Stan Smith/Roger

Seth MacFarlane

Francine Smith

Wendy Schaal

Hayley Smith

Rachael MacFarlane

Steve Smith

Scott Grimes

Klaus

Dee Bradley Baker

Hiko Yoshida (voice) / Katie (voice)

Sandra Oh

Ashley

Hayden Panettiere

Himself/Concierge

Héctor Elizondo

Sal

Jason Alexander

Jeff Fischer (voice) / Kidnapper (voice) / Donnie Patterson (voice)

Jeff Fischer

Rusty

Lou Diamond Phillips

Snot Lonstein (voice) / Snot Lonstein / Eli Weisel (voice)

Curtis Armstrong

Cam

Sarah Chalke

Sen. Buckingham

Burt Reynolds

Terry Bates (voice) / (voice) / Sanders (voice)

Mike Barker

Charlie Greenfield (voice) / Butt Insurance Salesman (voice) / Security Guard (voice)

Will Forte

Guest Voice

Jana Levenstein

Avery Bullock (voice) / Avery Bullock as B (voice) / Avery Bullock Sr. (voice)

Patrick Stewart

Bob Todd

Eric Durbin

Sharri Rothberg (voice)

Lisa Edelstein

Tom

Anthony Michael Hall

(voice) / Michelle (voice) / Woman (voice)

Paget Brewster

Toshi

Daisuke Suzuki

(voice) / Hooper (voice) / Alien (voice)

Alex Cuthbertson

Duper (voice)

Phill Lewis

Vince Chung (voice)

John Cho

Guest Voice

Rick Podell

Female Juror

Kat Dennings

(voice) / Dalai Lama (voice) / Stan's New Voice (voice)

Chris Diamantopoulos

Grandpa Smith

Ed Asner

Liquor Store Manager

Clancy Brown

Bah Bah (voice)

Tzi Ma

Guest Voice

Roberto Gomez

Mailbox 1

Carl Reiner

Father Donovan (voice)

Martin Mull

Birth Show Narrator

Alice Evans

Guest Voice

Missi Pyle

Guest Voice

Terry Crews

(voice) / Kidnapper (voice) / CIA Guy (voice)

Jonathan Fener

Sooleawa'uha

Tonantzin Carmelo

Buckle (voice) / (voice) / Santa Claus (voice)

Matt McKenna*

Principal Lewis (voice) / Billy (voice) / Principal Lewis

Kevin Michael Richardson

Jackson (voice) / Jackson / Charlie (voice)

Mike Henry

Guest Voice

Beth Grant

Lessie

Jenifer Lewis

Guest Voice

Danny Cistone

Guest Voice

Chad Brannon

Juror

Zach Galifianakis

Colby (voice) / (voice) / Scientist (voice)

Amir Talai

(voice) / Reginald (voice) / Crisp's Henchman (voice)

Erik Durbin

Guest Voice

Elmarie Wendel

Guest Voice

Erik Sommers

Talking Cabbage

H. Jon Benjamin

Mah Mah (voice) / Mah Mah Ling / Helen (voice)

Amy Hill

Betty Smith (voice) / Marylin Thacker (voice)

Swoosie Kurtz

Qui Lo

Don Tai

Dr. Weitzman (voice) / (voice) / Alien (voice)

Matt E. Mixer

Barry Robinson (voice) / Barry Robinson / Spike (voice)

Eddie Kaye Thomas

Guest Voice

Roger Fan

(voice) / Kid with Adult Voice (voice) / Announcer (voice)

Maurice LaMarche

Naydern

Christina Hendricks

Massage Therapist/Gang Leader

Masasa Moyo

Guest Voice

Craig Gass

Butch Johnson

Ken Jeong

Andy Dick (voice) / Costgo Employee (voice) / (voice)

Nick Kroll

Guest Voice

J.K. Simmons

Dick Reynolds (voice) / Dick (voice) / Wilbur Kentucky (voice)

David Koechner

Dr. Kalgary (voice) / (voice) / Dr. Kalgary

Alan Tudyk

Airport Security Guard

J.B. Smoove

Stacy

Lucy Lawless

Monster Hunter

Ron Perlman

Guest Voice

Anna Maria Horsford

(voice) / Student (voice) / Various (voice)

Matt Fusfeld

Guest Voice

Richard Gant

Lorraine (voice) / Angel (voice) / Patty LaBelle (voice)

Niecy Nash

Guest Voice

Nahnatchka Khan

Cookie

Azura Skye

Ray (voice)

Victor Raider-Wexler

Lisa Silver

Leisha Hailey

(voice) / Mertz (voice) / Townsperson (voice)

Judah Miller

Guest Voice

Scott Mosenson

Guest Voice

Peter Paige

Al Tuttle (voice) / Car Salesman (voice)

Richard Kind

John Q. Mind

Randy Spears

(voice) / Additional Voices (voice) / Anti-Christ (voice)

Murray Miller

Akiko Yoshida

Grace Park

Greg Corbin

Hayley Smith

Klaus

Esther Lonstein (voice) / Danuta (voice) / Diner Patron (voice)

Nicole Shabtai

Memphis Stormfront (voice) / Bar Bro (voice) / Waiter (voice)

Andy Daly

Terry Bates

Kashi (voice) / (voice) / Mailman (voice)

Nic Wegener

Parker (voice) / (voice) / Student (voice)

Parker Deay

(voice) / Secret Service Agent (voice) / ER Doctor (voice)

Fred Tatasciore

James Garfield (voice) / Co-Worker (voice) / (voice)

Chris Parnell

(voice) / Wife (voice) / Sewer Woman (voice)

Jill Talley

Mike Baker

Suze (voice) / Wife (voice) / Hannah (voice)

June Diane Raphael

Police Officer (voice) / Officer Blatt (voice) / Zach

David Herman