Sherlock Holmes

Jonny Lee Miller

Joan Watson

Lucy Liu

Captain Thomas Gregson

Aidan Quinn

Detective Marcus Bell

Jon Michael Hill

Shinwell Johnson

Nelsan Ellis

Guest Star

Chris McKinney

Guest Star

Wade Williams

Guest Star

Debi Mazar

Guest Star

Jon Huertas

Councilman Slessinger

John Doman

Dr. Eugene Hawes / Dr. Eugene Hawes

Jordan Gelber

Guest Star

Samantha Quan

Nathan Resor

Matthew Del Negro

Guest Star

Owain Yeoman

Morland Holmes

John Noble

Kitty Winter

Ophelia Lovibond

Tyus Wilcox

Stephen Rider

Guest Star

Conor Leslie

Guest Star

Robert Capron

Guest Star

Virginia Madsen

Chantal Milner

Chasten Harmon

Brenda Resor

Bianca Amato

Thea Moser

Michele Hicks

Bonzi Folsom

Al Thompson

Ted Winthrop

Danny Burstein

Guest Star

Isiah Whitlock Jr.

Guest Star

Raymond Ma

Titus Gorham

Matthew Lawler

Guest Star

Deirdre Lovejoy

Guest Star

Matthew Rauch

Guest Star

Zachary Knighton

Guest Star

Dorian Missick

Guest Star

James Kyson

Guest Star

Robert Christopher Riley

Tara Parker

Sutton Foster

Guest Star

Betty Gilpin

Guest Star

Emily Dorsch

Guest Star

Laura Heisler

Eli Kotite

Michael Patrick Thornton*

Guest Star

Lorenzo Pisoni

Agent Dean McNally

Tim Guinee

Louis Garmendia

Dan Lauria

Guest Star

Rob McClure

Guest Star

Jonathan Freeman

Guest Star

Jake Brinskele

Angela Newsome

Leslie Fray

Guest Star

Christine Taylor

Guest Star

Debra Jo Rupp

Virginia Spivey

Rebecca Luker

Dr. Wilkerson

Regina Taylor

Guest Star

Kim Director

Guest Star

Susan Blommaert

Guest Star

Frank Whaley

Guest Star

Shuler Hensley

Ardy Gulbenkian

Michael Berresse

Sydney Garber

Alan Rosenberg

Guest Star

Anna Khaja

Guest Star

Richard Thomas

Cosmo

Henry Zebrowski

Cray Fielder

Lee Tergesen

Guest Star

Haynes Thigpen

May

Joanna Christie

Guest Star

Derek Goh

Guest Star

Luna Tieu

Guest Star

Ishmail Bashey

Guest Star

Rosa Gilmore

Guest Star

Tina Chilip

Guest Star

William Ragsdale

Fyodor Ukhov

Olek Krupa

Paul Fontino

Paul O'Brien

Guest Star

Elizabeth Ward Land

Guest Star

Philip Casnoff

Markham

Joey Sorge

Guest Star

Curtiss Cook

Guest Star

Francis Jue

Guest Star

Brian Hutchison

Guest Star

Teddy Cañez

Kate Durning

Blair Brown

Guest Star

Bridget Ann White

Guest Star

Brian Muller

Guest Star

Jacob Alexander

Tom

Jacob Alexander

Guest Star

Simon Belz

Denton Clark

Julian Elijah Martinez

Guest Star

Darlesia Cearcy

Guest Star

Peterson Townsend

Margaret

Marianne Muellerleile

Guest Star

David Aaron Baker

Rueben Drexel

Carson Elrod

Alfredo Llamosa

Ato Essandoh

Lara Ukhov

Kelly Deadmon

Guest Star

Jeff McCarthy

Guest Star

Quincy Dunn-Baker

Claude Rysher/Razr

Ryan Oakes

Guest Star

Ron Rifkin

Guest Star

Bobby Moreno

Guest Star

Kia Goodwin

Guest Star

Ka-Ling Cheung

Guest Star

Gordon Clapp

Guest Star

Anthony DeSando

Guest Star

Ruffin Prentiss

Guest Star

Rodney Richardson

Mycroft Holmes

Rhys Ifans

Kid

Simon Belz

Guest Star

Delia Cunningham

Guest Star

Dan Ziskie

Keating

Maury Ginsberg

Nelson Lewis

Clark Jackson

Emily Gray

Iris Bahr

Guest Star

Fran Kranz

Guest Star

Alfredo Narciso

Guest Star

Linda Powell

Joseph Tommolino

Delaney Williams

Guest Star

Gideon Glick

Guest Star

Shelley Thomas

Taxi Driver

Irungu Mutu

Guest Star

Jason Bowen

Marco

Marcus Choi

Guest Star

Jaime Lincoln Smith

Guest Star

Cary Donaldson

Guest Star

Charlie Pollock

Anson Gephardt

Scott Shepherd

Guest Star

Holly Chou

Sedan Driver

Antonio Edwards Suarez

Receptionist

Rachel Christopher

Guest Star

Stephanie Jean Lane

Guest Star

Tony Roach

Houston Spivey

David Corenswet

Guest Star

Julian Acosta

Guest Star

Eddie McGee

Detective Perkins

Daryl Edwards

Guest Star

Tonye Patano

Priest

Wilbur Fitzgerald

Guest Star

Myra Lucretia Taylor

Reese Vennek

Tommy Schrider

Guest Star

Lee Sellars

Guest Star

Antonio Edwards Suarez

Guest Star

Annie Q

Guest Star

Catherine Blades

Guest Star

Ito Aghayere

Guest Star

John Bolton

Guest Star

Stacey Sargeant

Guest Star

Wendell B. Franklin

Josh

Ben Biggers

Lela

Rachel Wenitsky

Rochelle

Toni Ann DeNoble

Guest Star

Stephen Chacon

Guest Star

Daniel Cosgrove

Guest Star

Barry Shabaka Henley

Michael Bowen / Michael

Desmond Harrington

Guest Star

Burke Moses

Guest Star

Victor Verhaeghe

Maureen

Marnie Schulenburg

Guest Star

Andrew Manning

Guest Star

John Rue

Guest Star

Rosie Benton

Guest Star

Flor De Liz Perez

Guest Star

Mark Tallman

Guest Star

Leopold Manswell

CSU Officer

Rafael Poueriet

Marjorie

Chelsea Spack

Cable News Anchor

Marlie Hall

FBI Agent 1

Connor Bond

Guest Star

Todd Lawson

Guest Star

Mitch Greenberg

Guest Star

Alisa Ermolaev

Vicki

Zainab Jah

Mrs. Azoff

Diane Davis

Guest Star

Damian Young

Guest Star

Robert Cuccioli

Glenn

Patrick Boll

Ballard Clifton

Jason Butler Harner

Guest Star

Jane Alexander

Guest Star

Bianca Amato

Uniform 1

Adrian Alvarado

Guest Star

Graham Rowat

Guest Star

Jill Paice

Guest Star

Suzy Jane Hunt

Odin Reichenbach

James Frain

Stylist

Gregory Haney

Guest Star

Jeremy Burnett

Guest Star

Ryan Garbayo

Guest Star

Samuel Gomez

Guest Star

Pierre Jean Gonzalez

Female EMT

Lilli Cooper

Gunther Klecko

Matthew F. O'Connor

Uniform Officer

Jude Tibeau

Herman Wolf

Meat Loaf Aday

Guest Star

Kathy Najimy

Guest Star

Steven Taylor

Guest Star

Bill Dawes

Guest Star

Opal Alladin

Frye

James Joseph O'Neil

Guest Star

Deidre Goodwin

Guest Star

Yassmin Alers

FBI Agent 2

Steve Key

Guest Star

Ebrahim Jaffer

Guest Star

Maechi Aharanwa

Guest Star

Ruthie Ann Miles

Beautiful Woman

Charlbi Dean Kriek

Guest Star

Arnold Y. Kim

Receptionist

Jenelle Chu

Guest Star

Rachel York

Tom Saunders, V.O.

Jim Piddock

Guest Star

Katie Kreisler

Guest Star

Edward Carnevale

Doctor

Megan Byrne

Guest Star

Andrea Frierson

Irene Adler / Jamie Moriarty / Jamie Moriarty (voice)

Natalie Dormer

Bethesda

Chivonne Michelle

Guest Star

Kristen Adele

Guest Star

Ryan Andes*

Guest Star

Patricia R. Floyd

Darren Azoff

Danny Wolohan

Guest Star

Joaquin Maceo Rosa

Guest Star

Michael Mulheren

Shopkeep

Ching Valdes-Aran

Guest Star

Sendhil Ramamurthy

Hannah Gregson

Liza J. Bennett

Guest Star

Jessica Savage

Male Staffer

Justin Adams

Guest Star

Peter Onorati

Guest Star

Sam Breslin Wright

Guest Star

Kelly McAndrew

Guest Star

Madai Chakell

Guest Star

Pia Haddad

CSU Tech

Kathryn Allison

Guest Star

Marcella Lowery

Guest Star

Connor Johnston

Guest Star

Luis Moreno

Guest Star

Deshawn Harold Mitchell

Guest Star

Tyrone Mitchell Henderson

Guest Star

Jeff Kready

Guest Star

Olesya Senchenko

Guest Star

Raphael Nash Thompson

Captain Dwyer

Rob Bartlett

Guest Star

Hendrick Pilar

Andrew Paek

Raza Jaffrey

Guest Star

Sandy Rosenberg

Guest Star

Arturo Sanchez

TV Reporter / Reporter / TV News Anchor

Kristine Johnson

Guest Star

Jean Brassard

Guest Star

Jordan "JKap" Kaplan

Guest Star

Tarik Celik

Guest Star

Ryan Coker-Welch

Linda Emond

Susan Pourfar

Katherine Heigl

Director

Aidan Quinn

Director

Jennifer Lynch

Director

Lucy Liu

Director

Guy Ferland

Director

Christine Moore

Director

Aaron Lipstadt

Director

Michael Slovis

Director

Jeremy Webb

Director

Seith Mann

Director

Thomas Carter

Director

Michael Pressman

Director

Jerry Levine

Director

John Polson