Hank Hill
Mike Judge
Peggy Hill
Kathy Najimy
Bobby Hill
Pamela Segall
Luanne Platter
Brittany Murphy
Dale Gribble
Johnny Hardwick
Gary Kasner
Carl Reiner
Roger 'Booda' Sack
Chris Rock
Jacinto
Paul Rodriguez
Guest Voice
Troy Aikman
Guest Voice
Dale Earnhardt
Guest Voice
Green Day
Judge
James Carville
Junie Harper
Sally Field
Bill Dauterive / Buck Strickland (voice)
Stephen Root
Emily
Ani DiFranco
Guest Voice
Kerri Strug
M.F. Thatherton
Burt Reynolds
Amy
Jennifer Jason Leigh
Receptionist
Patricia Childress
Tilly Hill
Tammy Wynette
John Redcorn (voice) / John Redcorn / Driver #2 (voice)
Jonathan Joss
Angela
Angela Kinsey
Closer #2
Neil Guintoli
Glen Johnson
John Amos
Eugene Grandy
John Ritter
Wheezie
Neal Giuntoli
(voice) / Jimmy Witchard (voice) / Eustis Miller (voice)
David Herman
Kahn Souphanousinphone / Cotton Hill (voice)
Toby Huss
Mrs. Holloway
Stockard Channing
Miss Kremzer
Jennifer Coolidge
Salesman
Steve Vinovich
Billy
Tara Charendoff
(voice) / Fire Chief / Reverend Thomason (voice)
Maurice LaMarche
Maddy Platter (voice) / Marie's Mother (voice) / Nurse (voice)
Joanna Gleason
Judge
Lynne Thigpen
Rifle Shooting Instructor
Wallace Shawn
Pops
Jim Cummings
Michiko (voice) / Mrs. Kalaiki-Alii (voice) / Mrs. Laoma Souphanousinphone (voice)
Amy Hill
Principal Moss (voice) / Principal Moss / William B. Travis (voice)
Dennis Burkley
Attorney
Dan Butler
Chuck Mangione (voice)
Chuck Mangione
Magistrate
Castulo Guerra
Tilly Hill (voice) / Nurse (voice) / (voice)
Beth Grant
Clerk (voice) / Mr. Holloway (voice) / Sergeant Barber (voice)
Billy West
National Anthem Singer
Peabo Bryson
Dealer
Brent Forrester
Minh Souphanousinphone / Connie Souphanousinphone (voice)
Lauren Tom
Kidd Mookie
Orlando Jones
Enrique (voice) / (voice)
Eloy Casados
Nancy Hicks-Gribble / Didi Hill (voice)
Ashley Gardner
Randy Miller (voice) / (voice) / Velma Throckmorton (voice)
Cheryl Holliday
Group Leader
David Zuckerman
Kid
Debi Derryberry
Mexican Woman
Bertila Damas
Jason Adderly
Jim Dauterive
Student
Mark Humphrey
(voice) / Mikey / Randy
Scott Klace
Lucky (voice) / Lucky / Mud Dobber (voice)
Tom Petty
(voice) / Burl Arlington / Harv Judd
Phil Hendrie
(voice) / Roger 'Booda' Sack (voice) / Ramsey (voice)
Phil LaMarr
Enrique (voice) / Enrique / Octavio (voice)
Danny Trejo
Lane Pratley (voice) / (voice) / Jimsey (voice)
Dave Thomas
(voice) / Nguc Phong (voice) / Doctor (voice)
James Sie
(voice) / Kahn's Boss (voice) / Football Kid (voice)
Glenn L. Lucas
Customer (voice) / Redneck (voice) / (voice)
Randal Reeder
Bob Jenkins (voice) / Bob Jenkins / Travis (voice)
Henry Gibson
Officer Brown (voice) / Ranger Bradley / Reclining Hippie (voice)
Fred Willard
Emily (voice) / (voice) / Emily
Ashley Johnson
Chris Sizemore (voice) / Ed Burnett (voice) / Rob Holguin (voice)
Chris Elliott
(voice) / Joseph Gribble / Mr. Haggerty (voice)
Breckin Meyer
Kenny (voice) / Caleb (voice) / Arrow Kid #2
Paul Butcher
(voice) / Pops (voice) / C. Everett Koop (voice)
Jim Cummings
Jane (voice) / Waitress (voice) / Dawn (voice)
Rini Bell
(voice) / Guard (voice) / Cameraman
Wyatt Cenac