Gru (voice)

Steve Carell

Gru

Florentino Fernández

Vector

Jason Segel

Margo

Ana de Armas

Dr. Nefario

Russell Brand

Agnes

María Peinado

Margo (voice)

Miranda Cosgrove

Gru's Mom

Julie Andrews

Edith

Andrea Rius

Mr. Perkins

Will Arnett

Vector

Luis Posada

Agnes (voice)

Elsie Fisher

Miss Hattie

Kristen Wiig

Edith (voice)

Dana Gaier

Dr. Nefario

Lorenzo Beteta

Tim/Bob/Mark/Phil/Stuart the Minions

Pierre Coffin

Dave the Minion

Chris Renaud

Jerry the Minion

Jemaine Clement

Carnival Barker / Tourist Dad (voice)

Jack McBrayer

Fred McDade (voice)

Danny McBride

Tourist Mom (voice)

Mindy Kaling

Anchorman (voice)

Rob Huebel

Egyptian Guard (voice)

Ken Daurio

Talk Show Host (voice)

Ken Jeong

Additional Voices (voice)

Charles Bright

Additional Voices (voice)

Katie Leigh

Additional Voices (voice)

Ranjani Brow

Additional Voices (voice)

Scott Menville

Additional Voices (voice)

Holly Dorff

Additional Voices (voice)

Edie Mirman

Additional Voices (voice)

Jackie Gonneau

Additional Voices (voice)

Al Rodrigo

Additional Voices (voice)

Wendy Hoffman

Additional Voices (voice)

Jakob Roston

Additional Voices (voice)

James Kyson

Additional Voices (voice)

John Hans Tester

Additional Voices (voice)

Tony Lee

Additional Voices (voice)

Debi Mae West