Stan Smith / Roger (voice)

Seth MacFarlane

Francine Smith

Wendy Schaal

Hayley Smith (voice)

Rachael MacFarlane

Steve Smith

Scott Grimes

Klaus (voice)

Dee Bradley Baker

Old Stripper

Rhea Perlman

Terry Bates (voice) / (voice) / Sanders (voice)

Mike Barker

Himself

Jon Hamm

Gina

Michelle Monaghan

Charlie Greenfield (voice) / Butt Insurance Salesman (voice) / Security Guard (voice)

Will Forte

Avery Bullock (voice) / Avery Bullock as B (voice) / Avery Bullock Sr. (voice)

Patrick Stewart

Principal Lewis (voice) / Billy (voice) / Principal Lewis

Kevin Michael Richardson

Jenny

Sarah Michelle Gellar

American Businessman Klaus

Nathan Fillion

Assistant (voice) / Exterminator (voice) / Fox (voice)

Phil LaMarr

Esther Lonstein (voice)

Susie Essman

Betty Smith (voice) / Marylin Thacker (voice)

Swoosie Kurtz

Cuba Gooding Jr. (voice) / Major (voice) / Wayne Brady (voice)

Wayne Brady

Jack Smith (voice) / Trailer Narrator (voice) / Guinness Official (voice)

Daran Norris

Steve

Ricky Blitt

Gina's Replacement Waitress

Mariah Carey

(voice) / Kidnapper (voice) / CIA Guy (voice)

Jonathan Fener

Jeff Fischer (voice) / Kidnapper (voice) / Donnie Patterson (voice)

Jeff Fischer

Luis

John Leguizamo

Guest Voice

Kathy Griffin

Emperor Zing

Michael McKean

Lindsay

Alison Brie

Noah's Father / Lifeguard (voice) / Taco King Spokesman (voice)

Kasey Bell

Snot Lonstein (voice) / Snot Lonstein / Eli Weisel (voice)

Curtis Armstrong

Mah Mah (voice) / Mah Mah Ling / Helen (voice)

Amy Hill

(voice) / Dawson Family Member (voice) / Successful Classmate (voice)

Brian Boyle

Woman

Yana Galuz

Foster

Sean Hayes

Father Donovan (voice)

Martin Mull

Jon

Charlie Day

Guest Voice

Ari Graynor

Guest Voice

Laura McCreary

(voice) / Dalai Lama (voice) / Stan's New Voice (voice)

Chris Diamantopoulos

Rita Rudner

Jill Bartlett

Brenda Calhoun

Hali Lula Hudson

Peasant Daughter

Alyson Hannigan

Craig

Morris Chestnut

Bah Bah (voice)

Tzi Ma

Dr. Weitzman (voice) / (voice) / Alien (voice)

Matt E. Mixer

(voice) / Hooper (voice) / Alien (voice)

Alex Cuthbertson

Shonteeva's Assistant

Jackée Harry

Himself

Sinbad

Dick Reynolds (voice) / Dick (voice) / Wilbur Kentucky (voice)

David Koechner

Liam

Rupert Grint

Narrator

Michelle Dockery

Suze (voice) / Wife (voice) / Hannah (voice)

June Diane Raphael

Al Tuttle (voice) / Car Salesman (voice)

Richard Kind

(voice) / Additional Voices (voice) / Anti-Christ (voice)

Murray Miller

Hiko Yoshida (voice) / Katie (voice)

Sandra Oh

Maguerite

Michael Peña

Shonteeva

Octavia Spencer

Larry Herman

James Karen

(voice) / Fat Kid (voice) / Tyler (voice)

Eric Edwards

Guest Voice

Janelle Monáe

Himself

Jonny Moseley

Barry Robinson (voice) / Barry Robinson / Spike (voice)

Eddie Kaye Thomas

Colby (voice) / (voice) / Scientist (voice)

Amir Talai

Akiko Yoshida

Grace Park

Swinger

Eric McCormack

(voice) / Mertz (voice) / Townsperson (voice)

Judah Miller

Guest Voice

Keith Heisler

(voice) / Michelle (voice) / Woman (voice)

Paget Brewster

Dr. Kalgary (voice) / (voice) / Dr. Kalgary

Alan Tudyk

Lew Schneider

Lew Schneider

Guest Voice

Amy Sedaris

(voice) / Reginald (voice) / Crisp's Henchman (voice)

Erik Durbin

Himself

Shaun White

(voice) / Student (voice) / Various (voice)

Matt Fusfeld

Goran the Mutilator

Peter Serafinowicz

Boy (voice) / (voice) / Camper (voice)

Max Charles

Jackson (voice) / Jackson / Charlie (voice)

Mike Henry

Toshi Yoshida (voice)

Daisuke Suzuki

Guest Voice

Peter Holmes

Little Girl

Tatum Hentemann

(voice) / Wife (voice) / Sewer Woman (voice)

Jill Talley

Buckle (voice) / (voice) / Santa Claus (voice)

Matt McKenna*

Esther Lonstein (voice) / Danuta (voice) / Diner Patron (voice)

Nicole Shabtai

Memphis Stormfront (voice) / Bar Bro (voice) / Waiter (voice)

Andy Daly

Kashi (voice) / (voice) / Mailman (voice)

Nic Wegener

Parker (voice) / (voice) / Student (voice)

Parker Deay

(voice) / Secret Service Agent (voice) / ER Doctor (voice)

Fred Tatasciore

James Garfield (voice) / Co-Worker (voice) / (voice)

Chris Parnell

Police Officer (voice) / Officer Blatt (voice) / Zach

David Herman

(voice) / Jerry Seinfeld (voice) / Junior (voice)

Josh Robert Thompson

Tom (voice) / (voice) / Rogu (voice)

Josh Fadem

(voice) / Various (voice) / Jeremy (voice)

Joe Chandler

Trish (voice) / Italian Woman (voice) / Trish

Casey Wilson

DelMonaco (voice) / Jake (voice) / Chef (voice)

Andy Richter

Raymond (voice) / Satan (voice) / (voice)

Thomas Lennon

Construction Worker (voice) / Carl (voice) / Werb-Berg the Woobler (voice)

John DiMaggio

Prom Girl (voice) / Woman Carrying Dog (voice) / Stunning Woman

Courtenay Taylor

(voice) / Mobster (voice) / Leonard Zane (voice)

André Sogliuzzo

(voice) / Kid with Adult Voice (voice) / Announcer (voice)

Maurice LaMarche

Security Guard (voice) / (voice) / Prisoner (voice)

Gary Anthony Williams

Sky Crooner (voice) / Groom (voice)

Tommy Blacha