Phillip J. Fry/Profesor Hubert Farnsworth/Dr. John Zoidberg

Billy West

Turanga Leela

Katey Sagal

Bender

John DiMaggio

Mom/Linda/Munda

Tress MacNeille

Amy Wong (voice)

Lauren Tom

Lt. Kif Kroker/Morbo/Calculon

Maurice LaMarche

Hermes Conrad (voice)

Phil LaMarr

Larry/Roberto

Dave Herman

Cubert Farnsworth

Kath Soucie*

LaBarbara Conrad (voice) / Jackie Anderson (voice)

Dawnn Lewis

Nibbler (voice) / Tardigrades (voice) / Nibbler

Frank Welker

Robot Devil (voice)

Dan Castellaneta

Yivo

David Cross

Himself

Snoop Dogg

Frida Waterfall/Hutch Waterfall/The Encyclopod

Phil Hendrie

Himself

Stephen Hawking

Himself

Gary Gygax

Himself

Rich Little

Mars Vegas Singer

Seth MacFarlane

Kwanzaabot (voice)

Coolio

Colleen O'Hallahan

Brittany Murphy

Yancy Fry Jr. (voice)

Tom Kenny

George Takei's Head (voice)

George Takei

Themselves

Penn & Teller

Al Gore (voice)

Al Gore

Chanukah Zombie

Mark Hamill

Leonard Nimoy's Head (Voice)

Leonard Nimoy

Leo Wong (voice) / Scoop Chang (voice)

Feodor Chin

URL (voice) / Barbados Slim (voice) / (voice)

Kevin Michael Richardson