Vanya Hargreeves / Number Seven / Viktor Hargreeves
Elliot Page
Luther Hargreeves / Number One
Tom Hopper
Number Five
Aidan Gallagher
Diego Hargreeves / Number Two
David Castañeda
Allison Hargreeves / Number Three
Emmy Raver-Lampman
Klaus Hargreeves / Number Four
Robert Sheehan
Ben Hargreeves / Number Six
Justin H. Min
Lila Pitts
Ritu Arya
Sir Reginald Hargreeves
Colm Feore
Dr. Gene Thibedeau
Nick Offerman
Dr. Jean Thibedeau
Megan Mullally
Grace
Jordan Claire Robbins
Sy Grossman
David Cross
Pogo (voice)
Adam Godley
The Handler
Kate Walsh
Raymond Chestnut
Yusuf Gatewood
Hazel
Cameron Britton
Agnes
Sheila McCarthy
Sissy Cooper
Marin Ireland
Herb / Pogo Body
Ken Hall
Cha-Cha
Mary J. Blige
Sloane Hargreeves
Génesis Rodríguez
Leonard Peabody
John Magaro
Axel
Kristen Holden-Ried
Otto
Jason Bryden
Young Allison
Eden Cupid
Young Luther
Cameron Brodeur
Young Klaus
Dante Albidone
Young Vanya
T.J. McGibbon
Carl Cooper
Stephen Bogaert
Chet Rodo
Julian Richings
Young Ben
Ethan Hwang*
Young Diego
Blake Talabis
Dot
Patrice Goodman
Elliot
Kevin Rankin
Fei Hargreeves
Britne Oldford
Stan
Javon Walton
Detective Chuck Beaman
Rainbow Sun Francks
Older Five / Super Old Five / Middle Aged 5
Sean Sullivan
Oscar
Tom Sinclair
Keechie
Dov Tiefenbach
Lester Pocket
Callum Keith Rennie
Abigail Hargreeves
Liisa Repo-Martell
Claire Hargreeves
Millie Davis
Young Vanya (Age 4)
Alyssa Gervasi
Detective Eudora Patch
Ashley Madekwe
Jack Ruby
John Kapelos
Young Dave
Calem MacDonald
Gruff Manager
Tony Marra
Alphonso Hargreeves
Jake Epstein
Jayme Hargreeves
Cazzie David
Wife / Lila's Mom
Shiva Safari
Jennifer
Victoria Marie