Captain Michael Burnham
Sonequa Martin-Green
Saru
Doug Jones
Paul Stamets
Anthony Rapp
Sylvia Tilly
Mary Wiseman
Dr. Hugh Culber
Wilson Cruz
Cleveland "Book" Booker
David Ajala
Adira Tal
Blu del Barrio
Lt. / Lt. Cmdr. Keyla Detmer
Emily Coutts
Lt. / Lt. Cmdr. Joann Owosekun
Oyin Oladejo
Gray Tal
Ian Alexander
Lt. / Lt. Cmdr. Gen Rhys
Patrick Kwok-Choon
Rayner
Callum Keith Rennie
Comm Officer 2 / Lt. / Lt. Cmdr. R.A. Bryce
Ronnie Rowe
Lt. / Lt. Cmdr. Nilsson / Airiam
Sara Mitich
Ash Tyler
Shazad Latif
Emperor Philippa Georgiou / Captain Philippa Georgiou
Michelle Yeoh
Discovery Computer (voice) / Sanctuary Voice (voice)
Julianne Grossman
Lt. J.G. Linus the Saurian / Young Su'Kal / Cosmo Traitt
David Benjamin Tomlinson
Fleet Admiral Charles Vance
Oded Fehr
Gabriel Lorca
Jason Isaacs
Dr. Nambue
Maulik Pancholy
Christopher Pike
Anson Mount
L'Rell
Mary Chieffo
Commander (Cmdr.) Jett Reno
Tig Notaro
Admiral Katrina Cornwell
Jayne Brook
Cmdr. Nhan
Rachael Ancheril
Lt. Cmdr. Airiam
Hannah Cheesman
Zora (voice)
Annabelle Wallis
President T'Rina
Tara Rosling
Federation President Laira Rillak
Chelah Horsdal
Kol / Invigilator Aurellio / Kol-Sha
Kenneth Mitchell
Spock / Spock (voice)
Ethan Peck
Book's Ship Computer (voice)
Fabio Tassone
Amanda Grayson
Mia Kirshner
Leland
Alan Van Sprang
Yeoman Colt / Klingon / Orion Delegate
Nicole Dickinson
Ruon Tarka
Shawn Doyle
Lt. Ina / Kelpien Council Member #2 / Captain Rahma
Avaah Blackwell
Kovich
David Cronenberg
Lt. Christopher
Orville Cummings
Young Michael Burnham
Arista Arhin
Ndoye
Phumzile Sitole
Shenzhou Computer (voice)
Tasia Valenza
Number One
Rebecca Romijn
Commander Landry
Rekha Sharma
Andorian Regulator / Admiral Shukar / Andorian Admiral
Riley Gilchrist
Lt. Audrey Willa
Vanessa Jackson
Dr. Gabrielle Burnham
Sonja Sohn
Dr. / Cmdr. Tracy Pollard
Raven Dauda