Vanya

Ellen Page

Number Five

Aidan Gallagher

Luther

Tom Hopper

Hazel

Cameron Britton

Young Allison

Eden Cupid

Diego Hargreeves / Number Two

David Castañeda

Allison

Emmy Raver-Lampman

Young Luther

Cameron Brodeur

Young Ben

Ethan Hwang

Klaus

Robert Sheehan

Ben Hargreeves

Justin H. Min

Sir Reginald Hargreeves

Colm Feore

The Handler

Kate Walsh

Lila Pitts

Ritu Arya

Pogo (voice)

Adam Godley

Young Vanya

T.J. McGibbon

Grace

Jordan Claire Robbins

Raymond Chestnut

Yusuf Gatewood

Sissy

Marin Ireland

Cha-Cha

Mary J. Blige

Syd

Murray Furrow

Agnes

Sheila McCarthy

Detective Eudora Patch

Ashley Madekwe

Leonard Peabody

John Magaro

Herb / Pogo Body

Ken Hall

Sloane Hargreeves

Genesis Rodriguez

Harlan

Justin Paul Kelly

Axel

Kristen Holden-Ried

Otto

Jason Bryden

Young Klaus

Dante Albidone

Carl Cooper

Stephen Bogaert

Chet Rodo

Julian Richings

Young Diego

Blake Talabis

Dot

Patrice Goodman

Elliot

Kevin Rankin

Fei Hargreeves

Britne Oldford

Stan

Javon Walton

Detective Chuck Beaman

Rainbow Sun Francks

Super Old Five / Older Five / Old Man Five

Sean Sullivan

Oscar

Tom Sinclair

Keechie

Dov Tiefenbach

Lester Pocket

Callum Keith Rennie

Abigail Hargreeves

Liisa Repo-Martell

Dr. Gene Thibedeau

Nick Offerman

Dr. Jean Thibedeau

Megan Mullally

Claire Hargreeves

Millie Davis

Young Vanya (Age 4)

Alyssa Gervasi

Jack Ruby

John Kapelos

Young Dave

Calem MacDonald

Gruff Manager

Tony Marra

Alphonso Hargreeves

Jake Epstein

Jayme Hargreeves

Cazzie David

Wife / Lila's Mom

Shiva Safari

Jennifer

Victoria Sawal