Sherlock Holmes
Jonny Lee Miller
Joan Watson
Lucy Liu
Captain Thomas Gregson
Aidan Quinn
Detective Marcus Bell
Jon Michael Hill
Shinwell Johnson
Nelsan Ellis
Guest Star
Chris McKinney
Guest Star
Wade Williams
Guest Star
Debi Mazar
Guest Star
Jon Huertas
Councilman Slessinger
John Doman
Dr. Eugene Hawes / Dr. Eugene Hawes
Jordan Gelber
Guest Star
Samantha Quan
Nathan Resor
Matthew Del Negro
Guest Star
Owain Yeoman
Morland Holmes
John Noble
Kitty Winter
Ophelia Lovibond
Tyus Wilcox
Stephen Rider
Guest Star
Conor Leslie
Guest Star
Robert Capron
Guest Star
Virginia Madsen
Chantal Milner
Chasten Harmon
Brenda Resor
Bianca Amato
Thea Moser
Michele Hicks
Bonzi Folsom
Al Thompson
Ted Winthrop
Danny Burstein
Guest Star
Isiah Whitlock Jr.
Guest Star
Raymond Ma
Titus Gorham
Matthew Lawler
Guest Star
Deirdre Lovejoy
Guest Star
Matthew Rauch
Guest Star
Zachary Knighton
Guest Star
Dorian Missick
Guest Star
James Kyson
Guest Star
Robert Christopher Riley
Tara Parker
Sutton Foster
Guest Star
Betty Gilpin
Guest Star
Emily Dorsch
Guest Star
Laura Heisler
Eli Kotite
Michael Patrick Thornton*
Guest Star
Lorenzo Pisoni
Agent Dean McNally
Tim Guinee
Louis Garmendia
Dan Lauria
Guest Star
Rob McClure
Guest Star
Jonathan Freeman
Guest Star
Jake Brinskele
Angela Newsome
Leslie Fray
Guest Star
Christine Taylor
Guest Star
Debra Jo Rupp
Virginia Spivey
Rebecca Luker
Dr. Wilkerson
Regina Taylor
Guest Star
Kim Director
Guest Star
Susan Blommaert
Guest Star
Frank Whaley
Guest Star
Shuler Hensley
Ardy Gulbenkian
Michael Berresse
Sydney Garber
Alan Rosenberg
Guest Star
Anna Khaja
Guest Star
Richard Thomas
Cosmo
Henry Zebrowski
Cray Fielder
Lee Tergesen
Guest Star
Haynes Thigpen
May
Joanna Christie
Guest Star
Derek Goh
Guest Star
Luna Tieu
Guest Star
Ishmail Bashey
Guest Star
Rosa Gilmore
Guest Star
Tina Chilip
Guest Star
William Ragsdale
Fyodor Ukhov
Olek Krupa
Paul Fontino
Paul O'Brien
Guest Star
Elizabeth Ward Land
Guest Star
Philip Casnoff
Markham
Joey Sorge
Guest Star
Curtiss Cook
Guest Star
Francis Jue
Guest Star
Brian Hutchison
Guest Star
Teddy Cañez
Kate Durning
Blair Brown
Guest Star
Bridget Ann White
Guest Star
Brian Muller
Guest Star
Jacob Alexander
Tom
Jacob Alexander
Guest Star
Simon Belz
Denton Clark
Julian Elijah Martinez
Guest Star
Darlesia Cearcy
Guest Star
Peterson Townsend
Margaret
Marianne Muellerleile
Guest Star
David Aaron Baker
Rueben Drexel
Carson Elrod
Alfredo Llamosa
Ato Essandoh
Lara Ukhov
Kelly Deadmon
Guest Star
Jeff McCarthy
Guest Star
Quincy Dunn-Baker
Claude Rysher/Razr
Ryan Oakes
Guest Star
Ron Rifkin
Guest Star
Bobby Moreno
Guest Star
Kia Goodwin
Guest Star
Ka-Ling Cheung
Guest Star
Gordon Clapp
Guest Star
Anthony DeSando
Guest Star
Ruffin Prentiss
Guest Star
Rodney Richardson
Mycroft Holmes
Rhys Ifans
Kid
Simon Belz
Guest Star
Delia Cunningham
Guest Star
Dan Ziskie
Keating
Maury Ginsberg
Nelson Lewis
Clark Jackson
Emily Gray
Iris Bahr
Guest Star
Fran Kranz
Guest Star
Alfredo Narciso
Guest Star
Linda Powell
Joseph Tommolino
Delaney Williams
Guest Star
Gideon Glick
Guest Star
Shelley Thomas
Taxi Driver
Irungu Mutu
Guest Star
Jason Bowen
Marco
Marcus Choi
Guest Star
Jaime Lincoln Smith
Guest Star
Cary Donaldson
Guest Star
Charlie Pollock
Anson Gephardt
Scott Shepherd
Guest Star
Holly Chou
Sedan Driver
Antonio Edwards Suarez
Receptionist
Rachel Christopher
Guest Star
Stephanie Jean Lane
Guest Star
Tony Roach
Houston Spivey
David Corenswet
Guest Star
Julian Acosta
Guest Star
Eddie McGee
Detective Perkins
Daryl Edwards
Guest Star
Tonye Patano
Priest
Wilbur Fitzgerald
Guest Star
Myra Lucretia Taylor
Reese Vennek
Tommy Schrider
Guest Star
Lee Sellars
Guest Star
Antonio Edwards Suarez
Guest Star
Annie Q
Guest Star
Catherine Blades
Guest Star
Ito Aghayere
Guest Star
John Bolton
Guest Star
Stacey Sargeant
Guest Star
Wendell B. Franklin
Josh
Ben Biggers
Lela
Rachel Wenitsky
Rochelle
Toni Ann DeNoble
Guest Star
Stephen Chacon
Guest Star
Daniel Cosgrove
Guest Star
Barry Shabaka Henley
Michael Bowen / Michael
Desmond Harrington
Guest Star
Burke Moses
Guest Star
Victor Verhaeghe
Maureen
Marnie Schulenburg
Guest Star
Andrew Manning
Guest Star
John Rue
Guest Star
Rosie Benton
Guest Star
Flor De Liz Perez
Guest Star
Mark Tallman
Guest Star
Leopold Manswell
CSU Officer
Rafael Poueriet
Marjorie
Chelsea Spack
Cable News Anchor
Marlie Hall
FBI Agent 1
Connor Bond
Guest Star
Todd Lawson
Guest Star
Mitch Greenberg
Guest Star
Alisa Ermolaev
Vicki
Zainab Jah
Mrs. Azoff
Diane Davis
Guest Star
Damian Young
Guest Star
Robert Cuccioli
Glenn
Patrick Boll
Ballard Clifton
Jason Butler Harner
Guest Star
Jane Alexander
Guest Star
Bianca Amato
Uniform 1
Adrian Alvarado
Guest Star
Graham Rowat
Guest Star
Jill Paice
Guest Star
Suzy Jane Hunt
Odin Reichenbach
James Frain
Stylist
Gregory Haney
Guest Star
Jeremy Burnett
Guest Star
Ryan Garbayo
Guest Star
Samuel Gomez
Guest Star
Pierre Jean Gonzalez
Female EMT
Lilli Cooper
Gunther Klecko
Matthew F. O'Connor
Uniform Officer
Jude Tibeau
Herman Wolf
Meat Loaf Aday
Guest Star
Kathy Najimy
Guest Star
Steven Taylor
Guest Star
Bill Dawes
Guest Star
Opal Alladin
Frye
James Joseph O'Neil
Guest Star
Deidre Goodwin
Guest Star
Yassmin Alers
FBI Agent 2
Steve Key
Guest Star
Ebrahim Jaffer
Guest Star
Maechi Aharanwa
Guest Star
Ruthie Ann Miles
Beautiful Woman
Charlbi Dean Kriek
Guest Star
Arnold Y. Kim
Receptionist
Jenelle Chu
Guest Star
Rachel York
Tom Saunders, V.O.
Jim Piddock
Guest Star
Katie Kreisler
Guest Star
Edward Carnevale
Doctor
Megan Byrne
Guest Star
Andrea Frierson
Irene Adler / Jamie Moriarty / Jamie Moriarty (voice)
Natalie Dormer
Bethesda
Chivonne Michelle
Guest Star
Kristen Adele
Guest Star
Ryan Andes*
Guest Star
Patricia R. Floyd
Darren Azoff
Danny Wolohan
Guest Star
Joaquin Maceo Rosa
Guest Star
Michael Mulheren
Shopkeep
Ching Valdes-Aran
Guest Star
Sendhil Ramamurthy
Hannah Gregson
Liza J. Bennett
Guest Star
Jessica Savage
Male Staffer
Justin Adams
Guest Star
Peter Onorati
Guest Star
Sam Breslin Wright
Guest Star
Kelly McAndrew
Guest Star
Madai Chakell
Guest Star
Pia Haddad
CSU Tech
Kathryn Allison
Guest Star
Marcella Lowery
Guest Star
Connor Johnston
Guest Star
Luis Moreno
Guest Star
Deshawn Harold Mitchell
Guest Star
Tyrone Mitchell Henderson
Guest Star
Jeff Kready
Guest Star
Olesya Senchenko
Guest Star
Raphael Nash Thompson
Captain Dwyer
Rob Bartlett
Guest Star
Hendrick Pilar
Andrew Paek
Raza Jaffrey
Guest Star
Sandy Rosenberg
Guest Star
Arturo Sanchez
TV Reporter / Reporter / TV News Anchor
Kristine Johnson
Guest Star
Jean Brassard
Guest Star
Jordan "JKap" Kaplan
Guest Star
Tarik Celik
Guest Star
Ryan Coker-Welch
Linda Emond
Susan Pourfar
Katherine Heigl