Fry/Prof. Farnsworth/Dr. Zoidberg
Billy West*
Phillip J. Fry/Profesor Hubert Farnsworth/Dr. John Zoidberg
Billy West
Turanga Leela
Katey Sagal
Bender (voice)
John DiMaggio
Mom/Linda/Munda
Tress MacNeille
Amy Wong (voice)
Lauren Tom
Lt. Kif Kroker/Morbo/Calculon
Maurice LaMarche
Hermes Conrad (voice)
Phil LaMarr
Scruffy/C. Randall Poopenmeyer/Morris
David Herman
LaBarbara Conrad (voice) / Jackie Anderson (voice)
Dawnn Lewis
Michelle / Rude Boy / Head Museum Feeder (voice)
Kath Soucie
Robot Devil (voice)
Dan Castellaneta
Nibbler (voice) / Tardigrades (voice) / Nibbler
Frank Welker
Yivo
David Cross
Himself
Snoop Dogg
Frida Waterfall/Hutch Waterfall/The Encyclopod
Phil Hendrie
Himself
Stephen Hawking
Himself
Gary Gygax
Himself
Rich Little
Mars Vegas Singer
Seth MacFarlane
Kwanzaabot (voice)
Coolio
Colleen O'Hallahan
Brittany Murphy
Yancy Fry Jr. (voice)
Tom Kenny
George Takei's Head (voice)
George Takei
Themselves
Penn & Teller
Al Gore (voice)
Al Gore
Chanukah Zombie
Mark Hamill
Leonard Nimoy's Head (Voice)
Leonard Nimoy
Leo Wong (voice) / Scoop Chang (voice)
Feodor Chin
URL (voice) / Barbados Slim (voice) / (voice)
Kevin Michael Richardson