Hank Hill / Boomhauer (voice)
Mike Judge
Peggy Hill
Kathy Najimy
Bobby Hill
Pamela S. Adlon
Dale Gribble
Johnny Hardwick
Luanne Platter (voice)
Brittany Murphy
Buck Strickland
Stephen Root
Nancy Hicks-Gribble / Didi Hill (voice)
Ashley Gardner
Dr. Leslie
Jason Bateman
Ms. Wakefield
Marion Ross
Guest Voice
Henry Winkler
Yuppie Woman #1
Maurissa Tancharoen
(voice) / Jimmy Witchard (voice) / Eustis Miller (voice)
David Herman
Lucky (voice) / Lucky / Mud Dobber (voice)
Tom Petty
Irv Bennett/Jimmy Beardon
Brendan Fraser
Enrique (voice) / Enrique / Octavio (voice)
Danny Trejo
(voice) / Joseph Gribble / Mr. Haggerty (voice)
Breckin Meyer
Lane Pratley (voice) / (voice) / Jimsey (voice)
Dave Thomas
Yolanda
Ruth Livier
(voice) / Burl Arlington / Harv Judd
Phil Hendrie
Minh Souphanousinphone/Kahn 'Connie' Souphanousinphone Jr.
Lauren Tom
Elvin Mackleston
Trace Adkins
Kahn Souphanousinphone / Cotton Hill (voice)
Toby Huss
Delivery Guy/Malik
Ajay Naidu
Carly/Felicia
Mo Collins
John Redcorn (voice) / John Redcorn / Driver #2 (voice)
Jonathan Joss
Sprinter
Timm Sharp
Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)
Joanna Gleason
Nureen
Stephanie Weir
Shelwyn
Glenn Morshower
Turpin
Neil Flynn
Principal Moss (voice) / Principal Moss / William B. Travis (voice)
Dennis Burkley
Smitty
Christopher Lloyd
(voice) / Mikey / Randy
Scott Klace
Head Coach/Sports Jock
Mac Davis
(voice) / Roger 'Booda' Sack (voice) / Ramsey (voice)
Phil LaMarr
(voice) / Nguc Phong (voice) / Doctor (voice)
James Sie
Tilly Hill (voice) / Nurse (voice) / (voice)
Beth Grant
(voice) / Kahn's Boss (voice) / Football Kid (voice)
Glenn L. Lucas
Chuck Mangione (voice)
Chuck Mangione
Customer (voice) / Redneck (voice) / (voice)
Randal Reeder
(voice) / Fire Chief / Reverend Thomason (voice)
Maurice LaMarche
Bob Jenkins (voice) / Bob Jenkins / Travis (voice)
Henry Gibson
Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)
Fred Willard
James (voice) / Eric (voice) / Kimmi (voice)
Tara Strong
Emily (voice) / (voice) / Emily
Ashley Johnson
Clerk (voice) / Mr. Holloway (voice) / Sergeant Barber (voice)
Billy West
Michiko (voice) / Mrs. Kalaiki-Alii (voice) / Mrs. Laoma Souphanousinphone (voice)
Amy Hill
Chris Sizemore (voice) / Ed Burnett (voice) / Rob Holguin (voice)
Chris Elliott
Kenny (voice) / Caleb (voice) / Arrow Kid #2
Paul Butcher
Randy Miller (voice) / (voice) / Velma Throckmorton (voice)
Cheryl Holliday
Enrique (voice) / (voice)
Eloy Casados
(voice) / Pops (voice) / C. Everett Koop (voice)
Jim Cummings
Jane (voice) / Waitress (voice) / Dawn (voice)
Rini Bell
(voice) / Guard (voice) / Cameraman
Wyatt Cenac