Vanya Hargreeves / Number Seven / Viktor Hargreeves

Elliot Page

Luther Hargreeves / Number One

Tom Hopper

Number Five

Aidan Gallagher

Diego Hargreeves / Number Two

David Castañeda

Allison Hargreeves / Number Three

Emmy Raver-Lampman

Klaus Hargreeves / Number Four

Robert Sheehan

Ben Hargreeves / Number Six

Justin H. Min

Lila Pitts

Ritu Arya

Sir Reginald Hargreeves

Colm Feore

Dr. Gene Thibedeau

Nick Offerman

Dr. Jean Thibedeau

Megan Mullally

Grace

Jordan Claire Robbins

Sy Grossman

David Cross

Pogo (voice)

Adam Godley

The Handler

Kate Walsh

Raymond Chestnut

Yusuf Gatewood

Hazel

Cameron Britton

Agnes

Sheila McCarthy

Sissy Cooper

Marin Ireland

Herb / Pogo Body

Ken Hall

Cha-Cha

Mary J. Blige

Sloane Hargreeves

Génesis Rodríguez

Leonard Peabody

John Magaro

Axel

Kristen Holden-Ried

Otto

Jason Bryden

Young Allison

Eden Cupid

Young Luther

Cameron Brodeur

Young Klaus

Dante Albidone

Young Vanya

T.J. McGibbon

Carl Cooper

Stephen Bogaert

Chet Rodo

Julian Richings

Young Ben

Ethan Hwang*

Young Diego

Blake Talabis

Dot

Patrice Goodman

Elliot

Kevin Rankin

Fei Hargreeves

Britne Oldford

Stan

Javon Walton

Detective Chuck Beaman

Rainbow Sun Francks

Older Five / Super Old Five / Middle Aged 5

Sean Sullivan

Oscar

Tom Sinclair

Keechie

Dov Tiefenbach

Lester Pocket

Callum Keith Rennie

Abigail Hargreeves

Liisa Repo-Martell

Claire Hargreeves

Millie Davis

Young Vanya (Age 4)

Alyssa Gervasi

Detective Eudora Patch

Ashley Madekwe

Jack Ruby

John Kapelos

Young Dave

Calem MacDonald

Gruff Manager

Tony Marra

Alphonso Hargreeves

Jake Epstein

Jayme Hargreeves

Cazzie David

Wife / Lila's Mom

Shiva Safari

Jennifer

Victoria Marie

Director

Sylvain White

Director

Stephen Surjik

Director

Jeremy Webb

Director

Ellen Kuras

Director

Paco Cabezas