Phillip J. Fry/Profesor Hubert Farnsworth/Dr. John Zoidberg

Billy West

Turanga Leela

Katey Sagal

Bender

John DiMaggio

Mom/Linda/Munda

Tress MacNeille

Amy Wong (voice)

Lauren Tom

Lt. Kif Kroker/Morbo/Calculon

Maurice LaMarche

Hermes Conrad (voice)

Phil LaMarr

Larry/Roberto

Dave Herman

Cubert Farnsworth (voice) / Princess Num Num (voice) / Cubert Farnsworth

Kath Soucie

LaBarbara Conrad (voice) / LaBarbara Conrad / Hermes' Mother (voice)

Dawnn Lewis

Nibbler

Frank Welker

Robot Devil (voice) / The Robot Devil (voice)

Dan Castellaneta

Yivo

David Cross

Himself

Snoop Dogg

Frida Waterfall/Hutch Waterfall/The Encyclopod

Phil Hendrie

Himself

Stephen Hawking

Himself

Gary Gygax

Himself

Rich Little

Mars Vegas Singer

Seth MacFarlane

Kwanzaabot (voice)

Coolio

Colleen O'Hallahan

Brittany Murphy

George Takei's Head (voice)

George Takei

Themselves

Penn & Teller

Al Gore (voice)

Al Gore

Yancy Fry Jr. (voice) / Abner Doubledeal (voice) / Abner Doubledeal

Tom Kenny

URL (voice) / Barbados Slim (voice) / URL

Kevin Michael Richardson

Chanukah Zombie

Mark Hamill

Leo Wong (voice) / Scoop Chang (voice)

Feodor Chin

Gamester Alien #2 / Donkey Monster (voice) / Snipe (voice)

Dee Bradley Baker

TV Special Screams (voice) / Owl (voice) / Cara Delevingne (voice)

Cara Delevingne