Jane Villanueva

Gina Rodriguez

Xiomara "Xo" Villanueva

Andrea Navedo

Rafael Solano

Justin Baldoni

Petra Solano/Anezka

Yael Grobglas

Michael Cordero Jr.

Brett Dier

Alba

Ivonne Coll

Rogelio

Jaime Camil

Jane "JR" Ramos / Jane Ramos

Rosario Dawson

Adam

Tyler Posey

Jonathan Chavez

Adam Rodriguez

Katherine

Alex Meneses

Krishna / Krishna Dhawan

Shelly Bhalla

Aida

Gloria Laino

River Fields

Brooke Shields

Darcy Factor / Darci Factor

Justina Machado

Nurse

Baadja-Lyne Odums

Jorge / Jorge Garcia

Alfonso DiLuca

Lina / Lina Santillan

Diane Guerrero

Ellie / Ellie Solano

Ella Allan

Narrator (voice)

Anthony Mendez

Dr. Luisa Alver

Yara Martinez

Magda

Priscilla Barnes

Mateo Solano Villanueva

Elias Janssen

Rose Solano

Bridget Regan

Young Jane

Jenna Ortega

Anna

Mia Allan

Scott

Wes Armstrong

Nadine Hansan

Azie Tesfai

Esteban Santiago

Keller Wortham

Dennis

Christopher Allen

Frankie

Camille Collard

Director

Norma Maldonado

Production Assistant / Rudy the PA / Rudy

Rudy Martinez

Marlene Donaldson

Melanie Mayron

Teen Xiomara / Young Xo

Catherine Toribio

Luca

Brian Dare

Lieutenant Armstrong

Greg Collins

Susanna Barnett

Megan Ketch

Four-Year-Old Mateo

Joseph Sanders

Roman Zazo / Aaron Zazo

Alano Miller

Ivan

Christopher Corbin

Little Girl Jane / Young Jane / 7-Year-Old Jane

Lillianna Valenzuela

Chuck

Johnny Messner

Dina Milagro

Judy Reyes

Milos

Max Bird-Ridnell

Emilio Solano

Carlo Rota

Teenage Jane

Montse Hernandez

Bruce

Ricardo Chavira

Bobby

Tommy Dorfman

Lachlan Moore

Michael Rady

Elena Di Nola

Fabiana Udenio

Patricia Cordero

Molly Hagan

Derek

Mat Vairo

Fabian

Francisco San Martin

Young Jane / 11 Year Old Jane / 9 Year Old Jane

Cali DiCapo

Young Alba

Rosie Garcia

Blanca

Greice Santo

Sonogram Technician

Vanessa Mizzone

Senior Network Executive

Cate Cohen

Eileen

Elisabeth Röhm

Dana

Sheila Carrasco

Valeria

Vanessa Merrell

Victoria

Veronica Merrell-Burriss

Professor Blake

Oliver Vaquer

Adriana Chavando

Angie Cepeda

Jeremy Howe

Evan Todd

Sonia

Jessica Caban

Catalina

Sofia Pernas

Don Quixote Stripper / Prince Charming Stripper / Masked Figure

Joe LoCicero

Young Mateo / Mateo Sr.

Dennis Mencia

5 Year Old Jane

Julianna Gamiz