Nathan Scott

James Lafferty

Haley James-Scott

Bethany Joy Galeotti

Brooke Davis

Sophia Bush

Mouth McFadden

Lee Norris

Julian Baker

Austin Nichols

Antwon `Skills' Taylor

Antwon Tanner

Clay Evans

Robert Buckley

Dan Scott

Paul Johansson

Quinn James

Shantel VanSanten

Lucas Scott

Chad Michael Murray

Jamie Scott

Jackson Brundage

Peyton Sawyer

Hilarie Burton Morgan

Alex Dupré

Jana Kramer

Millicent `Millie' Huxtable

Lisa Goldstein

Deb Scott

Barbara Alyn Woods

Guest Star

Mitch Ryan

Lydia James

Bess Armstrong

Katie / Sara

Amanda Schull

Guest Star

Allison Munn

Guest Star

Danneel Harris

Guest Star

Sasha Jackson

Taylor James

Lindsey McKeon

David Fletcher

Scott Holroyd

Whitey Durham

Barry Corbin

Guest Star

Kristy Swanson

Chase Adams

Stephen Colletti

Guest Star

Kate French

Guest Star

Lorna Raver

Karen Roe

Moira Kelly

Miranda Stone

India de Beaufort

Mia Catalano

Kate Voegele

Guest Star

Michael Grubbs

Guest Star

Jody Thompson

Guest Star

Michael May

Paul Norris

Gregory Harrison

Victoria Davis

Daphne Zuniga

Guest Star

Paul Teal

Keith Scott

Craig Sheffer

Fergie

Vaughn Wilson

Junk

Cullen Moss

Bevin

Bevin Prince

Tim Smith

Brett Claywell

Chris Keller

Tyler Hilton

Jake Jagielski

Bryan Greenberg

Jerry

Bradley Evans

Sam Walker

Ashley Rickards

Andy Hargrove

Kieren Hutchison

Gigi

Kelsey Asbille

Lindsey Strauss

Michaela McManus

Principal Turner

Shawn Shepard

Quentin Fields

Robbie Jones

Madison

Katherine Landry

Carrie

Torrey DeVitto

Owen Morello

Joe Manganiello

Felix Taggaro

Michael Copon

Anna Taggaro

Daniella Alonso

Jules

Maria Menounos

Nicki

Emmanuelle Vaugier

Dr. Milford

Terry Loughlin

Ellie Harp

Sheryl Lee

Andre

Jaden Harmon

Bobby

Burgess Jenkins

Derek

Matt Barr

Theresa

Sarah Edwards

Rick

William Haze

Xavier / Man

Devin McGee

Logan

Pierce Gagnon

Dr. Hudson / KiKi

Jessica Lucas

Erin

Laura Izibor

Derek Sommers

Ernest Waddell

Larry Sawyer

Kevin Kilner

Shelley Simon

Elisabeth Harnois

Cooper Lee

Michael Trucco

Ted Davis

Richard Burgi

Billy

Manu Intiraymi

Pablo Alvarez

David Norona

Jack Daniels

Evan Peters

Mrs. Skolnick

Kelley Davis

Sylvia Baker

Sharon Lawrence

August Kellerman

Peter Riegert

Larry Sawyer

Thomas Ian Griffith

Erica Marsh

Katherine Bailess

Tara Richards

Chelsea kane

Dr. Hale / Doctor

Dorothy Recasner Brown

Devon Fox / Ref

B.J. Britt

Reeves / Detective

David Bridgewater

Glenda

Amber Wallace

Alice

Kelly Collins Lintz

Young Keith

Patrick Stogner

Birth Mom / Bustier Woman / Waitress

Juliet Cesario

Ian Kellerman

Eric McIntire

Officer Stevens / Assistant

Stephen Elliott