Nathan Scott

James Lafferty

Brooke Davis

Sophia Bush

Haley James-Scott

Bethany Joy Galeotti

Marvin `Mouth' McFadden

Lee Norris

Julian Baker

Austin Nichols

Clay Evans

Robert Buckley

Dan Scott

Paul Johansson

Quinn James

Shantel VanSanten

Lucas Scott

Chad Michael Murray

Jamie Scott

Jackson Brundage

Peyton Sawyer

Hilarie Burton Morgan

Antwon 'Skills' Taylor

Antwon Tanner

Alex Dupré

Jana Kramer

Millicent `Millie' Huxtable

Lisa Goldstein

Chase Adams

Stephen Colletti

Chris Keller

Tyler Hilton

Guest Star

Barbara Alyn Woods

Whitey Durham

Barry Corbin

Pablo Alvarez

David Norona

Guest Star

Allison Munn

Tara Richards

Chelsea kane

Guest Star

Andrew Elvis Miller

Karen Roe

Moira Kelly

Guest Star

Sasha Jackson

Guest Star

Richard Burgi

Victoria Davis

Daphne Zuniga

Guest Star

Michael May

Xavier / Man

Devin McGee

Guest Star

Tom Nowicki

Guest Star

Pierce Gagnon

Keith Scott

Craig Sheffer

Rachel Gatina

Danneel Ackles

Fergie

Vaughn Wilson

Junk

Cullen Moss

Bevin

Bevin Prince

Mia Catalano

Kate Voegele

Tim Smith

Brett Claywell

Jake Jagielski

Bryan Greenberg

Jerry

Bradley Evans

Sam Walker

Ashley Rickards

Andy Hargrove

Kieren Hutchison

Gigi

Kelsey Asbille

Lindsey Strauss

Michaela McManus

Principal Turner

Shawn Shepard

Quentin Fields

Robbie Jones

Madison

Katherine Landry

Carrie

Torrey DeVitto

Owen Morello

Joe Manganiello

Felix Taggaro

Michael Copon

Anna Taggaro

Daniella Alonso

Paul Norris

Gregory Harrison

Miranda Stone

India de Beaufort

Katie / Sara

Amanda Schull

Jules

Maria Menounos

Nicki

Emmanuelle Vaugier

Grubbs

Michael Grubbs

Alexander Coyne

Mitch Ryan

Dr. Milford

Terry Loughlin

Ellie Harp

Sheryl Lee

Andre

Jaden Harmon

Taylor James

Lindsey McKeon

Bobby

Burgess Jenkins

Derek

Matt Barr

David Fletcher

Scott Holroyd

Renee

Kate French

Theresa

Sarah Edwards

Rick

William Haze

Dr. Hudson / KiKi

Jessica Lucas

Josh

Paul Teal

Erin

Laura Izibor

Derek Sommers

Ernest Waddell

Larry Sawyer

Kevin Kilner

Shelley Simon

Elisabeth Harnois

Cooper Lee

Michael Trucco

Billy

Manu Intiraymi

Jack Daniels

Evan Peters

Mrs. Skolnick

Kelley Davis

Sylvia Baker

Sharon Lawrence

August Kellerman

Peter Riegert

Larry Sawyer

Thomas Ian Griffith

Erica Marsh

Katherine Bailess

Lydia James

Bess Armstrong

Dr. Hale / Doctor

Dorothy Recasner Brown

Devon Fox / Ref

B.J. Britt

Reeves / Detective

David Bridgewater

Glenda

Amber Wallace

Alice

Kelly Collins Lintz

Young Keith

Patrick Stogner

Birth Mom / Bustier Woman / Waitress

Juliet Cesario

Ian Kellerman

Eric McIntire

Officer Stevens / Assistant

Stephen Elliott