Stan Smith/Roger

Seth MacFarlane

Hayley Smith (voice)

Rachael MacFarlane

Francine Smith

Wendy Schaal

Steve Smith

Scott Grimes

Klaus (voice)

Dee Bradley Baker

(voice) / Various (voice) / Jeremy (voice)

Joe Chandler

Dr. Revanche

Simon Helberg

Memphis Stormfront (voice) / Bar Bro (voice) / Waiter (voice)

Andy Daly

Agatha / Old Woman / Receptionist

Kimberly Brooks

Mr. Orlando

Jason Alexander

(voice) / Dalai Lama (voice) / Stan's New Voice (voice)

Chris Diamantopoulos

Avery Bullock (voice) / Avery Bullock as B (voice) / Avery Bullock Sr. (voice)

Patrick Stewart

Jackson (voice) / Jackson / Charlie (voice)

Mike Henry

Huell Howser (voice) / Lorne Mikeys (voice) / The Falcon (voice)

James Adomian

Mr. Makahama

Yoshi Ando

Audience Member

Sarah Adina

Snot Lonstein (voice) / Snot Lonstein / Eli Weisel (voice)

Curtis Armstrong

Agent Wolfman

Rene Gube

(voice) / Michelle (voice) / Woman (voice)

Paget Brewster

Stiles (voice) / Black Steve #1 / Black Steve #2 (voice)

Brandon Black

Kite Kid

Luke Lowe

Professor

Taliesin Jaffe

Nerfer

Rachel Dratch

Mother (voice) / Al (voice) / Timmy's Mom (voice)

Jane Lynch

Jeff Fischer (voice) / Kidnapper (voice) / Donnie Patterson (voice)

Jeff Fischer

Fake Francine

Deanne Jacobs

Buckle (voice) / (voice) / Santa Claus (voice)

Matt McKenna*

Agent Cara

Eliza Coupe

Principal Lewis (voice) / Billy (voice) / Principal Lewis

Kevin Michael Richardson

Police Officer (voice) / Officer Blatt (voice) / Zach

David Herman

Al Tuttle (voice) / Car Salesman (voice)

Richard Kind

Gross Oyster Man (voice) / Gary Gogo (voice) / Chicago Dave (voice)

Jon Daly

Assistant (voice) / Exterminator (voice) / Fox (voice)

Phil LaMarr

Toad Button

Pete Davidson

Dr. Weitzman (voice) / (voice) / Alien (voice)

Matt E. Mixer

Billy Boyd

Kyle McCarley

Roger's Fan

Patti Harrison

Chinchilla Slim

Cree Summer

Dick Reynolds (voice) / Dick (voice) / Wilbur Kentucky (voice)

David Koechner

(voice) / Candy Maker (voice) / Cinema Ticket Man (voice)

Patton Oswalt

Jacked Convict

Matthew Gudernatch

Fire Captain

Keith David

Prom Girl (voice) / Woman Carrying Dog (voice) / Stunning Woman

Courtenay Taylor

Miss Macadoo

Ann Dowd

Tom (voice) / (voice) / Rogu (voice)

Josh Fadem

Sky Crooner (voice) / Groom (voice)

Tommy Blacha

Lexie

Alyson Hannigan

Wild Willie

Breckin Meyer

Doctor

Paul W. Downs

Ron Perlman

Craig Robinson (voice) / (voice) / MC Avalanche (voice)

Craig Robinson

Barry Robinson (voice) / Barry Robinson / Spike (voice)

Eddie Kaye Thomas

Criss Angel

Terry Bates (voice) / (voice) / Sanders (voice)

Mike Barker

Bill Nye

Toshi Yoshida (voice)

Daisuke Suzuki

(voice) / Mertz (voice) / Townsperson (voice)

Judah Miller

(voice) / Hooper (voice) / Alien (voice)

Alex Cuthbertson

Esther Lonstein (voice) / Danuta (voice) / Diner Patron (voice)

Nicole Shabtai

Dr. Kalgary (voice) / (voice) / Dr. Kalgary

Alan Tudyk

Kashi (voice) / (voice) / Mailman (voice)

Nic Wegener

Parker (voice) / (voice) / Student (voice)

Parker Deay

(voice) / Secret Service Agent (voice) / ER Doctor (voice)

Fred Tatasciore

(voice) / Reginald (voice) / Crisp's Henchman (voice)

Erik Durbin

James Garfield (voice) / Co-Worker (voice) / (voice)

Chris Parnell

(voice) / Wife (voice) / Sewer Woman (voice)

Jill Talley

Suze (voice) / Wife (voice) / Hannah (voice)

June Diane Raphael

Jack Smith (voice) / Trailer Narrator (voice) / Guinness Official (voice)

Daran Norris

(voice) / Jerry Seinfeld (voice) / Junior (voice)

Josh Robert Thompson

(voice) / Kidnapper (voice) / CIA Guy (voice)

Jonathan Fener

Trish (voice) / Italian Woman (voice) / Trish

Casey Wilson

DelMonaco (voice) / Jake (voice) / Chef (voice)

Andy Richter

Raymond (voice) / Satan (voice) / (voice)

Thomas Lennon

Construction Worker (voice) / Carl (voice) / Werb-Berg the Woobler (voice)

John DiMaggio

(voice) / Mobster (voice) / Leonard Zane (voice)

André Sogliuzzo

(voice) / Kid with Adult Voice (voice) / Announcer (voice)

Maurice LaMarche

(voice) / Student (voice) / Various (voice)

Matt Fusfeld

(voice) / Additional Voices (voice) / Anti-Christ (voice)

Murray Miller

Colby (voice) / (voice) / Scientist (voice)

Amir Talai

Security Guard (voice) / (voice) / Prisoner (voice)

Gary Anthony Williams

(voice) / Dawson Family Member (voice) / Successful Classmate (voice)

Brian Boyle

Big Ed (voice) / Freddy Underwood (voice) / Lindsey (voice)

Khary Payton

Donald Magillicutty (voice) / Eric Jermesian III (voice) / Mr. Rick (voice)

Tom Kenny

(voice) / Student (voice) / Townsperson (voice)

Jeff Kauffmann

Betty Smith (voice) / Marylin Thacker (voice)

Swoosie Kurtz

Duper (voice)

Phill Lewis

Father Donovan (voice)

Martin Mull

Chief Shopaholic / Midnight Runner #1 / Salesman (voice)

Peter MacKenzie

(voice) / Ugly Stepsister #3 (voice) / Assistant (voice)

Marissa Jaret Winokur

Freddy (voice) / Pete Krachowski (voice) / Tommy (voice)

Joe Lo Truglio

Working Class Brit (voice) / Mr. Collins / Sherlock Holmes (voice)

Tom Hollander

(voice)

Erik Sommers

Mah Mah (voice) / Mah Mah Ling / Helen (voice)

Amy Hill

Charlie Greenfield (voice) / Butt Insurance Salesman (voice) / Security Guard (voice)

Will Forte

Zookeeper (voice) / Lonnie Bolmenferg (voice) / (voice)

Eric Edelstein

(voice) / Fruit Cart Man (voice) / Javier (voice)

Ignacio Serricchio

Officer Caruso (voice) / Police Officer (voice) / Pawn Shop Owner (voice)

Bashir Salahuddin

Dick (voice) / Dick / Dentist's Father (voice)

Stephen Root

Esther Lonstein (voice)

Susie Essman

Police Officer (voice) / Harvey Lissel (voice) / Coach Melonis (voice)

Rob Riggle