Jane Villanueva
Gina Rodriguez
Xiomara
Andrea Navedo
Rafael Solano
Justin Baldoni
Petra Solano/Anezka
Yael Grobglas
Michael Cordero Jr.
Brett Dier
Alba Villanueva
Ivonne Coll
Rogelio De La Vega
Jaime Camil
Chuck
Johnny Messner
Guest Star
Kelly Rutherford
Dr. Luisa Alver / Luisa Alver
Yara Martinez
Lina / Lina Santillan
Diane Guerrero
Guest Star
Yvonne Orji
Narrator (voice)
Anthony Mendez
Dina Milagro
Judy Reyes
Guest Star
Angela Oh
Guest Star
Minka Kelly
Rose Solano
Bridget Regan
Guest Star
Denise Richards
Guest Star
Alison Fernandez
Darcy Factor / Darci Factor
Justina Machado
Guest Star
Elisabeth Rohm
Guest Star
Danny Woodburn
Guest Star
Dot-Marie Jones
Guest Star
Gloria Estefan
Guest Star
Deniz Akdeniz
Esteban Santiago
Keller Wortham
Guest Star
Priscilla Barnes
Magda
Priscilla Barnes
Guest Star
Tyler Posey
Guest Star
Emilio Estefan
Guest Star
Nadine Ellis
Guest Star
Jane Seymour
Guest Star
Ricardo Chavira
Guest Star
Sofia Pernas
Fabian
Francisco San Martin
Guest Star
Jenna Ortega
Guest Star
Carmen Electra
Patricia Cordero
Molly Hagan
Marlene Donaldson
Melanie Mayron
Guest Star
Brooke Burke-Charvet
Guest Star
Jorge Diaz
Guest Star
Norma Maldonado
Guest Star
Carla Vega
Guest Star
Maya Kazan
Guest Star
Miles Gaston Villanueva
Little Girl Jane / Young Jane / 7-Year-Old Jane
Lillianna Valenzuela
Mateo Solano Villanueva
Elias Janssen
Elena Di Nola
Fabiana Udenio
Adriana Chavando
Angie Cepeda
Guest Star
Jason Huber
Guest Star
Cheryl Burke
Jorge / Jorge Garcia
Alfonso Diluca
Guest Star
Jason Sims-Prewitt
Guest Star
Mackenzie Marsh
Krishna / Krishna Dhawan
Shelly Bhalla
Guest Star
Evan Todd
Teen Xiomara
Catherine Toribio
Guest Star
Richard Shelton
Four-Year-Old Mateo
Joseph Sanders
Lieutenant Armstrong
Greg Collins
Guest Star
Alex Fernandez
Senior Network Executive
Cate Cohen
Guest Star
Mandy Levin
Guest Star
Wes Armstrong
Guest Star
Raquel Montero
Guest Star
Mia Allan
Guest Star
Francesca Santoro
Guest Star
Christopher Allen
Ellie / Ellie Solano
Ella Allan
Nadine Hansan
Azie Tesfai
Camille Collard
Production Assistant
Rudy Martinez
Jane "JR" Ramos / Jane Ramos
Rosario Dawson
Luca
Brian Dare
Susanna Barnett
Megan Ketch
Roman Zazo / Aaron Zazo
Alano Miller
Ivan
Christopher Corbin
Emilio Solano
Carlo Rota
Teenage Jane
Montse Hernandez
Frankie
Camille Collard
Lachlan Moore
Michael Rady
Jonathan Chavez
Adam Rodríguez
Derek
Mat Vairo
Young Alba
Rosie Garcia
Blanca
Greice Santo
Milos
Max Bird-Ridnell
Sonogram Technician
Vanessa Mizzone
Dana
Sheila Carrasco
Valeria
Vanessa Merrell
Victoria
Veronica Merrell-Burriss
Professor Blake
Oliver Vaquer
Sonia
Jessica Caban
Young Mateo / Mateo Sr.
Dennis Mencia
River Fields
Brooke Shields