Hank Hill / Boomhauer (voice)

Mike Judge

Peggy Hill (voice)

Kathy Najimy

Bobby Hill

Pamela S. Adlon

Dale Gribble (voice)

Johnny Hardwick

Buck Strickland

Stephen Root

Luanne Platter (voice)

Brittany Murphy

John Redcorn (voice) / John Redcorn / Driver #2 (voice)

Jonathan Joss

Minh Souphanousinphone / Connie Souphanousinphone (voice)

Lauren Tom

(voice) / Roger 'Booda' Sack (voice) / Vietnam War Veteran (voice)

Phil LaMarr

Youth Group Member

Deryck Whibley

Ruth Brown/Sherilyn

Elizabeth Perkins

Patch Boomhauer

Brad Pitt

(voice) / Burl Arlington / Harv Judd

Phil Hendrie

Guest Voice

John Force

Yogi Victor

Johnny Depp

Colette/Attorney

Christina Applegate

Topaz/Singing Hippie

Melissa Etheridge

Dale Gribble / Cotton Hill / Kahn Souphanousinphone (voice)

Toby Huss

Stacey Gibson

Alyson Hannigan

Artist/Voice on the Phone

Nicky Katt

Enrique (voice) / (voice) / Lifeguard

Danny Trejo

Sports Jock/Announcer

Mac Davis

April

Laura Prepon

Jeremy

Tony Denman

Trent - Youth Group Member

Dave Baksh

Doctor Tabor

Larry Miller

Katherine

Laura Dern

(voice) / Buckley (voice) / Jimmy Witchard (voice)

David Herman

Jo Rita

Peri Gilpin

Lucky (voice) / Lucky / Mud Dobber (voice)

Tom Petty

Fudgie/Police Chief

Jamie Kennedy

Mrs. Hanover/Pretty Student

Marg Helgenberger

Lane Pratley (voice) / (voice) / Toothless Loser (voice)

Dave Thomas

Chip

Brad Paisley

Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)

Fred Willard

Nancy Hicks Gribble/Didi Hill

Ashley Gardner

Youth Group Member

Cone McCaslin

Elvin Mackleston

Trace Adkins

Rich

Ben Stiller

Customer

Pat Fraley

Stoned Hippie Chick/Teen Girl Hippie

Anna Faris

Cornell

George Strait

Youth Group Member

Steve Jocz

Chris Sizemore (voice) / Rob Holguin (voice) / Ed Burnett (voice)

Chris Elliott

Emily (voice) / (voice) / Emily

Ashley Johnson

Jason

Elijah Wood

Jessie

Gene Simmons

Social Director

Katherine Crabtree

Sally

Deana Carter

Joseph Gribble (voice) / (voice) / Joseph Gribble

Breckin Meyer

Appleseed

Dave Allen

Merilynn/Sunshine

Amy Adams

Zack

Dax Shepard

Walt

Travis Tritt

Misty

Danica McKellar

Melly-Anne

Mary Kay Place

Dawn

Kelly Clarkson

Principal Moss (voice) / (voice) / Principal Moss

Dennis Burkley

(voice) / Mikey / Randy

Scott Klace

Speck

Norwood Cheek

Quizmaster

Ben Stein

Guest Voice

David Denman

Eugene Grandy

John Ritter

(voice) / Nguc Phong (voice) / Doctor (voice)

James Sie

Kahn Souphanousinphone

Ronny Chieng

Nurse (voice) / Tilly Hill (voice) / (voice)

Beth Grant

(voice) / Kahn's Boss (voice) / Football Kid (voice)

Glenn L. Lucas

Chuck Mangione (voice)

Chuck Mangione

Customer (voice) / Rollo / Coach (voice)

Randal Reeder

Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)

Joanna Gleason

(voice) / Professor John Lerner (voice) / Fire Chief

Maurice LaMarche

Bob Jenkins (voice) / Bob Jenkins / Travis (voice)

Henry Gibson

Eric (voice) / Billy (voice) / James (voice)

Tara Strong

Mr. Holloway (voice) / Clerk (voice) / Sergeant Barber (voice)

Billy West

Mrs. Kalaiki-Alii (voice) / Michiko (voice) / Mrs. Laoma Souphanousinphone (voice)

Amy Hill

Kenny (voice) / Caleb (voice) / Arrow Kid #2

Paul Butcher

Randy Miller (voice) / (voice) / Velma Throckmorton (voice)

Cheryl Holliday

Enrique (voice) / (voice)

Eloy Casados

Pops (voice) / Bounty Hunter / Jimmy Helstrom (voice)

Jim Cummings

Jane (voice) / Olivia (voice) / Dawn (voice)

Rini Bell

(voice) / Cameraman / Dr. Stephens (voice)

Wyatt Cenac