Sam Winchester

Jared Padalecki

Dean Winchester

Jensen Ackles

Castiel / Emmanuel / Jimmy Novak

Misha Collins

Crowley

Mark Sheppard

Bobby Singer

Jim Beaver

Guest Star

Mark Pellegrino

Dee Wallace

Guest Star

Kim Rhodes

Guest Star

Nate Torrence

Amara / Amara (Adult) / Karin

Emily Swallow

Guest Star

Mike "The Miz" Mizanin

Guest Star

Jared Gertner

Guest Star

Curtis Armstrong

Rowena MacLeod

Ruth Connell

Guest Star

Rob Benedict

Guest Star

Aleks Paunovic

John Winchester

Jeffrey Dean Morgan

Claire Novak

Kathryn Newton

Guest Star

Yasmeene Ball

Rufus Turner

Steven Williams

Guest Star

Katherine Ramdeen

Jack / Belphegor

Alexander Calvert

Mary Winchester

Samantha Smith

Kevin Tran

Osric Chau

Ellen Harvelle

Samantha Ferris

Arthur Ketch

David Haydn-Jones

Samuel Campbell / Shapeshifter

Mitch Pileggi

Eli / Benny Lafitte

Ty Olsson

Jo Harvelle

Alona Tal

Ruby / Genevieve Padalecki

Genevieve Padalecki

Zachariah

Kurt Fuller

Gabriel / Trickster

Richard Speight Jr.

Liane Balaban

Charlie Bradbury

Felicia Day

Lisa Braeden

Cindy Sampson

Billie

Lisa Berry

Naomi

Amanda Tapping

Kelly Kline

Courtney Ford

Donatello Redfield / God

Keith Szarabajka

Adam Milligan / Michael

Jake Abel

Hannah / Caroline Johnson / Young Mother

Erica Carroll

Duma / The Shadow / Robin

Erica Cerra

Meg Masters

Rachel Miner

Abaddon

Alaina Huffman

Eileen Leahy

Shoshannah Stern

Maggie

Katherine Evans

Donna Hanscum

Briana Buckmaster

Balthazar

Sebastian Roché

Young Sam Winchester

Colin Ford

Garth Fitzgerald / Garth Fitzgerald

DJ Qualls

Toni Bevell

Elizabeth Blackmore

Anna Milton

Julie McNiven

Bela Talbot

Lauren Cohan

Ruby

Katie Cassidy

Jessica Moore

Adrianne Palicki

Death

Julian Richings

Edgar

Benito Martinez

Ben Braeden

Nicholas Elia

Gadreel / Ezekiel

Tahmoh Penikett

Meg Masters

Nicki Aycox

Mick Davies

Adam Fergus

Pamela Barnes

Thunderbird Dinwiddie

Sister Jo / Anael

Danneel Ackles

Uriel

Robert Wisdom

Michael

Christian Keyes

Asmodeus

Jeffrey Vincent Parise

Kaia Nieves / Dark Kaia

Yadira Guevara-Prip

Ash

Chad Lindberg