Tommy Pickles
Elizabeth Daily
Drew Pickles
Michael Bell
Didi Pickles (voice)
Melanie Chartoff
Chuckie Finster
Christine Cavanaugh
Lil Deville/Phil Deville
Kath Soucie
Angelica Pickles
Cheryl Chase
Kimi Finster (voice)
Dionne Quan
Phil/Lil
Kath Soucie*
Dil Pickles / Timmy McNulty (voice)
Tara Strong
Conductor/Wrangler/Janitor
Brian Cummings
Stu Pickles (voice)
Jack Riley
Eddie
Pat Buttram
Grandpa Lou Pickles
David Doyle
Grandpa Lou Pickles (voice)
Joe Alaskey
Grandpa Lou
Joe Alaskey*
Dr. Homer/Mr. Tippy/Little Bottle
Danny Mann
Little Kid
Dana Hill
Himself
Chick Hearn
Kirsten
Jackie Gonneau
Susie Carmichael (voice)
Cree Summer
Larry/Steve
Scott Menville
Dad/Dr. Lepetomaine/Adman 1
Dan Gilvezan
Hank
Jeremy Piven
Mabel
Linda Gary
Pamela
Tami Holbrook
Reptar/Jingle Singer
Mark Mothersbaugh
Charlotte Pickles (voice)
Tress MacNeille
Bob/Mr. Steele
Phil Proctor
Rocko Ramone
Jason Presson
Secretary/Mrs. Chesapeake
Michele Mariana
Chuckie Finster (voice)
Nancy Cartwright
Taffy
Amanda Bynes
—
Neil Ross
—
Hadley Kay
—
Tony Jay
—
Ron Glass