Gru

Steve Carell

Lucy Wilde

Kristen Wiig

Eduardo/El Macho

Benjamin Bratt

Margo

Miranda Cosgrove

Dr. Nefario

Russell Brand

Floyd Eagle-san (voice)

Ken Jeong

Silas

Steve Coogan

Agnes

Elsie Fisher

Edith (voice)

Dana Gaier

Antonio

Moises Arias

Jillian

Nasim Pedrad

Shannon (voice)

Kristen Schaal

Kevin the Minio/Bob the Minion/Stuart the Minion

Pierre Coffin

Additional Minions / Evil Minions / Italian Waiter (voice)

Chris Renaud

Arctic Lab Guards (voice)

Nickolai Stoilov

Flight Attendant (voice)

Vanessa Bayer

Sarah Kunze

Sonya Kraus

Additional Voices (voice)

Ava Acres

Additional Voices (voice)

Lori Alan

Additional Voices (voice)

Jack Angel

Additional Voices (voice)

Eva Bella

Additional Voices (voice)

Georgia Cook

Additional Voices (voice)

John Cygan

Additional Voices (voice)

Debi Derryberry

Additional Voices (voice)

Jess Harnell

Additional Voices (voice)

Danny Mann

Additional Voices (voice)

Mona Marshall

Additional Voices (voice)

Mickie McGowan

Additional Voices (voice)

Mason McNulty

Additional Voices (voice)

Alec Medlock

Additional Voices (voice)

Laraine Newman

Al Pacino

Additional Voices (voice)

Jan Rabson

Additional Voices (voice)

Andre Robinson

Additional Voices (voice)

Katie Silverman

Additional Voices (voice)

Casey Simpson

Additional Voices (voice)

Claira Nicole Titman

Additional Voices (voice)

Jim Ward

Additional Voices (voice)

April Winchell

Director

Chris Renaud

Director

Pierre Coffin