Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Guest Star

Brendan Fletcher

Guest Star

Megalyn Echikunwoke

Guest Star

Julie Benz

Meg Masters

Nicki Aycox

Guest Star

Marnette Patterson

Guest Star

Ryan Drescher

John Winchester

Jeffrey Dean Morgan

Guest Star

Loretta Devine

Castiel / Jimmy Novak / Emmanuel

Misha Collins

Jessica Moore

Adrianne Palicki

Guest Star

Terence Kelly

Mary Winchester

Samantha Smith

Crowley

Mark Sheppard

Bobby Singer

Jim Beaver

Ross Kohn

Rowena MacLeod

Ruth Connell

Jack / Belphegor

Alexander Calvert

Lucifer

Mark Pellegrino

Arthur Ketch

David Haydn-Jones

Jody Mills

Kim Rhodes

Amara / Amara (Adult) / Karin

Emily Swallow

Ruby / Genevieve Padalecki

Genevieve Padalecki

Metatron

Curtis Armstrong

Gabriel / Trickster

Richard Speight Jr.

Charlie Bradbury

Felicia Day

Lisa Braeden

Cindy Sampson

Billie

Lisa Berry

Eli / Benny Lafitte

Ty Olsson

Naomi

Amanda Tapping

Kelly Kline

Courtney Ford

Donatello Redfield / God

Keith Szarabajka

Adam Milligan / Michael

Jake Abel

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Duma / The Shadow / Robin

Erica Cerra

Kevin Tran

Osric Chau

Samuel Campbell / Shapeshifter

Mitch Pileggi

Zachariah

Kurt Fuller

Ellen Harvelle

Samantha Ferris

Meg Masters

Rachel Miner

Abaddon

Alaina Huffman

Eileen Leahy

Shoshannah Stern

Jo Harvelle

Alona Tal

Maggie

Katherine Evans

Liane Balaban

Donna Hanscum

Briana Buckmaster

Balthazar

Sebastian Roché

Claire Novak

Kathryn Newton

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Garth Fitzgerald / Garth Fitzgerald

DJ Qualls

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

God

Rob Benedict

Death

Julian Richings

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Gadreel / Ezekiel

Tahmoh Penikett

Mick Davies

Adam Fergus

Pamela Barnes

Traci Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Alex Jones

Katherine Ramdeen

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg