Tommy Pickles
Elizabeth Daily
Drew Pickles
Michael Bell
Didi Pickles (voice)
Melanie Chartoff
Chuckie Finster
Christine Cavanaugh
Phil DeVille / Lil DeVille (voice)
Kath Soucie
Angelica Pickles (voice)
Cheryl Chase
Kimi Finster (voice)
Dionne Quan
Phil/Lil
Kath Soucie*
Dil Pickles / Timmy McNulty (voice)
Tara Strong
Stu Pickles (voice)
Jack Riley
Melinda Finster
Kim Cattrall
Grandpa Lou Pickles (voice)
Joe Alaskey
Grandpa Lou
Joe Alaskey*
Captain
Vic Polizos
Lucy Carmichael
Cheryl Carter
Plumber
Andrew "Dice" Clay
Weatherman
Nathan Carlson
Grandpa Lou Pickles
David Doyle
Shlomo
Fyvush Finkel
Reptar/Knight
Jesse Corti
Susie Carmichael (voice)
Cree Summer
Howard DeVille
Phil Proctor
Jack Montello/Diner 2
Joe Mantegna
Carwash Owner/Cashier
John Byner
Joey
Benjamin Caya
Mr. Turkey
Dee Bradley Baker
Charlotte Pickles (voice)
Tress MacNeille
Sal/Vinnie
John Rubano
Frankie
Gregory Grudt
Radio Announcer/Masked Detective
Erv Immeman
Herbert
Brennan Louie
Salesman/Announcer
Sam Anderson
Dr. Brander
Laura Innes
Rabbi/Old Man
Ron Leibman
Ricky
Courtland Mead
Security
Gregg Berger
Bully
Mona Marshall
Larry
Jeremy Sisto
Story Reader
Leigh Taylor-Young
Frank/Announcer
Roger Nolan
Vinnie
Robert Costanzo
Dr. Lipschitz
Tony Jay
Lowell/Greek Bully/Donut Man
Alan Rachins
Mr. Koch/Juggler
Robert Morse
Announcer
Andre Carthen
Terry McNulty/Todd McNulty
Grey DeLisle
Sasha
Charity Sanoy
Actor/Sentry
Alan Paul
Chuckie Finster (voice)
Nancy Cartwright
Mr. Dreidel/TV Announcer
Alan Rosenberg
Tony/Diner 1
Vinny Montello
Miss Appleby
Marcia Strassman
Rob Hackett
Mark DeCarlo
Taffy
Amanda Bynes
Trash Guy/Sergeant
Kevin Michael Richardson
Lou at Age 20/Delivery Man
Scott Weil
—
Neil Ross
—
Hadley Kay
—
Scott Menville
—
Tony Jay
—
Ron Glass
—
Jeremy Piven