Penny
Kaley Cuoco
Leonard Hofstadter
Johnny Galecki
Sheldon Cooper
Jim Parsons
Howard Wolowitz
Simon Helberg
Raj Koothrappali
Kunal Nayyar
Amy Farrah Fowler
Mayim Bialik
Bernadette Rostenkowski
Melissa Rauch
Employee
Efrain Gomez
Doctor Wolcott
Peter MacNicol
Kripke
John Ross Bowie
Stuart Bloom
Kevin Sussman
Georgie
Jerry O'Connell
Mary
Laurie Metcalf
Janine Davis
Regina King
Nell
Beth Behrs
Arthur Jeffries
Bob Newhart
Oliver
Walter Goggins
President Siebert
Joshua Malina
Bert Kibbler
Brian Posehn
Colonel Williams
Dean Norris
Dr. Koothrappali
Brian George
Mrs. Petrescu
Michelle Arthur
Self
Ira Flatow
Himself
Neil Gaiman
Margaret
Lynn Andrews
Halley Wolowitz (voice)
Pamela Adlon
Bartender
James Maslow
Zack Johnson
Brian Thomas Smith
Himself
Bill Gates
Ruchi
Swati Kapila
Beverly Hofstadter
Christine Baranski
Dr. Samuel
Dana L. Wilson
Kathleen
Rachna Khatau
Pit Boss
Mark Berry
Debbie Wolowitz (voice)
Carol Ann Susi
Mailman
Edward James Gage
Police Officer
Michael Patrick McGill
Ramona
Riki Lindhome
Marcus
Parvesh Cheena
Danielle
Marissa Cuevas
Denise
Lauren Lapkus
Jenna
Ellie Reed
Wil Wheaton
Wil Wheaton
Jess
Caleb Pierce
Stephen Hawking
Stephen Hawking
Wendell
Bob Stephenson
Denise
Brooke Baumer
Grant
Patrick Daniel
Croupier
Evan Charest
Rose Lady
Elka Rodriguez
Cynthia
Megan McGown
Hostess
D'Kia Anderson
Dr. Zhang
George Wyner
Clerk
Nicole Butler
Dr. Harris
Susan Chuang
Earl
Seth Coltan
Missy
Courtney Henggeler
Mr. Fowler
Teller
Mrs. Fowler
Kathy Bates
Anu
Rati Gupta
Himself
Mark Hamill
Althea
Vernee Watson-Johnson
Mike Rostenkowski
Casey Sander
Michael J. Massimino
Michael J. Massimino
Claire
Alessandra Torresani
Eric Gablehauser
Mark Harelik
Announcer (voice) / Man / Man V.O. (voice)
Ed Lieberman
Wyatt Teller
Keith Carradine
Dimitri
Pasha D. Lychnikoff
Aarti Mann