Jane Villanueva

Gina Rodriguez

Xiomara

Andrea Navedo

Rafael Solano

Justin Baldoni

Petra Solano/Anezka

Yael Grobglas

Michael Cordero Jr.

Brett Dier

Alba Villanueva

Ivonne Coll

Rogelio De La Vega

Jaime Camil

Chuck

Johnny Messner

Guest Star

Kelly Rutherford

Dr. Luisa Alver / Luisa Alver

Yara Martinez

Lina / Lina Santillan

Diane Guerrero

Guest Star

Yvonne Orji

Narrator (voice)

Anthony Mendez

Dina Milagro

Judy Reyes

Guest Star

Angela Oh

Guest Star

Minka Kelly

Rose Solano

Bridget Regan

Guest Star

Denise Richards

Guest Star

Alison Fernandez

Darcy Factor / Darci Factor

Justina Machado

Guest Star

Elisabeth Rohm

Guest Star

Danny Woodburn

Guest Star

Dot-Marie Jones

Guest Star

Gloria Estefan

Guest Star

Deniz Akdeniz

Esteban Santiago

Keller Wortham

Guest Star

Priscilla Barnes

Magda

Priscilla Barnes

Guest Star

Tyler Posey

Guest Star

Emilio Estefan

Guest Star

Nadine Ellis

Guest Star

Jane Seymour

Guest Star

Ricardo Chavira

Guest Star

Sofia Pernas

Fabian

Francisco San Martin

Guest Star

Jenna Ortega

Guest Star

Carmen Electra

Patricia Cordero

Molly Hagan

Marlene Donaldson

Melanie Mayron

Guest Star

Brooke Burke-Charvet

Guest Star

Jorge Diaz

Guest Star

Norma Maldonado

Guest Star

Carla Vega

Guest Star

Maya Kazan

Guest Star

Miles Gaston Villanueva

Little Girl Jane / Young Jane / 7-Year-Old Jane

Lillianna Valenzuela

Mateo Solano Villanueva

Elias Janssen

Elena Di Nola

Fabiana Udenio

Adriana Chavando

Angie Cepeda

Guest Star

Jason Huber

Guest Star

Cheryl Burke

Jorge / Jorge Garcia

Alfonso Diluca

Guest Star

Jason Sims-Prewitt

Guest Star

Mackenzie Marsh

Krishna / Krishna Dhawan

Shelly Bhalla

Guest Star

Evan Todd

Teen Xiomara

Catherine Toribio

Guest Star

Richard Shelton

Four-Year-Old Mateo

Joseph Sanders

Lieutenant Armstrong

Greg Collins

Guest Star

Alex Fernandez

Senior Network Executive

Cate Cohen

Guest Star

Mandy Levin

Guest Star

Wes Armstrong

Guest Star

Raquel Montero

Guest Star

Mia Allan

Guest Star

Francesca Santoro

Guest Star

Christopher Allen

Ellie / Ellie Solano

Ella Allan

Nadine Hansan

Azie Tesfai

Camille Collard

Production Assistant

Rudy Martinez

Jane "JR" Ramos / Jane Ramos

Rosario Dawson

Luca

Brian Dare

Susanna Barnett

Megan Ketch

Roman Zazo / Aaron Zazo

Alano Miller

Ivan

Christopher Corbin

Emilio Solano

Carlo Rota

Teenage Jane

Montse Hernandez

Frankie

Camille Collard

Lachlan Moore

Michael Rady

Jonathan Chavez

Adam Rodríguez

Derek

Mat Vairo

Young Alba

Rosie Garcia

Blanca

Greice Santo

Milos

Max Bird-Ridnell

Sonogram Technician

Vanessa Mizzone

Dana

Sheila Carrasco

Valeria

Vanessa Merrell

Victoria

Veronica Merrell-Burriss

Professor Blake

Oliver Vaquer

Sonia

Jessica Caban

Young Mateo / Mateo Sr.

Dennis Mencia

River Fields

Brooke Shields

Director

Gina Lamar

Director

Melanie Mayron

Director

Matthew Diamond

Director

Brad Silberling

Director

Fernando Sariñana

Director

Eva Longoria Baston

Director

Ricardo Chavira

Director

Anna Mastro