Tommy Pickles
Elizabeth Daily
Drew Pickles
Michael Bell
Didi Pickles (voice)
Melanie Chartoff
Chuckie Finster
Christine Cavanaugh
Phil DeVille / Lil DeVille (voice)
Kath Soucie
Angelica Pickles (voice)
Cheryl Chase
Phil/Lil
Kath Soucie*
Kimi Finster (voice)
Dionne Quan
Stu Pickles (voice)
Jack Riley
Dil Pickles / Timmy McNulty (voice)
Tara Strong
Lulu Pickles
Debbie Reynolds
Taffy
Amanda Bynes
Chuckie Finster (voice)
Nancy Cartwright
Grandpa Lou Pickles (voice)
Joe Alaskey
Grandpa Lou
Joe Alaskey*
Big Kids 1 & 2
Jennifer Hale
Lolana
Lauri Johnson
Kira Finster
Julia Kato
Susie Carmichael/Edwin Carmichael
Cree Summer
Aunt Miriam
Andrea Martin
Sheila
Diane Delano
Marvin Finster
Stacy Keach
Charlotte Pickles (voice)
Tress MacNeille
Randy Carmichael
Ron Glass
Shirley Finster
Miriam Margolyes
Howard DeVille
Phil Proctor
Dr. Cathy
Glenne Headly
Dulce/Dulce's Mother/Lloyd
Grey DeLisle
Miss Carol
Kathy Baker
Aunt T.
Irma P. Hall
Colleen McNulty
Teresa Ganzel
Tippy/Red Shirt Kid
Candi Milo
Buster Carmichael
Crystal Scales
Lucy Carmichael
Hattie Winston
Caller 1/Caller 2
Sheryl Bernstein
Emergency Announcer/Man's Voice/Plumber
David Jeremiah
Grammy Gingersnap
Bibi Osterwald
Fifi/Dog Beast
Dee Bradley Baker
Sunny
Marianne Muellerleile
Professor Spooky
Charlie Adler
Alisa Carmichael
Bettina Bush
Clown/Manager
Dai Kornberg
Cindy
Sara Gilbert
Ralph
Ryan Stiles
Marky Shark
Doug Ballard
Talent Show Director
Sean Hayes
Talent Show Host
Charlie Schlatter
Ticket Taker/Judge
David Bowe
Jumprope Friend
Becky Thyre
Young Lucy
Kimberly Brooks
Resident Woman
Jean Gillespie
Spin & Speak/Husband
Nathan Carlson
Herbert
Noelle North
Argenta
April Winchell
Emica
Adrienne Frantz
Bob-Dini
David Regal
Jonathan
Dan Castellaneta
Wife
Karen Hartman
Uncle Charles
Bill Cobbs
Cynthia P.I.
Alyson Hannigan
Miss Weemer
Vicki Lewis
Audio Mechanism
Scott Wilk
Samantha Shane
Laraine Newman
Librarian
Beverly Archer
Audience Member
Phil Reeves
—
Neil Ross
Radio Announcer
Erv Immeman
Security Guard/Harry Halibut
Rodney Saulsberry
Harold Frumpkin
Pat Musick
Miss Guppy
Monica Piper
Martin Luther King Jr.
Kevin Michael Richardson
TV Announcer
John Cramer
—
Hadley Kay
Storyteller
Ethan Phillips
—
Scott Menville
Master Wang Fong
Ping Wu
Cassie
Amber Hood
—
Tony Jay
Goddess Leader
Suzanne Kent
Steve Malone/Weatherman
Jan Rabson
Additional Voices
Sam Saletta
—
Ron Glass
—
Jeremy Piven