Hank Hill / Boomhauer (voice)

Mike Judge

Peggy Hill

Kathy Najimy

Bobby Hill

Pamela S. Adlon

Dale Gribble

Johnny Hardwick

Luanne Platter (voice)

Brittany Murphy

Buck Strickland

Stephen Root

Nancy Hicks-Gribble / Didi Hill (voice)

Ashley Gardner

Dr. Leslie

Jason Bateman

Ms. Wakefield

Marion Ross

Guest Voice

Henry Winkler

Yuppie Woman #1

Maurissa Tancharoen

(voice) / Jimmy Witchard (voice) / Eustis Miller (voice)

David Herman

Lucky (voice) / Lucky / Mud Dobber (voice)

Tom Petty

Irv Bennett/Jimmy Beardon

Brendan Fraser

Enrique (voice) / Enrique / Octavio (voice)

Danny Trejo

(voice) / Joseph Gribble / Mr. Haggerty (voice)

Breckin Meyer

Lane Pratley (voice) / (voice) / Jimsey (voice)

Dave Thomas

Yolanda

Ruth Livier

(voice) / Burl Arlington / Harv Judd

Phil Hendrie

Minh Souphanousinphone/Kahn 'Connie' Souphanousinphone Jr.

Lauren Tom

Elvin Mackleston

Trace Adkins

Kahn Souphanousinphone / Cotton Hill (voice)

Toby Huss

Delivery Guy/Malik

Ajay Naidu

Carly/Felicia

Mo Collins

John Redcorn (voice) / John Redcorn / Driver #2 (voice)

Jonathan Joss

Sprinter

Timm Sharp

Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)

Joanna Gleason

Nureen

Stephanie Weir

Shelwyn

Glenn Morshower

Turpin

Neil Flynn

Principal Moss (voice) / Principal Moss / William B. Travis (voice)

Dennis Burkley

Smitty

Christopher Lloyd

(voice) / Mikey / Randy

Scott Klace

Head Coach/Sports Jock

Mac Davis

(voice) / Roger 'Booda' Sack (voice) / Ramsey (voice)

Phil LaMarr

(voice) / Nguc Phong (voice) / Doctor (voice)

James Sie

Tilly Hill (voice) / Nurse (voice) / (voice)

Beth Grant

(voice) / Kahn's Boss (voice) / Football Kid (voice)

Glenn L. Lucas

Chuck Mangione (voice)

Chuck Mangione

Customer (voice) / Redneck (voice) / (voice)

Randal Reeder

(voice) / Fire Chief / Reverend Thomason (voice)

Maurice LaMarche

Bob Jenkins (voice) / Bob Jenkins / Travis (voice)

Henry Gibson

Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)

Fred Willard

James (voice) / Eric (voice) / Kimmi (voice)

Tara Strong

Emily (voice) / (voice) / Emily

Ashley Johnson

Clerk (voice) / Mr. Holloway (voice) / Sergeant Barber (voice)

Billy West

Michiko (voice) / Mrs. Kalaiki-Alii (voice) / Mrs. Laoma Souphanousinphone (voice)

Amy Hill

Chris Sizemore (voice) / Ed Burnett (voice) / Rob Holguin (voice)

Chris Elliott

Kenny (voice) / Caleb (voice) / Arrow Kid #2

Paul Butcher

Randy Miller (voice) / (voice) / Velma Throckmorton (voice)

Cheryl Holliday

Enrique (voice) / (voice)

Eloy Casados

(voice) / Pops (voice) / C. Everett Koop (voice)

Jim Cummings

Jane (voice) / Waitress (voice) / Dawn (voice)

Rini Bell

(voice) / Guard (voice) / Cameraman

Wyatt Cenac

Director

Shaun Cashman

Director

Klay Hall

Director

Allan Jacobsen

Director

Dominic Polcino

Director

Matt Engstrom