Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Guest Star

Kim Rhodes

Castiel / Jimmy Novak / Emmanuel

Misha Collins

Charlie Bradbury

Felicia Day

Guest Star

Danielle Savre

Gadreel / Ezekiel

Tahmoh Penikett

Guest Star

D.J. Qualls

Guest Star

Alaina Huffman

Guest Star

Nicole "Snooki" Polizzi

Guest Star

Ali Webb

Guest Star

Jenny O'Hara

Guest Star

Blake Gibbons

Guest Star

Mark Sheppard

Guest Star

Tim Omundson

Guest Star

Adam Harrington

Guest Star

Gil McKinney

Guest Star

Erin Karpluk

Guest Star

Maria Marlow

Guest Star

Tiio Horn

Guest Star

Osric Chau

Guest Star

Nathaniel Buzolic

Guest Star

Curtis Armstrong

Guest Star

Gordon Woolvet

Guest Star

Katherine Ramdeen

Guest Star

Sean Faris

Guest Star

Rebecca Marshall

Guest Star

Maya Massar

Guest Star

Ryan Moss

Guest Star

Kavan Smith

Guest Star

A.J. Buckley

Bobby Singer

Jim Beaver

Guest Star

Lucien Laviscount

Rowena MacLeod

Ruth Connell

Jack / Belphegor

Alexander Calvert

Mary Winchester

Samantha Smith

Lucifer

Mark Pellegrino

Arthur Ketch

David Haydn-Jones

Amara / Amara (Adult) / Karin

Emily Swallow

Ruby / Genevieve Padalecki

Genevieve Padalecki

Gabriel / Trickster

Richard Speight Jr.

John Winchester

Jeffrey Dean Morgan

Lisa Braeden

Cindy Sampson

Billie

Lisa Berry

Eli / Benny Lafitte

Ty Olsson

Naomi

Amanda Tapping

Kelly Kline

Courtney Ford

Donatello Redfield / God

Keith Szarabajka

Adam Milligan / Michael

Jake Abel

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Duma / The Shadow / Robin

Erica Cerra

Samuel Campbell / Shapeshifter

Mitch Pileggi

Zachariah

Kurt Fuller

Ellen Harvelle

Samantha Ferris

Meg Masters

Rachel Miner

Eileen Leahy

Shoshannah Stern

Maggie

Katherine Evans

Jo Harvelle

Alona Tal

Donna Hanscum

Briana Buckmaster

Liane Balaban

Balthazar

Sebastian Roché

Claire Novak

Kathryn Newton

Young Sam Winchester

Colin Ford

Rufus Turner

Steven Williams

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

God

Rob Benedict

Jessica Moore

Adrianne Palicki

Death

Julian Richings

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Meg Masters

Nicki Aycox

Mick Davies

Adam Fergus

Pamela Barnes

Traci Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg