Lucas Scott

Chad Michael Murray

Nathan Scott

James Lafferty

Peyton Sawyer

Hilarie Burton

Haley James Scott

Bethany Joy Lenz

Dan Scott

Paul Johansson

Brooke Davis

Sophia Bush

Coach Brian "Whitey" Durham

Barry Corbin

Marvin `Mouth' McFadden

Lee Norris

Karen Roe

Moira Kelly

Keith Scott

Craig Sheffer

Deb Scott

Barbara Alyn Woods

Antwon 'Skills' Taylor

Antwon Tanner

Jamie Scott

Jackson Brundage

Millicent Huxtable

Lisa Goldstein

Guest Star

Michael Trucco

Rachel Gattina

Danneel Harris

Chris Keller

Tyler Hilton

Larry Sawyer

Kevin Kilner

Guest Star

Sheryl Lee

Guest Star

Danny Woodburn

Jake Jagielski

Bryan Greenberg

Guest Star

Colin Fickes

Guest Star

Mekia Cox

Guest Star

Joshua Snyder

Guest Star

Michelle Featherstone

Guest Star

Donna Cooper

Guest Star

Texas Battle

Guest Star

Chip Lane

Guest Star

Allison Scagliotti

Terry

Austin James Harter

Guest Star

Brett Claywell

Guest Star

Pete Wentz

Principal Turner

Shawn Shepard

Young Keith

Jackson Pearce

Julian Baker

Austin Nichols

Guest Star

Mike Harding

Guest Star

Marcus Coloma

Guest Star

Peyton List

Guest Star

Marcus Lyle Brown

Guest Star

Kelsey Chow

Guest Star

Bevin Prince

Guest Star

Brandon Wade

Guest Star

Cullen Moss

Guest Star

Jimmy Hager

Guest Star

Vaughan Wilson

Clay Evans

Robert Buckley

Quinn James

Shantel VanSanten

Chase Adams

Stephen Colletti

Alex Dupre

Jana Kramer

Victoria Davis

Daphne Zuniga

Mia Catalano

Kate Voegele

Chuck

Michael May

Lauren

Allison Munn

Jerry

Bradley Evans

Sam Walker

Ashley Rickards

Andy Hargrove

Kieren Hutchison

Lindsey Strauss

Michaela McManus

Quentin Fields

Robbie Jones

Madison

Katherine Landry

Carrie

Torrey DeVitto

Owen Morello

Joe Manganiello

Felix Taggaro

Michael Copon

Anna Taggaro

Daniella Alonso

Paul Norris

Gregory Harrison

Miranda Stone

India de Beaufort

Katie / Sara

Amanda Schull

Jules

Maria Menounos

Nicki

Emmanuelle Vaugier

Grubbs

Michael Grubbs

Alexander Coyne

Mitch Ryan

Dr. Milford

Terry Loughlin

Andre

Jaden Harmon

Taylor James

Lindsey McKeon

Bobby

Burgess Jenkins

Derek

Matt Barr

David Fletcher

Scott Holroyd

Renee

Kate French

Theresa

Sarah Edwards

Rick

William Haze

Xavier / Man

Devin McGee

Logan

Pierce Gagnon

Dr. Hudson / KiKi

Jessica Lucas

Josh

Paul Teal

Erin

Laura Izibor

Derek Sommers

Ernest Waddell

Shelley Simon

Elisabeth Harnois

Ted Davis

Richard Burgi

Billy

Manu Intiraymi

Pablo Alvarez

David Norona

Jack Daniels

Evan Peters

Mrs. Skolnick

Kelley Davis

Sylvia Baker

Sharon Lawrence

August Kellerman

Peter Riegert

Larry Sawyer

Thomas Ian Griffith

Erica Marsh

Katherine Bailess

Lydia James

Bess Armstrong

Tara Richards

Chelsea kane

Dr. Hale / Doctor

Dorothy Recasner Brown

Devon Fox / Ref

B.J. Britt

Reeves / Detective

David Bridgewater