Lucas Scott

Chad Michael Murray

Nathan Scott

James Lafferty

Peyton Sawyer

Hilarie Burton

Haley James Scott

Bethany Joy Lenz

Dan Scott

Paul Johansson

Brooke Davis

Sophia Bush

Coach Brian "Whitey" Durham

Barry Corbin

Marvin 'Mouth' McFadden

Lee Norris

Karen Roe

Moira Kelly

Keith Scott

Craig Sheffer

Deb Scott

Barbara Alyn Woods

Antwon 'Skills' Taylor

Antwon Tanner

Jamie Scott

Jackson Brundage

Guest Star

The Wreckers

Guest Star

Huey Lewis

Guest Star

Blake Bashoff

Guest Star

Micahel Copon

Millicent Huxtable

Lisa Goldstein

Guest Star

Emmanuelle Vaugier

Felix Taggaro

Michael Copon

Andy Hargrove

Kieren Hutchison

Erica Marsh

Katherine Bailess

Guest Star

Summer Altice

Anna Taggaro

Daniella Alonso

Guest Star

Stuart Lafferty

Lydia James

Bess Armstrong

Guest Star

Sheryl Lee

Guest Star

Michael Trucco

Jules

Maria Menounos

Chris Keller

Tyler Hilton

Guest Star

Brett Claywell

Guest Star

Matthew Lawrence

Guest Star

Vaughan Wilson

Guest Star

Spencer Cain

Taylor James

Lindsey McKeon

Guest Star

Nick Zano

Guest Star

Avis-Marie Barnes

Guest Star

Schuyler Fisk

Guest Star

Heather Shore

Guest Star

Ashley Novasad

Julian Baker

Austin Nichols

Guest Star

Sprague Grayden

Jake Jagielski

Bryan Greenberg

Guest Star

Cullen Moss

Clay Evans

Robert Buckley

Theresa

Sarah Edwards

Quinn James

Shantel VanSanten

Chase Adams

Stephen Colletti

Rachel Gatina

Danneel Ackles

Alex Dupre

Jana Kramer

Victoria Davis

Daphne Zuniga

Bevin

Bevin Prince

Mia Catalano

Kate Voegele

Chuck

Michael May

Lauren

Allison Munn

Jerry

Bradley Evans

Sam Walker

Ashley Rickards

Gigi

Kelsey Asbille

Lindsey Strauss

Michaela McManus

Principal Turner

Shawn Shepard

Quentin Fields

Robbie Jones

Madison

Katherine Landry

Carrie

Torrey DeVitto

Owen Morello

Joe Manganiello

Paul Norris

Gregory Harrison

Miranda Stone

India de Beaufort

Katie / Sara

Amanda Schull

Grubbs

Michael Grubbs

Alexander Coyne

Mitch Ryan

Dr. Milford

Terry Loughlin

Andre

Jaden Harmon

Bobby

Burgess Jenkins

Derek

Matt Barr

David Fletcher

Scott Holroyd

Renee

Kate French

Rick

William Haze

Xavier / Man

Devin McGee

Logan

Pierce Gagnon

Dr. Hudson / KiKi

Jessica Lucas

Josh

Paul Teal

Erin

Laura Izibor

Derek Sommers

Ernest Waddell

Larry Sawyer

Kevin Kilner

Shelley Simon

Elisabeth Harnois

Ted Davis

Richard Burgi

Billy

Manu Intiraymi

Pablo Alvarez

David Norona

Jack Daniels

Evan Peters

Mrs. Skolnick

Kelley Davis

Sylvia Baker

Sharon Lawrence

August Kellerman

Peter Riegert

Larry Sawyer

Thomas Ian Griffith

Tara Richards

Chelsea kane

Dr. Hale / Doctor

Dorothy Recasner Brown

Devon Fox / Ref

B.J. Britt

Reeves / Detective

David Bridgewater

Glenda

Amber Wallace

Alice

Kelly Collins Lintz

Kylie

Sasha Jackson

Young Keith

Patrick Stogner