Charlie Harper

Charlie Sheen

Alan Harper

Jon Cryer

Jake Harper

Angus T. Jones

Berta

Conchata Ferrell

Judith Harper

Marin Hinkle

Evelyn Harper

Holland Taylor

Russell

Martin Mull

Marty Pepper

Carl Reiner

Father Shaunassey

Dakin Matthews

Rose

Melanie Lynskey

Jill

Nadia Bjorlin

Shauna

Krista Kalmus

Melissa

Kelly Stables

Herb / Dr. Melnick

Ryan Stiles

Lyndsey Mackelroy

Courtney Thorne-Smith

Michelle

Liz Vassey

Dr. Schenkman

Steve Hytner

Gordon / Ted

J.D. Walsh

Megan

Macey Cruthird

Wanda

Anna Easteden

Esmerelda

Tonita Castro

Walden Schmidt

Ashton Kutcher

Freddy The Minister

Tom Virtue

Terry

J.J. Snyder

Gretchen

Erinn Hayes

Eldridge Mackelroy

Graham Patrick Martin

Barista

Jeff Staron

Courtney

Jenny McCarthy

Dr. Linda Freeman

Jane Lynch

Cashier

Jim Grollman

James

Jamal Duff

Overweight Woman

Debra D. Holt

Kendra

Sara Sanderson

Hot Girl in Cafe

Kelly-Ann Tursi

Tiffany

Amanda Gallo

Joanne

Caitlin Elizabeth Baunoch

Chris Mackelroy

Judd Nelson

Veronica

Desi Lydic

Little Person

Joseph Griffo

Joanne

Cait Baunoch

Locksmith

Rodney J. Hobbs

Soccer Announcer

Brian George

Chelsea / Suzanne / Tina

Jennifer Taylor

Chinese Man

Jim Lau

Tracy

Valery Ortiz

Silent Betty

Katrina Nelson

Larry

Jesse Mackey

Jim

Jim Marshall

Gang Banger

Joey Gaytan

Jenny

Amber Tamblyn

Beautiful Woman

Amelia Brantley

Zoey

Sophie Winkleman

Bridget Schmidt / Myra / Danny

Judy Greer

Mia

Emmanuelle Vaugier

TV Announcer (voice) / Announcer / Pilot (voice)

Robert Clotworthy

Larry

D. B. Sweeney

Ms. McMartin

Maggie Lawson

Kate / Robin

Brooke D'Orsay

Leanne

Rebecca McFarland

Barry

Clark Duke

Stephan 'Bobby' Wasserstein

James Edson

Robin Schmidt

Mimi Rogers

Gretchen

Kimberly Williams-Paisley

Teddy

Robert Wagner

Linda

Ming-Na Wen

Billy Stanhope

Patton Oswalt

Brooke

Aly Michalka

Joanne

Cait Fairbanks*

Nick / Petey / Doug

Joel Murray

Ava

Talyan Wright

Director

Jeff Melman

Director

Gary Halvorson

Director

Ted Wass

Director

Lee Aronsohn

Director

James Widdoes

Director

Chuck Lorre

Director

Pamela Fryman