Hank Hill
Mike Judge
Peggy Hill
Kathy Najimy
Bobby Hill
Pamela S. Adlon
Dale Gribble
Johnny Hardwick
Buck Strickland
Stephen Root
Luanne Platter (voice)
Brittany Murphy
John Redcorn (voice) / John Redcorn / Driver #2 (voice)
Jonathan Joss
(voice) / Roger 'Booda' Sack (voice) / Ramsey (voice)
Phil LaMarr
Youth Group Member
Deryck Whibley
Ruth Brown/Sherilyn
Elizabeth Perkins
Patch Boomhauer
Brad Pitt
(voice) / Burl Arlington / Harv Judd
Phil Hendrie
Guest Voice
John Force
Yogi Victor
Johnny Depp
Colette/Attorney
Christina Applegate
Topaz/Singing Hippie
Melissa Etheridge
Kahn Souphanousinphone / Cotton Hill (voice)
Toby Huss
Stacey Gibson
Alyson Hannigan
Artist/Voice on the Phone
Nicky Katt
Enrique (voice) / Enrique / Octavio (voice)
Danny Trejo
Sports Jock/Announcer
Mac Davis
April
Laura Prepon
Jeremy
Tony Denman
Trent - Youth Group Member
Dave Baksh
Doctor Tabor
Larry Miller
Minh Souphanousinphone / Connie Souphanousinphone (voice)
Lauren Tom
Katherine
Laura Dern
(voice) / Jimmy Witchard (voice) / Eustis Miller (voice)
David Herman
Jo Rita
Peri Gilpin
Lucky (voice) / Lucky / Mud Dobber (voice)
Tom Petty
Fudgie/Police Chief
Jamie Kennedy
Mrs. Hanover/Pretty Student
Marg Helgenberger
Lane Pratley (voice) / (voice) / Jimsey (voice)
Dave Thomas
Chip
Brad Paisley
Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)
Fred Willard
Nancy Hicks-Gribble / Didi Hill (voice)
Ashley Gardner
Youth Group Member
Cone McCaslin
Elvin Mackleston
Trace Adkins
Rich
Ben Stiller
Customer
Pat Fraley
Stoned Hippie Chick/Teen Girl Hippie
Anna Faris
Cornell
George Strait
Youth Group Member
Steve Jocz
Chris Sizemore (voice) / Ed Burnett (voice) / Rob Holguin (voice)
Chris Elliott
Emily (voice) / (voice) / Emily
Ashley Johnson
Jason
Elijah Wood
Jessie
Gene Simmons
Social Director
Katherine Crabtree
Sally
Deana Carter
(voice) / Joseph Gribble / Mr. Haggerty (voice)
Breckin Meyer
Appleseed
Dave Allen
Merilynn/Sunshine
Amy Adams
Zack
Dax Shepard
Walt
Travis Tritt
Misty
Danica McKellar
Melly-Anne
Mary Kay Place
Principal Moss (voice) / Principal Moss / William B. Travis (voice)
Dennis Burkley
(voice) / Mikey / Randy
Scott Klace
Dawn
Kelly Clarkson
Speck
Norwood Cheek
Quizmaster
Ben Stein
Guest Voice
David Denman
Eugene Grandy
John Ritter
(voice) / Nguc Phong (voice) / Doctor (voice)
James Sie
Tilly Hill (voice) / Nurse (voice) / (voice)
Beth Grant
(voice) / Kahn's Boss (voice) / Football Kid (voice)
Glenn L. Lucas
Chuck Mangione (voice)
Chuck Mangione
Customer (voice) / Redneck (voice) / (voice)
Randal Reeder
Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)
Joanna Gleason
(voice) / Fire Chief / Reverend Thomason (voice)
Maurice LaMarche
Bob Jenkins (voice) / Bob Jenkins / Travis (voice)
Henry Gibson
James (voice) / Eric (voice) / Kimmi (voice)
Tara Strong
Clerk (voice) / Mr. Holloway (voice) / Sergeant Barber (voice)
Billy West
Michiko (voice) / Mrs. Kalaiki-Alii (voice) / Mrs. Laoma Souphanousinphone (voice)
Amy Hill
Kenny (voice) / Caleb (voice) / Arrow Kid #2
Paul Butcher
Randy Miller (voice) / (voice) / Velma Throckmorton (voice)
Cheryl Holliday
Enrique (voice) / (voice)
Eloy Casados
(voice) / Pops (voice) / C. Everett Koop (voice)
Jim Cummings
Jane (voice) / Waitress (voice) / Dawn (voice)
Rini Bell
(voice) / Guard (voice) / Cameraman
Wyatt Cenac