Vanya

Ellen Page

Number Five

Aidan Gallagher

Luther Hargreeves / Number One

Tom Hopper

Hazel

Cameron Britton

Young Allison

Eden Cupid

Diego

David Castañeda

Allison Hargreeves / Number Three

Emmy Raver-Lampman

Young Luther

Cameron Brodeur

Young Ben

Ethan Hwang*

Klaus

Robert Sheehan

Ben Hargreeves

Justin H. Min

Sir Reginald Hargreeves

Colm Feore

The Handler

Kate Walsh

Pogo

Adam Godley

Grace

Jordan Claire Robbins

Lila Pitts

Ritu Arya

Young Vanya

T.J. McGibbon

Raymond Chestnut

Yusuf Gatewood

Sissy

Marin Ireland

Cha-Cha

Mary J. Blige

Syd

Murray Furrow

Agnes

Sheila McCarthy

Detective Eudora Patch

Ashley Madekwe

Leonard Peabody

John Magaro

Sloane Hargreeves

Génesis Rodríguez

Herb / Pogo Body

Ken Hall

Axel

Kristen Holden-Ried

Otto

Jason Bryden

Carl Cooper

Stephen Bogaert

Chet Rodo

Julian Richings

Young Klaus / Teen Klaus

Dante Albidone

Elliot

Kevin Rankin

Fei Hargreeves

Britne Oldford

Stan

Javon Walton

Detective Chuck Beaman

Rainbow Sun Francks

Young Diego

Blake Talabis

Older Five / Super Old Five / Middle Aged 5

Sean Sullivan

Keechie

Dov Tiefenbach

Dot

Patrice Goodman

Lester Pocket

Callum Keith Rennie

Young Vanya (Age 4)

Alyssa Gervasi

Oscar

Tom Sinclair

Jack Ruby

John Kapelos

Young Dave

Calem MacDonald

Gruff Manager

Tony Marra

Jayme Hargreeves / Jayme

Cazzie David

Alphonso Hargreeves

Jake Epstein

Director

Andrew Bernstein

Director

Peter Hoar

Director

Stephen Surjik

Director

Jeremy Webb

Director

Ellen Kuras

Director

Paco Cabezas