Vanya
Ellen Page
Luther Hargreeves / Number One
Tom Hopper
Allison Hargreeves / Number Three
Emmy Raver-Lampman
Cha-Cha
Mary J. Blige
Number Five
Aidan Gallagher
Diego
David Castaneda
Hazel
Cameron Britton
Klaus Hargreeves / Number Four
Robert Sheehan
Pogo
Adam Godley
Detective Eudora Patch
Ashley Madekwe
Ben Hargreeves / Number Six
Justin H. Min
Sir Reginald Hargreeves
Colm Feore
Grace
Jordan Claire Robbins
Lila Pitts
Ritu Arya
Leonard Peabody
John Magaro
Young Allison
Eden Cupid
The Handler
Kate Walsh
Young Luther
Cameron Brodeur
Raymond Chestnut
Yusuf Gatewood
Young Ben
Ethan Hwang*
Agnes
Sheila McCarthy
Young Vanya
T.J. McGibbon
Syd
Murray Furrow
Sissy
Marin Ireland
Sloane Hargreeves
Génesis Rodríguez
Herb / Pogo Body
Ken Hall
Axel
Kristen Holden-Ried
Otto
Jason Bryden
Carl Cooper
Stephen Bogaert
Chet Rodo
Julian Richings
Young Klaus / Teen Klaus
Dante Albidone
Elliot
Kevin Rankin
Fei Hargreeves
Britne Oldford
Stan
Javon Walton
Detective Chuck Beaman
Rainbow Sun Francks
Young Diego
Blake Talabis
Older Five / Super Old Five / Middle Aged 5
Sean Sullivan
Keechie
Dov Tiefenbach
Dot
Patrice Goodman
Lester Pocket
Callum Keith Rennie
Young Vanya (Age 4)
Alyssa Gervasi
Oscar
Tom Sinclair
Jack Ruby
John Kapelos
Young Dave
Calem MacDonald
Gruff Manager
Tony Marra
Jayme Hargreeves / Jayme
Cazzie David
Alphonso Hargreeves
Jake Epstein