Hank Hill
Mike Judge
Peggy Hill
Kathy Najimy
Bobby Hill
Pamela Segal
Dale Gribble (voice)
Johnny Hardwick
Luanne Platter
Brittany Murphy
Bill Dauterive / Buck Strickland (voice)
Stephen Root
Nancy Hicks-Gribble / Didi Hill (voice)
Ashley Gardner
Kahn Souphanousinphone / Cotton Hill (voice)
Toby Huss
Patrol Officer Jane Cooper
Kathy Bates
John Redcorn (voice) / John Redcorn / Driver #2 (voice)
Jonathan Joss
King Philip
Alan Rickman
Minh Souphanousinphone / Connie Souphanousinphone (voice)
Lauren Tom
(voice) / Jimmy Witchard (voice) / Eustis Miller (voice)
David Herman
Marlene
Laura Linney
Anne
Lupe Ontiveros
(voice) / Joseph Gribble / Mr. Haggerty (voice)
Breckin Meyer
Principal Moss (voice) / Principal Moss / William B. Travis (voice)
Dennis Burkley
Guest Voice
Yakov Smirnoff
Mr. Ho
Peter Kwong
Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)
Fred Willard
Lisa
Anna Faris
Serving Wench
Laura Dern
Stinky
Edward Asner
Mother Superior/Mrs. Bonter
Kathryn Harrold
Sister Mary Catherine/Claire
Cynthia Stevenson
James (voice) / Eric (voice) / Kimmi (voice)
Tara Strong
Betty
Patricia Place
Lupe
Marisabel Garcia
Charisse
Eliza Schneider
Guest Voice
Charlie Daniels
(voice) / Roger 'Booda' Sack (voice) / Ramsey (voice)
Phil LaMarr
Irwin Linker
Jack Carter
Mexican Police Officer/Mr. Ortiz
Carlos Alazraqui
Guest Voice
Marcelo Tubert
Oxcart-Driving Minstrel
Andy Siegel
Jane #2
Stephanie Fybel
Susan Clemmons
Madeline Zima
Dr. Vayzosa
Jeff Goldblum
Boomhauer's Singing Voice
Vince Gill
One-Armed Ronnie/Ranger
John C. McGinley
Guest Voice
Castulo Guerra
(voice) / Mikey / Randy
Scott Klace
Lucky (voice) / Lucky / Mud Dobber (voice)
Tom Petty
(voice) / Burl Arlington / Harv Judd
Phil Hendrie
Enrique (voice) / Enrique / Octavio (voice)
Danny Trejo
Lane Pratley (voice) / (voice) / Jimsey (voice)
Dave Thomas
(voice) / Nguc Phong (voice) / Doctor (voice)
James Sie
Tilly Hill (voice) / Nurse (voice) / (voice)
Beth Grant
(voice) / Kahn's Boss (voice) / Football Kid (voice)
Glenn L. Lucas
Chuck Mangione (voice)
Chuck Mangione
Customer (voice) / Redneck (voice) / (voice)
Randal Reeder
Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)
Joanna Gleason
(voice) / Fire Chief / Reverend Thomason (voice)
Maurice LaMarche
Bob Jenkins (voice) / Bob Jenkins / Travis (voice)
Henry Gibson
Emily (voice) / (voice) / Emily
Ashley Johnson
Clerk (voice) / Mr. Holloway (voice) / Sergeant Barber (voice)
Billy West
Michiko (voice) / Mrs. Kalaiki-Alii (voice) / Mrs. Laoma Souphanousinphone (voice)
Amy Hill
Chris Sizemore (voice) / Ed Burnett (voice) / Rob Holguin (voice)
Chris Elliott
Kenny (voice) / Caleb (voice) / Arrow Kid #2
Paul Butcher
Randy Miller (voice) / (voice) / Velma Throckmorton (voice)
Cheryl Holliday
Enrique (voice) / (voice)
Eloy Casados
(voice) / Pops (voice) / C. Everett Koop (voice)
Jim Cummings
Jane (voice) / Waitress (voice) / Dawn (voice)
Rini Bell
(voice) / Guard (voice) / Cameraman
Wyatt Cenac