Charlie Harper
Charlie Sheen
Alan Harper
Jon Cryer
Jake Harper
Angus T. Jones
Berta
Conchata Ferrell
Judith Harper
Marin Hinkle
Evelyn Harper
Holland Taylor
Russell
Martin Mull
Marty Pepper
Carl Reiner
Father Shaunassey
Dakin Matthews
Rose
Melanie Lynskey
Jill
Nadia Bjorlin
Shauna
Krista Kalmus
Melissa
Kelly Stables
Herb / Dr. Melnick
Ryan Stiles
Lyndsey Mackelroy
Courtney Thorne-Smith
Michelle
Liz Vassey
Dr. Schenkman
Steve Hytner
Gordon / Ted
J.D. Walsh
Megan
Macey Cruthird
Wanda
Anna Easteden
Esmerelda
Tonita Castro
Walden Schmidt
Ashton Kutcher
Freddy The Minister
Tom Virtue
Terry
J.J. Snyder
Gretchen
Erinn Hayes
Eldridge Mackelroy
Graham Patrick Martin
Barista
Jeff Staron
Courtney
Jenny McCarthy
Dr. Linda Freeman
Jane Lynch
Cashier
Jim Grollman
James
Jamal Duff
Overweight Woman
Debra D. Holt
Kendra
Sara Sanderson
Hot Girl in Cafe
Kelly-Ann Tursi
Tiffany
Amanda Gallo
Joanne
Caitlin Elizabeth Baunoch
Chris Mackelroy
Judd Nelson
Veronica
Desi Lydic
Little Person
Joseph Griffo
Joanne
Cait Baunoch
Locksmith
Rodney J. Hobbs
Soccer Announcer
Brian George
Chelsea / Suzanne / Tina
Jennifer Taylor
Chinese Man
Jim Lau
Tracy
Valery Ortiz
Silent Betty
Katrina Nelson
Larry
Jesse Mackey
Jim
Jim Marshall
Gang Banger
Joey Gaytan
Jenny
Amber Tamblyn
Beautiful Woman
Amelia Brantley
Zoey
Sophie Winkleman
Bridget Schmidt / Myra / Danny
Judy Greer
Mia
Emmanuelle Vaugier
TV Announcer (voice) / Announcer / Pilot (voice)
Robert Clotworthy
Larry
D. B. Sweeney
Ms. McMartin
Maggie Lawson
Kate / Robin
Brooke D'Orsay
Leanne
Rebecca McFarland
Barry
Clark Duke
Stephan 'Bobby' Wasserstein
James Edson
Robin Schmidt
Mimi Rogers
Gretchen
Kimberly Williams-Paisley
Teddy
Robert Wagner
Linda
Ming-Na Wen
Billy Stanhope
Patton Oswalt
Brooke
Aly Michalka
Joanne
Cait Fairbanks*
Nick / Petey / Doug
Joel Murray
Ava
Talyan Wright