Hank Hill

Mike Judge

Peggy Hill

Kathy Najimy

Bobby Hill

Pamela S. Adlon

Dale Gribble

Johnny Hardwick

Buck Strickland

Stephen Root

Luanne Platter (voice)

Brittany Murphy

John Redcorn (voice) / John Redcorn / Driver #2 (voice)

Jonathan Joss

(voice) / Roger 'Booda' Sack (voice) / Ramsey (voice)

Phil LaMarr

Youth Group Member

Deryck Whibley

Ruth Brown/Sherilyn

Elizabeth Perkins

Patch Boomhauer

Brad Pitt

(voice) / Burl Arlington / Harv Judd

Phil Hendrie

Guest Voice

John Force

Yogi Victor

Johnny Depp

Colette/Attorney

Christina Applegate

Topaz/Singing Hippie

Melissa Etheridge

Kahn Souphanousinphone / Cotton Hill (voice)

Toby Huss

Stacey Gibson

Alyson Hannigan

Artist/Voice on the Phone

Nicky Katt

Enrique (voice) / Enrique / Octavio (voice)

Danny Trejo

Sports Jock/Announcer

Mac Davis

April

Laura Prepon

Jeremy

Tony Denman

Trent - Youth Group Member

Dave Baksh

Doctor Tabor

Larry Miller

Minh Souphanousinphone / Connie Souphanousinphone (voice)

Lauren Tom

Katherine

Laura Dern

(voice) / Jimmy Witchard (voice) / Eustis Miller (voice)

David Herman

Jo Rita

Peri Gilpin

Lucky (voice) / Lucky / Mud Dobber (voice)

Tom Petty

Fudgie/Police Chief

Jamie Kennedy

Mrs. Hanover/Pretty Student

Marg Helgenberger

Lane Pratley (voice) / (voice) / Jimsey (voice)

Dave Thomas

Chip

Brad Paisley

Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)

Fred Willard

Nancy Hicks-Gribble / Didi Hill (voice)

Ashley Gardner

Youth Group Member

Cone McCaslin

Elvin Mackleston

Trace Adkins

Rich

Ben Stiller

Customer

Pat Fraley

Stoned Hippie Chick/Teen Girl Hippie

Anna Faris

Cornell

George Strait

Youth Group Member

Steve Jocz

Chris Sizemore (voice) / Ed Burnett (voice) / Rob Holguin (voice)

Chris Elliott

Emily (voice) / (voice) / Emily

Ashley Johnson

Jason

Elijah Wood

Jessie

Gene Simmons

Social Director

Katherine Crabtree

Sally

Deana Carter

(voice) / Joseph Gribble / Mr. Haggerty (voice)

Breckin Meyer

Appleseed

Dave Allen

Merilynn/Sunshine

Amy Adams

Zack

Dax Shepard

Walt

Travis Tritt

Misty

Danica McKellar

Melly-Anne

Mary Kay Place

Principal Moss (voice) / Principal Moss / William B. Travis (voice)

Dennis Burkley

(voice) / Mikey / Randy

Scott Klace

Dawn

Kelly Clarkson

Speck

Norwood Cheek

Quizmaster

Ben Stein

Guest Voice

David Denman

Eugene Grandy

John Ritter

(voice) / Nguc Phong (voice) / Doctor (voice)

James Sie

Tilly Hill (voice) / Nurse (voice) / (voice)

Beth Grant

(voice) / Kahn's Boss (voice) / Football Kid (voice)

Glenn L. Lucas

Chuck Mangione (voice)

Chuck Mangione

Customer (voice) / Redneck (voice) / (voice)

Randal Reeder

Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)

Joanna Gleason

(voice) / Fire Chief / Reverend Thomason (voice)

Maurice LaMarche

Bob Jenkins (voice) / Bob Jenkins / Travis (voice)

Henry Gibson

James (voice) / Eric (voice) / Kimmi (voice)

Tara Strong

Clerk (voice) / Mr. Holloway (voice) / Sergeant Barber (voice)

Billy West

Michiko (voice) / Mrs. Kalaiki-Alii (voice) / Mrs. Laoma Souphanousinphone (voice)

Amy Hill

Kenny (voice) / Caleb (voice) / Arrow Kid #2

Paul Butcher

Randy Miller (voice) / (voice) / Velma Throckmorton (voice)

Cheryl Holliday

Enrique (voice) / (voice)

Eloy Casados

(voice) / Pops (voice) / C. Everett Koop (voice)

Jim Cummings

Jane (voice) / Waitress (voice) / Dawn (voice)

Rini Bell

(voice) / Guard (voice) / Cameraman

Wyatt Cenac

Director

Shaun Cashman

Director

Klay Hall

Director

Allan Jacobsen

Director

Dominic Polcino

Director

Matt Engstrom