Michael Burnham
Sonequa Martin-Green
Saru
Doug Jones
Captain Lorca
Jason Isaacs
Paul Stamets
Anthony Rapp
Emperor Philippa Georgiou / Captain Philippa Georgiou
Michelle Yeoh
Sylvia Tilly
Mary Wiseman
Lt. Tyler
Shazad Latif
Dr. Hugh Culber
Wilson Cruz
Cleveland Booker
David Ajala
Lt. / Lt. Cmdr. Keyla Detmer
Emily Coutts
Gray
Ian Alexander
Lt. / Lt. Cmdr. Joann Owosekun
Oyin Oladejo
Adira
Blu del Barrio
T'Kuvma
Chris Obi
Commander (Cmdr.) Jett Reno
Tig Notaro
L'Rell
Mary Chieffo
Lt. / Lt. Cmdr. Gen Rhys
Patrick Kwok-Choon
Comm Officer 2 / Lt. / Lt. Cmdr. R.A. Bryce
Ronnie Rowe
Sarek
James Frain
Harry Mudd
Rainn Wilson
Brett Anderson
Terry Serpico
Lt. / Lt. Cmdr. Nilsson / Airiam
Sara Mitich
Dr. Nambue
Maulik Pancholy
Ujilli
Damon Runyan
Commander Landry
Rekha Sharma
Kol / Invigilator Aurellio / Kol-Sha
Kenneth Mitchell
Discovery Computer (voice) / Sanctuary Voice (voice)
Julianne Grossman
Dennas
Clare McConnell
Lt. J.G. Linus the Saurian / Young Su'Kal / Cosmo Traitt
David Benjamin Tomlinson
Ensign Connor
Sam Vartholomeos
Fleet Admiral Charles Vance
Oded Fehr
Capt. Christopher Pike
Anson Mount
Spock / Spock (voice)
Ethan Peck
Admiral Katrina Cornwell
Jayne Brook
Cmdr. Nhan
Rachael Ancheril
Lt. Cmdr. Airiam
Hannah Cheesman
Zora (voice)
Annabelle Wallis
President T'Rina
Tara Rosling
Raynor
Callum Keith Rennie
Federation President Laira Rillak
Chelah Horsdal
Book's Ship Computer (voice)
Fabio Tassone
Amanda Grayson
Mia Kirshner
Leland
Alan Van Sprang
Yeoman Colt / Klingon / Orion Delegate
Nicole Dickinson
Ruon Tarka
Shawn Doyle
Lt. Ina / Kelpien Council Member #2 / Captain Rahma
Avaah Blackwell
Kovich
David Cronenberg
Lt. Christopher
Orville Cummings
Young Michael Burnham
Arista Arhin
Ndoye
Phumzile Sitole
Shenzhou Computer (voice)
Tasia Valenza
Number One
Rebecca Romijn
Andorian Regulator / Admiral Shukar / Andorian Admiral
Riley Gilchrist
Lt. Audrey Willa
Vanessa Jackson
Dr. Gabrielle Burnham
Sonja Sohn
Dr. / Cmdr. Tracy Pollard
Raven Dauda