ollie Williams (voice) / Judge (voice) / (voice)

Phil LaMarr

Himself

David Boreanaz

Himself (archive footage)

Mick Jagger

Joyce Kinney (voice) / (voice) / Joyce Kinney

Christine Lakin

Jan

Katie Sah

Jillian Russell (voice) / Mrs. Lockhart (voice)

Drew Barrymore

(voice) / Squirrel (voice) / Male Bat (voice)

Dee Bradley Baker

Ruth Cochamer (voice)

Natasha Melnick

Denise

Jessica Stroup

Steven Keaton

Michael Gross

Elyse Keaton

Meredith Baxter

Megatron

Frank Welker

Jenny

Laura Vandervoort

(voice) / Police Officer (voice) / Various (voice)

Ralph Garman

(voice) / Muriel Goldman (voice) / Mrs. Goldman (voice)

Nicole Sullivan

Carl (voice) / Bob Belcher (voice) / Carl as Yoda (voice)

H. Jon Benjamin

Cleveland Brown (voice)

Arif Zahir

Additional Voices

Kaitlin Olson

(voice) / Student #3 (voice) / Patient (voice)

Steve Callaghan

Kid (voice) / (voice) / Young Patrick Pewterschmidt (voice)

Max Burkholder

Additional Voices

Alex Breckenridge

Bully

James Burkholder

Narrator

Ron MacFarlane

Additional Voices

Alexa Nikolas

Additional Voices

Wellesley Wild

Santa Claus

Bruce McGill

(voice) / Smurf #2 (voice) / Green Monster (voice)

Mike Barker

Additional Voices

Chris Edgerly

(voice) / Sportscasters (voice) / Peter's Customer

Julius Sharpe

Winnie the Pooh

Will Ryan

Charles (archive footage)

Scott Baio

Buddy Lembeck (archive footage)

Willie Aames

Bully

Noah Matthews

Mort Goldman (voice) / Horace (voice) / Man #2 (voice)

John G. Brennan

Sarah Powell (archive footage)

Josie Davis

Jamie Powell (archive footage)

Nicole Eggert

(voice) / Morgan Freeman (voice) / Aaron Sorkin (voice)

Josh Robert Thompson

(voice) / Meg Griffin (voice)

Lacey Chabert

Additional Voices

Lyndon Smith

Ellen Powell (archive footage)

Sandra Kerns

(voice) / Corey (voice) / Cody Spraytan (voice)

Damien Fahey

Kid

David Gore

Lieutenant Worf

Michael Dorn

Additional Voices

J. Lee

(voice) / Half-Dead Fat Guy (voice) / Deep Sea Trainer #1

Chris Sheridan

Herself

Mary Hart