Sherlock Holmes
Jonny Lee Miller
Joan Watson
Lucy Liu
Captain Thomas Gregson
Aidan Quinn
Detective Marcus Bell
Jon Michael Hill
Odin Reichenbach
James Frain
Zachary Fowler
Danny Binstock
Detective Owen Calabrissi
Joseph Lyle Taylor
George Eagen
John Sharian
Captain Dwyer
Rob Bartlett
Dr. Eugene Hawes / Dr. Eugene Hawes
Jordan Gelber
Morland Holmes
John Noble
Kitty Winter
Ophelia Lovibond
Lanette Brooklee
Mandy Gonzalez
Paige
Virginia Madsen
DCI Athelney Jones
Tamsin Greig
Detective Farrad
Marjan Neshat
Annie Spellman
Kristen Bush
Ellory
Wrenn Schmidt
Tara Parker
Sutton Foster
Erika Vanderwey
Patricia Kalember
Agent Dean McNally
Tim Guinee
Naomi Long
Liz Carey
Sebastian Florenti
Gabriel Ebert
Antoine LaGrange
Daniel Davis
Colby
Nick Rehberger
Dr. Angela Hardy
Lindsay Mendez
Dr. Garret Halsey
Ravi Kapoor
Davis Whitmark
Myk Watford
Patrick Meers
Mac Brandt
Meredith Sagehorn
Christa Scott-Reed
Stewart Pringle/Wilson Kubiak
Charlie Semine
Antonia
Rachael Holmes
Olga Berezhnaya
Lili Mirojnick
Danielle Olivera
Kate Shindle
Ronald Adair
Simon Templeman
Tremaine
Terry Bell
Mrs. Tseng
Jodi Long
Mr. Hutchins
Michael Bryan French
Judd Foley
Charles Borland
Jason Wood
Chris Diamantopoulos
Hernan Zielenko
Robert Neary
Bree Novacek
Emily Swallow
Carla Whitmark
Stephanie DiMaggio
Ruby Carville
Saffron Burrows
Frederick Wentz
Bob Gunton
Lola Quinn
Maritz Veer
Mack Leehoven
Matthew Boston
Alejandro
Armando Acevedo
A.D.A. Garrison
Michael Hayden
Alfredo Llamosa
Ato Essandoh
Edward Cutler
David Beach
Derek Casey
Jamie Thomas King
Marty Bledsoe
Mike Houston
Dr. Gregory Burgess
Peter Ganim
Audrey Kensit
Shirley Rumierk
Sean
Ian Palmer
Wesley Conrad
Roderick Hill
Beth
Samantha Massell
Amos Deukmejian/DJ Pandasalt
Josiah Bania
Mycroft Holmes
Rhys Ifans
Aura Swenson
Kate Middleton
Jim Bendix
William Hill
Tony
Dave Shalansky
Enrique Ruiz
Carlos Gómez
Stan Veek
Zachary Knower
Chloe
January LaVoy
Janice
Kristolyn Lloyd
Rose
Shamika Cotton
Lisa Cooper
Kimberly S. Fairbanks
Tessa Pritchard
Kelly McCrann
Claire
Emma Kikue
Chip
Danny Schwarz
News Host
Joan Lunden
Detective Ocasio
Tramell Tillman
Security Coordinator
Andre Blake
Alwyn Smith
Ian Kahn
Beppo
Federico Dordei
Linda Blumenthal
April Ortiz
Caroline Gibbs
Carol Halstead
Mason
Robert Capron
Aura's Lawyer
Kate Levy
Eldon
Eric Elizaga
Ridley Dineen
Jason Babinsky
Jessi McNally
Nora Murphy
Peyton Trask
Brent Langdon
Guest 1
Stephen Dexter
Dalton Weller
Michael Satow
Arthur
Jonathan Han
Michael Bowen / Michael
Desmond Harrington
Nurse
Tara Summers
Lawyer
Mary McCann
Mr. Balfour
Alex Cranmer
Gene
Kristoffer Cusick
Lawyer
Judy McLane
Jake Goodel
Bubba Weiler
Amir
Sathya Sridharan
Ethiopian Consul
Lisa Arrindell
Guide
An-Li Bogan
Italian Woman
Caprice Benedetti
Lawyer
James Murtaugh
ToddHarris
Jeff Applegate
Officer Saldenbrook
Kario Marcel
Moped Man
Tom Vickers
Dylan Halleran
Sea McHale
Customer Service Rep
Tiffany Villarin
Cassie Lenue
Allie Ioannides
Esther Kelton
Pamela Dunlap
Suited Detective
Luis Moreno
Corinna Wood
Maddie Jo Landers
Reporter 1
Harry Smith
Viola Wright
Harriett D. Foy
Jersey Shore
Cody Calafiore
Propane Salesman
Gabe Doran
Lead ESU Officer
Yaegel T. Welch
Moped Man
Tom Vickers
ESU Sergeant
Diego Aguirre
Chip
Danny Schwarz
Assistant
Phumzile Sitole
Social Worker
Kelsey Rainwater
Mrs. Conrad
Lizbeth MacKay
Ms. Duarte
Maria Elena Ramirez
Irene Adler / Jamie Moriarty / Jamie Moriarty (voice)
Natalie Dormer
Plainclothes Cop
Mike Keller
Girlfriend
Autumn Guzzardi
Nicholas Gerrardi
Nathaniel Stampley
Benjamin Long
Joe Tippett
FBI Security Officer
Terrell Wheeler
Durah
Woodlene Alexis
Reporter 2
Ian Harkins
Reporter #1
Harry Smith
Cassina
Jennifer Mudge
Hannah Gregson
Liza J. Bennett
Team Leader
Jonathan Sale
Reporter #2
Ian Harkins
Lola Quinn
Maritza Veer
Arnold
Christopher Reed Brown
Juliana
Kirsten Scott
Carson Mayfield
Michael Siberry
Nurse
Erica Bradshaw
Chantal Milner
Chasten Harmon
Libby
Brynne McManimie
Elise
Winsome Brown
Sasha
Alyson Lange
Driver
Paco Lozano
Alicia Ocacia
Jade Radford
Andrew Paek
Raza Jaffrey
Guard 1
Marc Webster
TV Reporter / Reporter / TV News Anchor
Kristine Johnson